Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015).
BACKGROUND:Plague, a Yersinia pestis infection, is a fatal disease with tremendous transmission capacity. However, the mechanism of how the pathogen stays in a reservoir, circulates and then re-emerges is an enigma. METHODOLOGY/PRINCIPAL FINDINGS:We studied a plague outbreak caused by the constructi...
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ftdoajarticles:oai:doaj.org/article:20d66b07ef6c4818aae540c56e1939ef 2023-05-15T15:13:11+02:00 Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). Xin Wang Xiaoyu Wei Zhizhong Song Mingliu Wang Jinxiao Xi Junrong Liang Yun Liang Ran Duan Kecheng Tian Yong Zhao Guangpeng Tang Lv You Guirong Yang Xuebin Liu Yuhuang Chen Jun Zeng Shengrong Wu Shoujun Luo Gang Qin Huijing Hao Huaiqi Jing 2017-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005425 https://doaj.org/article/20d66b07ef6c4818aae540c56e1939ef EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5352140?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005425 https://doaj.org/article/20d66b07ef6c4818aae540c56e1939ef PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005425 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005425 2023-01-08T01:25:34Z BACKGROUND:Plague, a Yersinia pestis infection, is a fatal disease with tremendous transmission capacity. However, the mechanism of how the pathogen stays in a reservoir, circulates and then re-emerges is an enigma. METHODOLOGY/PRINCIPAL FINDINGS:We studied a plague outbreak caused by the construction of a large reservoir in southwest China followed 16-years' surveillance. CONCLUSIONS/SIGNIFICANCE:The results show the prevalence of plague within the natural plague focus is closely related to the stability of local ecology. Before and during the decade of construction the reservoir on the Nanpan River, no confirmed plague has ever emerged. With the impoundment of reservoir and destruction of drowned farmland and vegetation, the infected rodent population previously dispersed was concentrated together in a flood-free area and turned a rest focus alive. Human plague broke out after the enzootic plague via the flea bite. With the construction completed and ecology gradually of human residential environment, animal population and type of vegetation settling down to a new balance, the natural plague foci returned to a rest period. With the rodent density decreased as some of them died, the flea density increased as the rodents lived near or in local farm houses where had more domestic animals, and human has a more concentrated population. In contrast, in the Himalayan marmot foci of the Qinghai-Tibet Plateau in the Qilian Mountains. There are few human inhabitants and the local ecology is relatively stable; plague is prevalence, showing no rest period. Thus the plague can be significantly affected by ecological shifts. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 3 e0005425 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xin Wang Xiaoyu Wei Zhizhong Song Mingliu Wang Jinxiao Xi Junrong Liang Yun Liang Ran Duan Kecheng Tian Yong Zhao Guangpeng Tang Lv You Guirong Yang Xuebin Liu Yuhuang Chen Jun Zeng Shengrong Wu Shoujun Luo Gang Qin Huijing Hao Huaiqi Jing Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Plague, a Yersinia pestis infection, is a fatal disease with tremendous transmission capacity. However, the mechanism of how the pathogen stays in a reservoir, circulates and then re-emerges is an enigma. METHODOLOGY/PRINCIPAL FINDINGS:We studied a plague outbreak caused by the construction of a large reservoir in southwest China followed 16-years' surveillance. CONCLUSIONS/SIGNIFICANCE:The results show the prevalence of plague within the natural plague focus is closely related to the stability of local ecology. Before and during the decade of construction the reservoir on the Nanpan River, no confirmed plague has ever emerged. With the impoundment of reservoir and destruction of drowned farmland and vegetation, the infected rodent population previously dispersed was concentrated together in a flood-free area and turned a rest focus alive. Human plague broke out after the enzootic plague via the flea bite. With the construction completed and ecology gradually of human residential environment, animal population and type of vegetation settling down to a new balance, the natural plague foci returned to a rest period. With the rodent density decreased as some of them died, the flea density increased as the rodents lived near or in local farm houses where had more domestic animals, and human has a more concentrated population. In contrast, in the Himalayan marmot foci of the Qinghai-Tibet Plateau in the Qilian Mountains. There are few human inhabitants and the local ecology is relatively stable; plague is prevalence, showing no rest period. Thus the plague can be significantly affected by ecological shifts. |
format |
Article in Journal/Newspaper |
author |
Xin Wang Xiaoyu Wei Zhizhong Song Mingliu Wang Jinxiao Xi Junrong Liang Yun Liang Ran Duan Kecheng Tian Yong Zhao Guangpeng Tang Lv You Guirong Yang Xuebin Liu Yuhuang Chen Jun Zeng Shengrong Wu Shoujun Luo Gang Qin Huijing Hao Huaiqi Jing |
author_facet |
Xin Wang Xiaoyu Wei Zhizhong Song Mingliu Wang Jinxiao Xi Junrong Liang Yun Liang Ran Duan Kecheng Tian Yong Zhao Guangpeng Tang Lv You Guirong Yang Xuebin Liu Yuhuang Chen Jun Zeng Shengrong Wu Shoujun Luo Gang Qin Huijing Hao Huaiqi Jing |
author_sort |
Xin Wang |
title |
Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). |
title_short |
Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). |
title_full |
Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). |
title_fullStr |
Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). |
title_full_unstemmed |
Mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). |
title_sort |
mechanism study on a plague outbreak driven by the construction of a large reservoir in southwest china (surveillance from 2000-2015). |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005425 https://doaj.org/article/20d66b07ef6c4818aae540c56e1939ef |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005425 (2017) |
op_relation |
http://europepmc.org/articles/PMC5352140?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005425 https://doaj.org/article/20d66b07ef6c4818aae540c56e1939ef |
op_doi |
https://doi.org/10.1371/journal.pntd.0005425 |
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PLOS Neglected Tropical Diseases |
container_volume |
11 |
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3 |
container_start_page |
e0005425 |
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