Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011
Abstract Background The northern territory Nunavut has Canada’s largest jurisdictional land mass with 33,322 inhabitants, of which 85% self-identify as Inuit. Nunavut has rates of infant mortality, postneonatal mortality and hospitalisation of infants for respiratory infections that greatly exceed t...
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ftdoajarticles:oai:doaj.org/article:213728beeede41b7b7c7952c968a9ca6 2023-05-15T16:17:11+02:00 Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 Collins Sorcha A Surmala Padma Osborne Geraldine Greenberg Cheryl Bathory Laakkuluk Edmunds-Potvin Sharon Arbour Laura 2012-12-01T00:00:00Z https://doi.org/10.1186/1471-2431-12-190 https://doaj.org/article/213728beeede41b7b7c7952c968a9ca6 EN eng BMC http://www.biomedcentral.com/1471-2431/12/190 https://doaj.org/toc/1471-2431 doi:10.1186/1471-2431-12-190 1471-2431 https://doaj.org/article/213728beeede41b7b7c7952c968a9ca6 BMC Pediatrics, Vol 12, Iss 1, p 190 (2012) Inuit Nunavut Aboriginal Infant mortality Sudden infant death syndrome Sudden unexpected death in infancy Carnitine palmitoyltransferase 1 deficiency CPT1A P479L variant Pediatrics RJ1-570 article 2012 ftdoajarticles https://doi.org/10.1186/1471-2431-12-190 2022-12-31T08:47:33Z Abstract Background The northern territory Nunavut has Canada’s largest jurisdictional land mass with 33,322 inhabitants, of which 85% self-identify as Inuit. Nunavut has rates of infant mortality, postneonatal mortality and hospitalisation of infants for respiratory infections that greatly exceed those for the rest of Canada. The infant mortality rate in Nunavut is 3 times the national average, and twice that of the neighbouring territory, the Northwest Territories. Nunavut has the largest Inuit population in Canada, a population which has been identified as having high rates of Sudden Infant Death Syndrome (SIDS) and infant deaths due to infections. Methods To determine the causes and potential risk factors of infant mortality in Nunavut, we reviewed all infant deaths (<1yr) documented by the Nunavut Chief Coroner’s Office and the Nunavut Bureau of Statistics (n=117; 1999–2011). Rates were compared to published data for Canada. Results Sudden death in infancy (SIDS/SUDI; 48%) and infection (21%) were the leading causes of infant death, with rates significantly higher than for Canada (2003–2007). Of SIDS/SUDI cases with information on sleep position (n=42) and bed-sharing (n=47), 29 (69%) were sleeping non-supine and 33 (70%) were bed-sharing. Of those bed-sharing, 23 (70%) had two or more additional risk factors present, usually non-supine sleep position. CPT1A P479L homozygosity, which has been previously associated with infant mortality in Alaska Native and British Columbia First Nations populations, was associated with unexpected infant death (SIDS/SUDI, infection) throughout Nunavut (OR:3.43, 95% CI:1.30-11.47). Conclusion Unexpected infant deaths comprise the majority of infant deaths in Nunavut. Although the CPT1A P479L variant was associated with unexpected infant death in Nunavut as a whole, the association was less apparent when population stratification was considered. Strategies to promote safe sleep practices and further understand other potential risk factors for infant mortality (P479L ... Article in Journal/Newspaper First Nations inuit Northwest Territories Nunavut Alaska Directory of Open Access Journals: DOAJ Articles Nunavut Northwest Territories Canada British Columbia ENVELOPE(-125.003,-125.003,54.000,54.000) BMC Pediatrics 12 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Inuit Nunavut Aboriginal Infant mortality Sudden infant death syndrome Sudden unexpected death in infancy Carnitine palmitoyltransferase 1 deficiency CPT1A P479L variant Pediatrics RJ1-570 |
spellingShingle |
Inuit Nunavut Aboriginal Infant mortality Sudden infant death syndrome Sudden unexpected death in infancy Carnitine palmitoyltransferase 1 deficiency CPT1A P479L variant Pediatrics RJ1-570 Collins Sorcha A Surmala Padma Osborne Geraldine Greenberg Cheryl Bathory Laakkuluk Edmunds-Potvin Sharon Arbour Laura Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 |
topic_facet |
Inuit Nunavut Aboriginal Infant mortality Sudden infant death syndrome Sudden unexpected death in infancy Carnitine palmitoyltransferase 1 deficiency CPT1A P479L variant Pediatrics RJ1-570 |
description |
Abstract Background The northern territory Nunavut has Canada’s largest jurisdictional land mass with 33,322 inhabitants, of which 85% self-identify as Inuit. Nunavut has rates of infant mortality, postneonatal mortality and hospitalisation of infants for respiratory infections that greatly exceed those for the rest of Canada. The infant mortality rate in Nunavut is 3 times the national average, and twice that of the neighbouring territory, the Northwest Territories. Nunavut has the largest Inuit population in Canada, a population which has been identified as having high rates of Sudden Infant Death Syndrome (SIDS) and infant deaths due to infections. Methods To determine the causes and potential risk factors of infant mortality in Nunavut, we reviewed all infant deaths (<1yr) documented by the Nunavut Chief Coroner’s Office and the Nunavut Bureau of Statistics (n=117; 1999–2011). Rates were compared to published data for Canada. Results Sudden death in infancy (SIDS/SUDI; 48%) and infection (21%) were the leading causes of infant death, with rates significantly higher than for Canada (2003–2007). Of SIDS/SUDI cases with information on sleep position (n=42) and bed-sharing (n=47), 29 (69%) were sleeping non-supine and 33 (70%) were bed-sharing. Of those bed-sharing, 23 (70%) had two or more additional risk factors present, usually non-supine sleep position. CPT1A P479L homozygosity, which has been previously associated with infant mortality in Alaska Native and British Columbia First Nations populations, was associated with unexpected infant death (SIDS/SUDI, infection) throughout Nunavut (OR:3.43, 95% CI:1.30-11.47). Conclusion Unexpected infant deaths comprise the majority of infant deaths in Nunavut. Although the CPT1A P479L variant was associated with unexpected infant death in Nunavut as a whole, the association was less apparent when population stratification was considered. Strategies to promote safe sleep practices and further understand other potential risk factors for infant mortality (P479L ... |
format |
Article in Journal/Newspaper |
author |
Collins Sorcha A Surmala Padma Osborne Geraldine Greenberg Cheryl Bathory Laakkuluk Edmunds-Potvin Sharon Arbour Laura |
author_facet |
Collins Sorcha A Surmala Padma Osborne Geraldine Greenberg Cheryl Bathory Laakkuluk Edmunds-Potvin Sharon Arbour Laura |
author_sort |
Collins Sorcha A |
title |
Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 |
title_short |
Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 |
title_full |
Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 |
title_fullStr |
Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 |
title_full_unstemmed |
Causes and risk factors for infant mortality in Nunavut, Canada 1999–2011 |
title_sort |
causes and risk factors for infant mortality in nunavut, canada 1999–2011 |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1471-2431-12-190 https://doaj.org/article/213728beeede41b7b7c7952c968a9ca6 |
long_lat |
ENVELOPE(-125.003,-125.003,54.000,54.000) |
geographic |
Nunavut Northwest Territories Canada British Columbia |
geographic_facet |
Nunavut Northwest Territories Canada British Columbia |
genre |
First Nations inuit Northwest Territories Nunavut Alaska |
genre_facet |
First Nations inuit Northwest Territories Nunavut Alaska |
op_source |
BMC Pediatrics, Vol 12, Iss 1, p 190 (2012) |
op_relation |
http://www.biomedcentral.com/1471-2431/12/190 https://doaj.org/toc/1471-2431 doi:10.1186/1471-2431-12-190 1471-2431 https://doaj.org/article/213728beeede41b7b7c7952c968a9ca6 |
op_doi |
https://doi.org/10.1186/1471-2431-12-190 |
container_title |
BMC Pediatrics |
container_volume |
12 |
container_issue |
1 |
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1766003032121671680 |