DNA methylation differences in noncoding regions in ER negative breast tumors between Black and White women

• Published in: Frontiers in Oncology
• Main Authors: Jianhong Chen, Michael J. Higgins, Qiang Hu, Thaer Khoury, Song Liu, Christine B. Ambrosone, Zhihong Gong
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media S.A. 2023
• Subjects: breast cancer; DNA methylation; noncoding regions; ER negative tumor; Black and White women; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282; Rho; DML
• Online Access: https://doi.org/10.3389/fonc.2023.1167815; https://doaj.org/article/1ee7428404bd4b3ca385a79c10e729c8

IntroductionIncidence of estrogen receptor (ER)-negative breast cancer, an aggressive tumor subtype associated with worse prognosis, is higher among African American/Black women than other US racial and ethnic groups. The reasons for this disparity remain poorly understood but may be partially expla...