Bone marrow fibrosis (pseudo-myelofibrosis) in human kala-azar

• Main Authors: Rocha Filho Francisco Dário, Ferreira Francisco Valdeci de Almeida, Mendes Flávia de Oliveira, Ferreira Fernanda Nogueira Holanda, Karbage Alexandre, Alencar Marília Lage, Costa Danielle
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2000
• Subjects: Human kala-azar; Myelofibrosis; Bone marrow biopsy; Arctic medicine. Tropical medicine; RC955-962; Arctic; Azar
• Online Access: https://doaj.org/article/1f60b1ed6b494b8897160de611ac9137

Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients without detectable bone marrow fibrosis (wbmf = 18). There were no significant differences in clinical and blood parameters following treatment. All patients showed regression of hepatosplenomegaly.Our findings suggest that associated bone marrow fibrosis is transient and did not interfere in the evolution of treated patients.