Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016.
Background In the French Territories in the Americas (FTA), the risk of birth defects possibly associated with Zika virus (ZIKV) infection was 7.0% (95%CI: 5.0 to 9.5) among foetuses/infants of 546 women with symptomatic RT-PCR confirmed ZIKV infection during pregnancy. Many of these defects were is...
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ftdoajarticles:oai:doaj.org/article:205f068193a04657ba5e38b5dcd45f2f 2023-05-15T15:11:59+02:00 Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016. Anna L Funk Bruno Hoen Ingrid Vingdassalom Catherine Ryan Philippe Kadhel Kinda Schepers Stanie Gaete Benoit Tressières Arnaud Fontanet 2021-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009048 https://doaj.org/article/205f068193a04657ba5e38b5dcd45f2f EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009048 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009048 https://doaj.org/article/205f068193a04657ba5e38b5dcd45f2f PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009048 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009048 2022-12-31T15:20:16Z Background In the French Territories in the Americas (FTA), the risk of birth defects possibly associated with Zika virus (ZIKV) infection was 7.0% (95%CI: 5.0 to 9.5) among foetuses/infants of 546 women with symptomatic RT-PCR confirmed ZIKV infection during pregnancy. Many of these defects were isolated measurement-based microcephaly (i.e. without any detected brain or clinical abnormalities) or mild neurological conditions. We wanted to estimate the proportion of such minor findings among live births of women who were pregnant in the same region during the outbreak period but who were not infected with ZIKV. Methods In Guadeloupe, pregnant women were recruited at the time of delivery and tested for ZIKV infection. The outcomes of live born infants of ZIKV non-infected women were compared to those of ZIKV-exposed live born infants in Guadeloupe, extracted from the FTA prospective cohort. Results Of 490 live born infants without exposure to ZIKV, 42 infants (8.6%, 95%CI: 6.2-11.4) had mild abnormalities that have been described as 'potentially linked to ZIKV infection'; all but one of these was isolated measurement-based microcephaly. Among the 241 live born infants with ZIKV exposure, the proportion of such abnormalities, using the same definition, was similar (6.6%, 95%CI: 3.8-10.6). Conclusions Isolated anthropometric abnormalities and mild neurological conditions were as prevalent among infants with and without in-utero ZIKV exposure. If such abnormalities had not been considered as 'potentially linked to ZIKV' in the original prospective cohort in Guadeloupe, the overall estimate of the risk of birth defects considered due to the virus would have been significantly lower, at approximately 1.6% (95% CI: 0.4-4.1). Trial registration ClinicalTrials.gov (NCT02916732). Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 3 e0009048 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Anna L Funk Bruno Hoen Ingrid Vingdassalom Catherine Ryan Philippe Kadhel Kinda Schepers Stanie Gaete Benoit Tressières Arnaud Fontanet Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background In the French Territories in the Americas (FTA), the risk of birth defects possibly associated with Zika virus (ZIKV) infection was 7.0% (95%CI: 5.0 to 9.5) among foetuses/infants of 546 women with symptomatic RT-PCR confirmed ZIKV infection during pregnancy. Many of these defects were isolated measurement-based microcephaly (i.e. without any detected brain or clinical abnormalities) or mild neurological conditions. We wanted to estimate the proportion of such minor findings among live births of women who were pregnant in the same region during the outbreak period but who were not infected with ZIKV. Methods In Guadeloupe, pregnant women were recruited at the time of delivery and tested for ZIKV infection. The outcomes of live born infants of ZIKV non-infected women were compared to those of ZIKV-exposed live born infants in Guadeloupe, extracted from the FTA prospective cohort. Results Of 490 live born infants without exposure to ZIKV, 42 infants (8.6%, 95%CI: 6.2-11.4) had mild abnormalities that have been described as 'potentially linked to ZIKV infection'; all but one of these was isolated measurement-based microcephaly. Among the 241 live born infants with ZIKV exposure, the proportion of such abnormalities, using the same definition, was similar (6.6%, 95%CI: 3.8-10.6). Conclusions Isolated anthropometric abnormalities and mild neurological conditions were as prevalent among infants with and without in-utero ZIKV exposure. If such abnormalities had not been considered as 'potentially linked to ZIKV' in the original prospective cohort in Guadeloupe, the overall estimate of the risk of birth defects considered due to the virus would have been significantly lower, at approximately 1.6% (95% CI: 0.4-4.1). Trial registration ClinicalTrials.gov (NCT02916732). |
format |
Article in Journal/Newspaper |
author |
Anna L Funk Bruno Hoen Ingrid Vingdassalom Catherine Ryan Philippe Kadhel Kinda Schepers Stanie Gaete Benoit Tressières Arnaud Fontanet |
author_facet |
Anna L Funk Bruno Hoen Ingrid Vingdassalom Catherine Ryan Philippe Kadhel Kinda Schepers Stanie Gaete Benoit Tressières Arnaud Fontanet |
author_sort |
Anna L Funk |
title |
Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016. |
title_short |
Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016. |
title_full |
Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016. |
title_fullStr |
Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016. |
title_full_unstemmed |
Reassessment of the risk of birth defects due to Zika virus in Guadeloupe, 2016. |
title_sort |
reassessment of the risk of birth defects due to zika virus in guadeloupe, 2016. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009048 https://doaj.org/article/205f068193a04657ba5e38b5dcd45f2f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009048 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009048 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009048 https://doaj.org/article/205f068193a04657ba5e38b5dcd45f2f |
op_doi |
https://doi.org/10.1371/journal.pntd.0009048 |
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PLOS Neglected Tropical Diseases |
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15 |
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3 |
container_start_page |
e0009048 |
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