NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population

Abstract Aims The aim of this study was to establish age‐specific and sex‐specific cut‐off values for N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and high‐sensitivity troponin T (hs‐troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failur...

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Published in:ESC Heart Failure
Main Authors: Maria Averina, Michael Stylidis, Jan Brox, Henrik Schirmer
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2022
Subjects:
Online Access:https://doi.org/10.1002/ehf2.13906
https://doaj.org/article/20945f236ab7477fac2638e3d2c28b11
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spelling ftdoajarticles:oai:doaj.org/article:20945f236ab7477fac2638e3d2c28b11 2023-05-15T17:43:38+02:00 NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population Maria Averina Michael Stylidis Jan Brox Henrik Schirmer 2022-06-01T00:00:00Z https://doi.org/10.1002/ehf2.13906 https://doaj.org/article/20945f236ab7477fac2638e3d2c28b11 EN eng Wiley https://doi.org/10.1002/ehf2.13906 https://doaj.org/toc/2055-5822 2055-5822 doi:10.1002/ehf2.13906 https://doaj.org/article/20945f236ab7477fac2638e3d2c28b11 ESC Heart Failure, Vol 9, Iss 3, Pp 1954-1962 (2022) Cardiac markers Heart failure Reference intervals Epidemiology studies Diseases of the circulatory (Cardiovascular) system RC666-701 article 2022 ftdoajarticles https://doi.org/10.1002/ehf2.13906 2022-12-31T02:24:08Z Abstract Aims The aim of this study was to establish age‐specific and sex‐specific cut‐off values for N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and high‐sensitivity troponin T (hs‐troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population. Methods and results Altogether, 1936 participants were randomly selected from the general population Tromsø 7 study in Northern Norway. Diagnostic accuracy (sensitivity, specificity, and negative and positive predictive value) of cardiac markers for echocardiographically defined subclinical HF was evaluated. The receiver‐operating characteristic analysis showed that areas under the curve were relatively low (under 0.75) for both NT‐proBNP and hs‐troponin T, suggesting that the diagnostic accuracy of these biomarkers for subclinical HF was not excellent, especially for mild forms of HF and younger age group 40–49 years. Sex‐specific and age‐specific cut‐offs for hs‐troponin T (99th percentiles) and NT‐proBNP (97.5th percentiles) were established in healthy subjects from the same general population. The sex‐specific and age‐specific cut‐offs for NT‐proBNP had higher specificity for subclinical HF compared with the previously established single cut‐off 125 pg/mL. Age‐specific cut‐off for hs‐troponin T (18 ng/L) for men ≥60 years had also higher specificity than the single cut‐off 14 ng/L. These cut‐offs had high specificity, but low sensitivity, that makes hs‐troponin T and NT‐proBNP good biomarkers to rule in HF in case of a positive test, but not good enough to rule out all unrecognized HF due to false negative results. Conclusions N‐terminal pro‐brain natriuretic peptide and hs‐troponin T are suboptimal screening tools for subclinical HF in a general population due to low sensitivity. Article in Journal/Newspaper Northern Norway Tromsø Directory of Open Access Journals: DOAJ Articles Norway Tromsø ESC Heart Failure 9 3 1954 1962
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Cardiac markers
Heart failure
Reference intervals
Epidemiology studies
Diseases of the circulatory (Cardiovascular) system
RC666-701
spellingShingle Cardiac markers
Heart failure
Reference intervals
Epidemiology studies
Diseases of the circulatory (Cardiovascular) system
RC666-701
Maria Averina
Michael Stylidis
Jan Brox
Henrik Schirmer
NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
topic_facet Cardiac markers
Heart failure
Reference intervals
Epidemiology studies
Diseases of the circulatory (Cardiovascular) system
RC666-701
description Abstract Aims The aim of this study was to establish age‐specific and sex‐specific cut‐off values for N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and high‐sensitivity troponin T (hs‐troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population. Methods and results Altogether, 1936 participants were randomly selected from the general population Tromsø 7 study in Northern Norway. Diagnostic accuracy (sensitivity, specificity, and negative and positive predictive value) of cardiac markers for echocardiographically defined subclinical HF was evaluated. The receiver‐operating characteristic analysis showed that areas under the curve were relatively low (under 0.75) for both NT‐proBNP and hs‐troponin T, suggesting that the diagnostic accuracy of these biomarkers for subclinical HF was not excellent, especially for mild forms of HF and younger age group 40–49 years. Sex‐specific and age‐specific cut‐offs for hs‐troponin T (99th percentiles) and NT‐proBNP (97.5th percentiles) were established in healthy subjects from the same general population. The sex‐specific and age‐specific cut‐offs for NT‐proBNP had higher specificity for subclinical HF compared with the previously established single cut‐off 125 pg/mL. Age‐specific cut‐off for hs‐troponin T (18 ng/L) for men ≥60 years had also higher specificity than the single cut‐off 14 ng/L. These cut‐offs had high specificity, but low sensitivity, that makes hs‐troponin T and NT‐proBNP good biomarkers to rule in HF in case of a positive test, but not good enough to rule out all unrecognized HF due to false negative results. Conclusions N‐terminal pro‐brain natriuretic peptide and hs‐troponin T are suboptimal screening tools for subclinical HF in a general population due to low sensitivity.
format Article in Journal/Newspaper
author Maria Averina
Michael Stylidis
Jan Brox
Henrik Schirmer
author_facet Maria Averina
Michael Stylidis
Jan Brox
Henrik Schirmer
author_sort Maria Averina
title NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
title_short NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
title_full NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
title_fullStr NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
title_full_unstemmed NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population
title_sort nt‐probnp and high‐sensitivity troponin t as screening tests for subclinical chronic heart failure in a general population
publisher Wiley
publishDate 2022
url https://doi.org/10.1002/ehf2.13906
https://doaj.org/article/20945f236ab7477fac2638e3d2c28b11
geographic Norway
Tromsø
geographic_facet Norway
Tromsø
genre Northern Norway
Tromsø
genre_facet Northern Norway
Tromsø
op_source ESC Heart Failure, Vol 9, Iss 3, Pp 1954-1962 (2022)
op_relation https://doi.org/10.1002/ehf2.13906
https://doaj.org/toc/2055-5822
2055-5822
doi:10.1002/ehf2.13906
https://doaj.org/article/20945f236ab7477fac2638e3d2c28b11
op_doi https://doi.org/10.1002/ehf2.13906
container_title ESC Heart Failure
container_volume 9
container_issue 3
container_start_page 1954
op_container_end_page 1962
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