Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Amanda Alves Fecury, Marcella Kelly Costa de Almeida, Kemper Nunes dos Santos, Andrei da Silva Freitas, Socorro de Fátima Loureiro Dantas, Carlos Araújo da Costa, Ângelo Barlleta Crescente, Rita Catarina Medeiros de Sousa, Elza Baía de Brito, Reza Nassiri, Elizabeth Lampe, Luisa Caricio Martins
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2014
• Subjects: Hepatitis C virus; Genotype; Histopathology; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0008-2012; https://doaj.org/article/2094ac5d8ca74df2b84fc4fc89a3cde9

Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.