Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment
Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapenta...
Published in: | International Journal of Molecular Sciences |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2017
|
Subjects: | |
Online Access: | https://doi.org/10.3390/ijms18122554 https://doaj.org/article/21a95dd729b64abb9050d40e3004dbda |
id |
ftdoajarticles:oai:doaj.org/article:21a95dd729b64abb9050d40e3004dbda |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:21a95dd729b64abb9050d40e3004dbda 2023-05-15T13:52:41+02:00 Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment Ji Yeon Choi Jun Sung Jang Dong Ju Son Hyung-Sik Im Ji Yeong Kim Joung Eun Park Won Rak Choi Sang-Bae Han Jin Tae Hong 2017-11-01T00:00:00Z https://doi.org/10.3390/ijms18122554 https://doaj.org/article/21a95dd729b64abb9050d40e3004dbda EN eng MDPI AG https://www.mdpi.com/1422-0067/18/12/2554 https://doaj.org/toc/1422-0067 1422-0067 doi:10.3390/ijms18122554 https://doaj.org/article/21a95dd729b64abb9050d40e3004dbda International Journal of Molecular Sciences, Vol 18, Iss 12, p 2554 (2017) neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil Biology (General) QH301-705.5 Chemistry QD1-999 article 2017 ftdoajarticles https://doi.org/10.3390/ijms18122554 2022-12-31T07:44:11Z Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss. We also found that krill oil treatment inhibited the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and decreased reactive oxygen species (ROS) and malondialdehyde levels. Krill oil also suppresses IκB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. In association with the inhibitory effect on neuroinflammation and oxidative stress, krill oil suppressed amyloid beta (1–42) peptide generation by the down-regulating APP and BACE1 expression in vivo. We found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (50 and 100 µM) dose-dependently decreased LPS-induced nitric oxide and ROS generation, and COX-2 and iNOS expression as well as nuclear factor-κB activity in cultured microglial BV-2 cells. These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Euphausia superba Directory of Open Access Journals: DOAJ Articles Antarctic International Journal of Molecular Sciences 18 12 2554 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil Biology (General) QH301-705.5 Chemistry QD1-999 |
spellingShingle |
neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil Biology (General) QH301-705.5 Chemistry QD1-999 Ji Yeon Choi Jun Sung Jang Dong Ju Son Hyung-Sik Im Ji Yeong Kim Joung Eun Park Won Rak Choi Sang-Bae Han Jin Tae Hong Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
topic_facet |
neuroinflammation amyloidogenesis oxidation nuclear factor-κB krill oil Biology (General) QH301-705.5 Chemistry QD1-999 |
description |
Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss. We also found that krill oil treatment inhibited the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and decreased reactive oxygen species (ROS) and malondialdehyde levels. Krill oil also suppresses IκB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. In association with the inhibitory effect on neuroinflammation and oxidative stress, krill oil suppressed amyloid beta (1–42) peptide generation by the down-regulating APP and BACE1 expression in vivo. We found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (50 and 100 µM) dose-dependently decreased LPS-induced nitric oxide and ROS generation, and COX-2 and iNOS expression as well as nuclear factor-κB activity in cultured microglial BV-2 cells. These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms. |
format |
Article in Journal/Newspaper |
author |
Ji Yeon Choi Jun Sung Jang Dong Ju Son Hyung-Sik Im Ji Yeong Kim Joung Eun Park Won Rak Choi Sang-Bae Han Jin Tae Hong |
author_facet |
Ji Yeon Choi Jun Sung Jang Dong Ju Son Hyung-Sik Im Ji Yeong Kim Joung Eun Park Won Rak Choi Sang-Bae Han Jin Tae Hong |
author_sort |
Ji Yeon Choi |
title |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_short |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_full |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_fullStr |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_full_unstemmed |
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment |
title_sort |
antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment |
publisher |
MDPI AG |
publishDate |
2017 |
url |
https://doi.org/10.3390/ijms18122554 https://doaj.org/article/21a95dd729b64abb9050d40e3004dbda |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill Euphausia superba |
genre_facet |
Antarc* Antarctic Antarctic Krill Euphausia superba |
op_source |
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2554 (2017) |
op_relation |
https://www.mdpi.com/1422-0067/18/12/2554 https://doaj.org/toc/1422-0067 1422-0067 doi:10.3390/ijms18122554 https://doaj.org/article/21a95dd729b64abb9050d40e3004dbda |
op_doi |
https://doi.org/10.3390/ijms18122554 |
container_title |
International Journal of Molecular Sciences |
container_volume |
18 |
container_issue |
12 |
container_start_page |
2554 |
_version_ |
1766257107227639808 |