Clinically unapparent infantile thiamin deficiency in Vientiane, Laos.
Background Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome. Methodology/principal findings A cohort of 778 sick infants admitted...
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2011
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ftdoajarticles:oai:doaj.org/article:20e0b7ac3fe342aa8ddccda259515dcb 2023-05-15T15:09:26+02:00 Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. Sengmanivong Khounnorath Karen Chamberlain Ann M Taylor Douangdao Soukaloun Mayfong Mayxay Sue J Lee Bounthom Phengdy Khonsavanh Luangxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Nicholas J White Paul N Newton 2011-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000969 https://doaj.org/article/20e0b7ac3fe342aa8ddccda259515dcb EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21423705/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000969 https://doaj.org/article/20e0b7ac3fe342aa8ddccda259515dcb PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e969 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000969 2022-12-31T16:29:04Z Background Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome. Methodology/principal findings A cohort of 778 sick infants admitted during one year without clinical evidence of beriberi were studied prospectively and erythrocyte transketolase assays (ETK) performed. Biochemical thiamin deficiency was defined both in terms of the activation coefficient (α>31%) and basal ETK activity <0.59 micromoles/min/gHb. Of the 778 infants, median (range) age was 5 (0-12) months, 79.2% were breastfed, 5.1% had α>31% and 13.4 % basal ETK<0.59 micromoles/min/gHb. Infants≥2 months old had a higher frequency of biochemical markers of thiamin deficiency. Mortality was 5.5% but, among infants ≥2 months old, mortality was higher in those with basal ETK<0.59 micromoles/min/gHb (3/47, 6.4%) than in those with basal ETK≥0.59 micromoles/min/gHb (1/146, 0.7%) (P=0.045, relative risk=9.32 (95%CI 0.99 to 87.5)). Multivariate regression analysis indicated that infant age≥2 months and fewer maternal years of schooling were independently associated with infant basal ETK<0.59 micromoles/min/gHb. Conclusions/significance Clinically unapparent thiamin deficiency is common among sick infants (≥2 months old) admitted to hospital in Vientiane. This may contribute to mortality and a low clinical threshold for providing thiamin to sick infants may be needed. Article in Journal/Newspaper Arctic Iceberg* Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 2 e969 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sengmanivong Khounnorath Karen Chamberlain Ann M Taylor Douangdao Soukaloun Mayfong Mayxay Sue J Lee Bounthom Phengdy Khonsavanh Luangxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Nicholas J White Paul N Newton Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome. Methodology/principal findings A cohort of 778 sick infants admitted during one year without clinical evidence of beriberi were studied prospectively and erythrocyte transketolase assays (ETK) performed. Biochemical thiamin deficiency was defined both in terms of the activation coefficient (α>31%) and basal ETK activity <0.59 micromoles/min/gHb. Of the 778 infants, median (range) age was 5 (0-12) months, 79.2% were breastfed, 5.1% had α>31% and 13.4 % basal ETK<0.59 micromoles/min/gHb. Infants≥2 months old had a higher frequency of biochemical markers of thiamin deficiency. Mortality was 5.5% but, among infants ≥2 months old, mortality was higher in those with basal ETK<0.59 micromoles/min/gHb (3/47, 6.4%) than in those with basal ETK≥0.59 micromoles/min/gHb (1/146, 0.7%) (P=0.045, relative risk=9.32 (95%CI 0.99 to 87.5)). Multivariate regression analysis indicated that infant age≥2 months and fewer maternal years of schooling were independently associated with infant basal ETK<0.59 micromoles/min/gHb. Conclusions/significance Clinically unapparent thiamin deficiency is common among sick infants (≥2 months old) admitted to hospital in Vientiane. This may contribute to mortality and a low clinical threshold for providing thiamin to sick infants may be needed. |
format |
Article in Journal/Newspaper |
author |
Sengmanivong Khounnorath Karen Chamberlain Ann M Taylor Douangdao Soukaloun Mayfong Mayxay Sue J Lee Bounthom Phengdy Khonsavanh Luangxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Nicholas J White Paul N Newton |
author_facet |
Sengmanivong Khounnorath Karen Chamberlain Ann M Taylor Douangdao Soukaloun Mayfong Mayxay Sue J Lee Bounthom Phengdy Khonsavanh Luangxay Kongkham Sisouk Bandit Soumphonphakdy Khaysy Latsavong Kongsin Akkhavong Nicholas J White Paul N Newton |
author_sort |
Sengmanivong Khounnorath |
title |
Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. |
title_short |
Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. |
title_full |
Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. |
title_fullStr |
Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. |
title_full_unstemmed |
Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. |
title_sort |
clinically unapparent infantile thiamin deficiency in vientiane, laos. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0000969 https://doaj.org/article/20e0b7ac3fe342aa8ddccda259515dcb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Iceberg* |
genre_facet |
Arctic Iceberg* |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e969 (2011) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21423705/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000969 https://doaj.org/article/20e0b7ac3fe342aa8ddccda259515dcb |
op_doi |
https://doi.org/10.1371/journal.pntd.0000969 |
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PLoS Neglected Tropical Diseases |
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5 |
container_issue |
2 |
container_start_page |
e969 |
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1766340636119662592 |