Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence
Meningitis causes significant morbidity and mortality globally. The aim of this study was to study the clinical presentation, aetiology, and outcomes of meningitis among adult patients admitted to Queen Mamohato Memorial Hospital in Maseru, Lesotho, with a diagnosis of meningitis. A cross-sectional...
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ftdoajarticles:oai:doaj.org/article:2125e5fc914643aba6db48305c9c8347 2023-05-15T15:07:55+02:00 Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence Keneuoe Hycianth Thinyane Keanole Mofona Motsemme Varsay Jim Lahai Cooper 2015-01-01T00:00:00Z https://doi.org/10.1155/2015/423161 https://doaj.org/article/2125e5fc914643aba6db48305c9c8347 EN eng Hindawi Limited http://dx.doi.org/10.1155/2015/423161 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/423161 https://doaj.org/article/2125e5fc914643aba6db48305c9c8347 Journal of Tropical Medicine, Vol 2015 (2015) Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1155/2015/423161 2022-12-31T13:33:39Z Meningitis causes significant morbidity and mortality globally. The aim of this study was to study the clinical presentation, aetiology, and outcomes of meningitis among adult patients admitted to Queen Mamohato Memorial Hospital in Maseru, Lesotho, with a diagnosis of meningitis. A cross-sectional study was conducted between February and April 2014; data collected included presenting signs and symptoms, laboratory results, and clinical outcomes. Descriptive statistics were used to summarise data; association between variables was analysed using Fisher’s exact test. 56 patients were enrolled; the HIV coinfection rate was 79%. The most common presenting symptoms were altered mental status, neck stiffness, headache, and fever. TB meningitis was the most frequent diagnosis (39%), followed by bacterial (27%), viral (18%), and cryptococcal meningitis (16%). In-hospital mortality was 43% with case fatalities of 23%, 40%, 44%, and 90% for TB, bacterial, cryptococcal, and viral meningitis, respectively. Severe renal impairment was significantly associated with mortality. In conclusion, the causes of meningitis in this study reflect the high prevalence of HIV and TB in our setting. Strategies to reduce morbidity and mortality due to meningitis should include improving diagnostic services to facilitate early detection and treatment of meningitis and timely initiation of antiretroviral therapy in HIV-infected patients. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2015 1 7 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Keneuoe Hycianth Thinyane Keanole Mofona Motsemme Varsay Jim Lahai Cooper Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Meningitis causes significant morbidity and mortality globally. The aim of this study was to study the clinical presentation, aetiology, and outcomes of meningitis among adult patients admitted to Queen Mamohato Memorial Hospital in Maseru, Lesotho, with a diagnosis of meningitis. A cross-sectional study was conducted between February and April 2014; data collected included presenting signs and symptoms, laboratory results, and clinical outcomes. Descriptive statistics were used to summarise data; association between variables was analysed using Fisher’s exact test. 56 patients were enrolled; the HIV coinfection rate was 79%. The most common presenting symptoms were altered mental status, neck stiffness, headache, and fever. TB meningitis was the most frequent diagnosis (39%), followed by bacterial (27%), viral (18%), and cryptococcal meningitis (16%). In-hospital mortality was 43% with case fatalities of 23%, 40%, 44%, and 90% for TB, bacterial, cryptococcal, and viral meningitis, respectively. Severe renal impairment was significantly associated with mortality. In conclusion, the causes of meningitis in this study reflect the high prevalence of HIV and TB in our setting. Strategies to reduce morbidity and mortality due to meningitis should include improving diagnostic services to facilitate early detection and treatment of meningitis and timely initiation of antiretroviral therapy in HIV-infected patients. |
format |
Article in Journal/Newspaper |
author |
Keneuoe Hycianth Thinyane Keanole Mofona Motsemme Varsay Jim Lahai Cooper |
author_facet |
Keneuoe Hycianth Thinyane Keanole Mofona Motsemme Varsay Jim Lahai Cooper |
author_sort |
Keneuoe Hycianth Thinyane |
title |
Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence |
title_short |
Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence |
title_full |
Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence |
title_fullStr |
Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence |
title_full_unstemmed |
Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence |
title_sort |
clinical presentation, aetiology, and outcomes of meningitis in a setting of high hiv and tb prevalence |
publisher |
Hindawi Limited |
publishDate |
2015 |
url |
https://doi.org/10.1155/2015/423161 https://doaj.org/article/2125e5fc914643aba6db48305c9c8347 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2015 (2015) |
op_relation |
http://dx.doi.org/10.1155/2015/423161 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/423161 https://doaj.org/article/2125e5fc914643aba6db48305c9c8347 |
op_doi |
https://doi.org/10.1155/2015/423161 |
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Journal of Tropical Medicine |
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2015 |
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1 |
op_container_end_page |
7 |
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1766339352702484480 |