Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination
Abstract Traditionally, infection with Plasmodium vivax was thought to be benign and self-limiting, however, recent evidence has demonstrated that infection with P. vivax can also result in severe illness and death. Research into P. vivax has been relatively neglected and much remains unknown regard...
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ftdoajarticles:oai:doaj.org/article:1ecc5a008ca84972b5055b151dc21579 2023-05-15T15:13:14+02:00 Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination Arnott Alicia Barry Alyssa E Reeder John C 2012-01-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-14 https://doaj.org/article/1ecc5a008ca84972b5055b151dc21579 EN eng BMC http://www.malariajournal.com/content/11/1/14 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-14 1475-2875 https://doaj.org/article/1ecc5a008ca84972b5055b151dc21579 Malaria Journal, Vol 11, Iss 1, p 14 (2012) Plasmodium vivax Malaria Population genetics Microsatellites Genetic diversity Elimination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-14 2022-12-31T08:11:14Z Abstract Traditionally, infection with Plasmodium vivax was thought to be benign and self-limiting, however, recent evidence has demonstrated that infection with P. vivax can also result in severe illness and death. Research into P. vivax has been relatively neglected and much remains unknown regarding the biology, pathogenesis and epidemiology of this parasite. One of the fundamental factors governing transmission and immunity is parasite diversity. An understanding of parasite population genetic structure is necessary to understand the epidemiology, diversity, distribution and dynamics of natural P. vivax populations. In addition, studying the population structure of genes under immune selection also enables investigation of the dynamic interplay between transmission and immunity, which is crucial for vaccine development. A lack of knowledge regarding the transmission and spread of P. vivax has been particularly highlighted in areas where malaria control and elimination programmes have made progress in reducing the burden of Plasmodium falciparum , yet P. vivax remains as a substantial obstacle. With malaria elimination back on the global agenda, mapping of global and local P. vivax population structure is essential prior to establishing goals for elimination and the roll-out of interventions. A detailed knowledge of the spatial distribution, transmission and clinical burden of P. vivax is required to act as a benchmark against which control targets can be set and measured. This paper presents an overview of what is known and what is yet to be fully understood regarding P. vivax population genetics, as well as the importance and application of P. vivax population genetics studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 14 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Plasmodium vivax Malaria Population genetics Microsatellites Genetic diversity Elimination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Plasmodium vivax Malaria Population genetics Microsatellites Genetic diversity Elimination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Arnott Alicia Barry Alyssa E Reeder John C Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination |
topic_facet |
Plasmodium vivax Malaria Population genetics Microsatellites Genetic diversity Elimination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Traditionally, infection with Plasmodium vivax was thought to be benign and self-limiting, however, recent evidence has demonstrated that infection with P. vivax can also result in severe illness and death. Research into P. vivax has been relatively neglected and much remains unknown regarding the biology, pathogenesis and epidemiology of this parasite. One of the fundamental factors governing transmission and immunity is parasite diversity. An understanding of parasite population genetic structure is necessary to understand the epidemiology, diversity, distribution and dynamics of natural P. vivax populations. In addition, studying the population structure of genes under immune selection also enables investigation of the dynamic interplay between transmission and immunity, which is crucial for vaccine development. A lack of knowledge regarding the transmission and spread of P. vivax has been particularly highlighted in areas where malaria control and elimination programmes have made progress in reducing the burden of Plasmodium falciparum , yet P. vivax remains as a substantial obstacle. With malaria elimination back on the global agenda, mapping of global and local P. vivax population structure is essential prior to establishing goals for elimination and the roll-out of interventions. A detailed knowledge of the spatial distribution, transmission and clinical burden of P. vivax is required to act as a benchmark against which control targets can be set and measured. This paper presents an overview of what is known and what is yet to be fully understood regarding P. vivax population genetics, as well as the importance and application of P. vivax population genetics studies. |
format |
Article in Journal/Newspaper |
author |
Arnott Alicia Barry Alyssa E Reeder John C |
author_facet |
Arnott Alicia Barry Alyssa E Reeder John C |
author_sort |
Arnott Alicia |
title |
Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination |
title_short |
Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination |
title_full |
Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination |
title_fullStr |
Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination |
title_full_unstemmed |
Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination |
title_sort |
understanding the population genetics of plasmodium vivax is essential for malaria control and elimination |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-14 https://doaj.org/article/1ecc5a008ca84972b5055b151dc21579 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 14 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/14 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-14 1475-2875 https://doaj.org/article/1ecc5a008ca84972b5055b151dc21579 |
op_doi |
https://doi.org/10.1186/1475-2875-11-14 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
container_start_page |
14 |
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1766343819776753664 |