Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos
The cardiac effects of experimentally induced myocarditis, when the parasite is obtained from mouse blood, are well known. However, the consequences of the infection when the parasites are obtained from bug faeces are less well defined. In the present investigation, we have used the "Y" st...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2000
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Online Access: | https://doi.org/10.1590/S0037-86822000000600003 https://doaj.org/article/21a30c3a5b33450da1d7f800259e33c0 |
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ftdoajarticles:oai:doaj.org/article:21a30c3a5b33450da1d7f800259e33c0 2023-05-15T15:19:02+02:00 Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos Adalinda Ollarves Diego F. Dávila Carlos F. Gottberg Paolo Ramoni-Perazzi 2000-12-01T00:00:00Z https://doi.org/10.1590/S0037-86822000000600003 https://doaj.org/article/21a30c3a5b33450da1d7f800259e33c0 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822000000600003 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822000000600003 0037-8682 1678-9849 https://doaj.org/article/21a30c3a5b33450da1d7f800259e33c0 Revista da Sociedade Brasileira de Medicina Tropical, Vol 33, Iss 6, Pp 529-533 (2000) Trypanosoma cruzi Infecção conjuntival Infecção chagásica experimental Ritmo cardíaco Disfunção autonômica Conjunctival infection Experimental Chagas' infection Heart rate Autonomic dysfunction Arctic medicine. Tropical medicine RC955-962 article 2000 ftdoajarticles https://doi.org/10.1590/S0037-86822000000600003 2022-12-31T03:21:41Z The cardiac effects of experimentally induced myocarditis, when the parasite is obtained from mouse blood, are well known. However, the consequences of the infection when the parasites are obtained from bug faeces are less well defined. In the present investigation, we have used the "Y" strain of Trypanosoma cruzi, which was maintained in Rhodnius prolixus by repeated passages in mice. The faeces of 30 infected bugs were collected, the number of parasites counted and 4,000 parasites inoculated by the conjunctival route in 60 rats. Twenty-nine other rats received faeces from noninfected bugs (sham-inoculated controls) and 40 were used as normal controls. The heart rate of the three groups of animals was recorded under general anesthesia with ether. The heart rate, at day 0 pre-inoculation, was similar in the three groups of animals (Controls: 379 ± 27 beats/min Mean ± SD; Sham-inoculated: 366 ± 31; Infected: 351 ± 29) (p> 0.05). In the infected animals, the mean heart rate began to increase significantly by day 12 following infection (375 ± 31), reaching the highest values between days 18 (390 ± 33) and 21 (403 ± 33) and returned to baseline by day 30 (359 ± 28) (p< 0.05). The heart rate changes were statistically different from those observed in the sham-inoculated controls and in the control animals. Therefore, these heart rate changes were provoked by the Trypanosoma cruzi-induced infection. Thus, it appears that irrespective of the source of the parasite and route of inoculation Trypanosoma cruziacute infection provokes a transient sinus tachycardia. Os efeitos da miocardite chagásica experimental, produzida por Trypanosoma cruzi proveniente do sangue de camundongos são bem conhecidos. O mesmo não ocorre quando a inoculação é feita com Trypanosoma cruzi proveniente de fezes do vetor. No presente estudo, usamos a variedade "Y" do Trypanosoma cruzi mantida em Rodhnius prolixus por repetidas passagens em camundongos. As fezes de 30 insetos parasitados foram coletadas e contados os parasitas. O estudo foi ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) Revista da Sociedade Brasileira de Medicina Tropical 33 6 529 533 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Trypanosoma cruzi Infecção conjuntival Infecção chagásica experimental Ritmo cardíaco Disfunção autonômica Conjunctival infection Experimental Chagas' infection Heart rate Autonomic dysfunction Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Trypanosoma cruzi Infecção conjuntival Infecção chagásica experimental Ritmo cardíaco Disfunção autonômica Conjunctival infection Experimental Chagas' infection Heart rate Autonomic dysfunction Arctic medicine. Tropical medicine RC955-962 Adalinda Ollarves Diego F. Dávila Carlos F. Gottberg Paolo Ramoni-Perazzi Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos |
topic_facet |
Trypanosoma cruzi Infecção conjuntival Infecção chagásica experimental Ritmo cardíaco Disfunção autonômica Conjunctival infection Experimental Chagas' infection Heart rate Autonomic dysfunction Arctic medicine. Tropical medicine RC955-962 |
description |
The cardiac effects of experimentally induced myocarditis, when the parasite is obtained from mouse blood, are well known. However, the consequences of the infection when the parasites are obtained from bug faeces are less well defined. In the present investigation, we have used the "Y" strain of Trypanosoma cruzi, which was maintained in Rhodnius prolixus by repeated passages in mice. The faeces of 30 infected bugs were collected, the number of parasites counted and 4,000 parasites inoculated by the conjunctival route in 60 rats. Twenty-nine other rats received faeces from noninfected bugs (sham-inoculated controls) and 40 were used as normal controls. The heart rate of the three groups of animals was recorded under general anesthesia with ether. The heart rate, at day 0 pre-inoculation, was similar in the three groups of animals (Controls: 379 ± 27 beats/min Mean ± SD; Sham-inoculated: 366 ± 31; Infected: 351 ± 29) (p> 0.05). In the infected animals, the mean heart rate began to increase significantly by day 12 following infection (375 ± 31), reaching the highest values between days 18 (390 ± 33) and 21 (403 ± 33) and returned to baseline by day 30 (359 ± 28) (p< 0.05). The heart rate changes were statistically different from those observed in the sham-inoculated controls and in the control animals. Therefore, these heart rate changes were provoked by the Trypanosoma cruzi-induced infection. Thus, it appears that irrespective of the source of the parasite and route of inoculation Trypanosoma cruziacute infection provokes a transient sinus tachycardia. Os efeitos da miocardite chagásica experimental, produzida por Trypanosoma cruzi proveniente do sangue de camundongos são bem conhecidos. O mesmo não ocorre quando a inoculação é feita com Trypanosoma cruzi proveniente de fezes do vetor. No presente estudo, usamos a variedade "Y" do Trypanosoma cruzi mantida em Rodhnius prolixus por repetidas passagens em camundongos. As fezes de 30 insetos parasitados foram coletadas e contados os parasitas. O estudo foi ... |
format |
Article in Journal/Newspaper |
author |
Adalinda Ollarves Diego F. Dávila Carlos F. Gottberg Paolo Ramoni-Perazzi |
author_facet |
Adalinda Ollarves Diego F. Dávila Carlos F. Gottberg Paolo Ramoni-Perazzi |
author_sort |
Adalinda Ollarves |
title |
Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos |
title_short |
Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos |
title_full |
Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos |
title_fullStr |
Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos |
title_full_unstemmed |
Serial heart rate changes in rats inoculated by conjunctival instillation of Trypanosoma cruzi obtained from bug faeces Alterações do ritmo cardíaco de ratos infectados pela via conjuntival por Trypanosoma cruzi obtidos de fezes de triatomíneos |
title_sort |
serial heart rate changes in rats inoculated by conjunctival instillation of trypanosoma cruzi obtained from bug faeces alterações do ritmo cardíaco de ratos infectados pela via conjuntival por trypanosoma cruzi obtidos de fezes de triatomíneos |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2000 |
url |
https://doi.org/10.1590/S0037-86822000000600003 https://doaj.org/article/21a30c3a5b33450da1d7f800259e33c0 |
long_lat |
ENVELOPE(-112.453,-112.453,57.591,57.591) |
geographic |
Arctic The ''Y'' |
geographic_facet |
Arctic The ''Y'' |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 33, Iss 6, Pp 529-533 (2000) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822000000600003 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822000000600003 0037-8682 1678-9849 https://doaj.org/article/21a30c3a5b33450da1d7f800259e33c0 |
op_doi |
https://doi.org/10.1590/S0037-86822000000600003 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
33 |
container_issue |
6 |
container_start_page |
529 |
op_container_end_page |
533 |
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