The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size.
Background We previously identified via a genome wide association study variants near LEKR and CCNL1 and in the ADCY5 genes lead to lower birthweight. Here, we study the impact of these variants and social stress during pregnancy, defined as social adversity and neighborhood disparity, on infant bir...
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ftdoajarticles:oai:doaj.org/article:1f37d7a5474c49a09c92662a4142c589 2023-05-15T17:42:53+02:00 The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. Anokhi Ali Khan Alina Rodriguez Sylvain Sebert Marika Kaakinen Stéphane Cauchi Philippe Froguel Anna-Liisa Hartikainen Anneli Pouta Marjo-Riitta Järvelin 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0038216 https://doaj.org/article/1f37d7a5474c49a09c92662a4142c589 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22685556/pdf/?tool=EBI https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0038216 https://doaj.org/article/1f37d7a5474c49a09c92662a4142c589 PLoS ONE, Vol 7, Iss 6, p e38216 (2012) Medicine R Science Q article 2012 ftdoajarticles https://doi.org/10.1371/journal.pone.0038216 2022-12-31T05:03:34Z Background We previously identified via a genome wide association study variants near LEKR and CCNL1 and in the ADCY5 genes lead to lower birthweight. Here, we study the impact of these variants and social stress during pregnancy, defined as social adversity and neighborhood disparity, on infant birth size. We aimed to determine whether the addition of genetic variance magnified the observed associations. Methodology/principal findings We analyzed data from the Northern Finland Birth Cohort 1986 (n=5369). Social adversity was defined by young maternal age (<20 years), low maternal education (<11 years), and/or single marital status. Neighborhood social disparity was assessed by discrepancy between neighborhoods relative to personal socio-economic status. These variables are indicative of social and socioeconomic stress, but also of biological risk. The adjusted multiple regression analysis showed smaller birth size in both infants of mothers who experienced social adversity (birthweight by -40.4 g, 95%CI -61.4, -19.5; birth length -0.14 cm, 95%CI -0.23, -0.05; head circumference -0.09 cm 95%CI -0.15, -0.02) and neighborhood disparity (birthweight -28.8 g, 95%CI -47.7, -10.0; birth length -0.12 cm, 95%CI -0.20, -0.05). The birthweight-lowering risk allele (SNP rs900400 near LEKR and CCNL1) magnified this association in an additive manner. However, likely due to sample size restriction, this association was not significant for the SNP rs9883204 in ADCY5. Birth size difference due to social stress was greater in the presence of birthweight-lowering alleles. Conclusions/significance Social adversity, neighborhood disparity, and genetic variants have independent associations with infant birth size in the mutually adjusted analyses. If the newborn carried a risk allele rs900400 near LEKR/CCNL1, the impact of stress on birth size was stronger. These observations give support to the hypothesis that individuals with genetic or other biological risk are more vulnerable to environmental influences. Our study ... Article in Journal/Newspaper Northern Finland Directory of Open Access Journals: DOAJ Articles PLoS ONE 7 6 e38216 |
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Medicine R Science Q Anokhi Ali Khan Alina Rodriguez Sylvain Sebert Marika Kaakinen Stéphane Cauchi Philippe Froguel Anna-Liisa Hartikainen Anneli Pouta Marjo-Riitta Järvelin The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. |
topic_facet |
Medicine R Science Q |
description |
Background We previously identified via a genome wide association study variants near LEKR and CCNL1 and in the ADCY5 genes lead to lower birthweight. Here, we study the impact of these variants and social stress during pregnancy, defined as social adversity and neighborhood disparity, on infant birth size. We aimed to determine whether the addition of genetic variance magnified the observed associations. Methodology/principal findings We analyzed data from the Northern Finland Birth Cohort 1986 (n=5369). Social adversity was defined by young maternal age (<20 years), low maternal education (<11 years), and/or single marital status. Neighborhood social disparity was assessed by discrepancy between neighborhoods relative to personal socio-economic status. These variables are indicative of social and socioeconomic stress, but also of biological risk. The adjusted multiple regression analysis showed smaller birth size in both infants of mothers who experienced social adversity (birthweight by -40.4 g, 95%CI -61.4, -19.5; birth length -0.14 cm, 95%CI -0.23, -0.05; head circumference -0.09 cm 95%CI -0.15, -0.02) and neighborhood disparity (birthweight -28.8 g, 95%CI -47.7, -10.0; birth length -0.12 cm, 95%CI -0.20, -0.05). The birthweight-lowering risk allele (SNP rs900400 near LEKR and CCNL1) magnified this association in an additive manner. However, likely due to sample size restriction, this association was not significant for the SNP rs9883204 in ADCY5. Birth size difference due to social stress was greater in the presence of birthweight-lowering alleles. Conclusions/significance Social adversity, neighborhood disparity, and genetic variants have independent associations with infant birth size in the mutually adjusted analyses. If the newborn carried a risk allele rs900400 near LEKR/CCNL1, the impact of stress on birth size was stronger. These observations give support to the hypothesis that individuals with genetic or other biological risk are more vulnerable to environmental influences. Our study ... |
format |
Article in Journal/Newspaper |
author |
Anokhi Ali Khan Alina Rodriguez Sylvain Sebert Marika Kaakinen Stéphane Cauchi Philippe Froguel Anna-Liisa Hartikainen Anneli Pouta Marjo-Riitta Järvelin |
author_facet |
Anokhi Ali Khan Alina Rodriguez Sylvain Sebert Marika Kaakinen Stéphane Cauchi Philippe Froguel Anna-Liisa Hartikainen Anneli Pouta Marjo-Riitta Järvelin |
author_sort |
Anokhi Ali Khan |
title |
The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. |
title_short |
The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. |
title_full |
The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. |
title_fullStr |
The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. |
title_full_unstemmed |
The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. |
title_sort |
interplay of variants near lekr and ccnl1 and social stress in relation to birth size. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pone.0038216 https://doaj.org/article/1f37d7a5474c49a09c92662a4142c589 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
PLoS ONE, Vol 7, Iss 6, p e38216 (2012) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22685556/pdf/?tool=EBI https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0038216 https://doaj.org/article/1f37d7a5474c49a09c92662a4142c589 |
op_doi |
https://doi.org/10.1371/journal.pone.0038216 |
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PLoS ONE |
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7 |
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6 |
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