Detection of HIV-1 infections in blood donors during the pre-seroconversion window period in São Paulo, Brazil

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Nanci Alves Salles, Anna Shoko Nishiya, Suzete Cleusa Ferreira, Vanderson Geraldo Rocha, Alfredo Mendrone-Junior
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019
• Subjects: HIV; NAT-HIV; Window period; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0432-2018; https://doaj.org/article/21a3a9bab44f4730a1b710715a180710

Abstract By decreasing the pre-seroconversion window period, nucleic acid testing (NAT) has improved the safety of blood products and reduced the risk of transfusion-transmitted infections. Between 2011 and 2017, NAT determinations for approximately 898,202 donations were performed at Fundação Pró-Sangue/Hemocentro de São Paulo (FPS-HSP). Three seronegative HIV-viremic donations were detected. The NAT yield rate per million donations was 3.34 for HIV, and the acute HIV-1 infections detected are described, followed by a brief review of the situation in Brazil.