Rheopathologic Consequence of Plasmodium vivax Rosette Formation.
Malaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance. This study highlights correlation between rosette formati...
Published in: | PLOS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:1ebef097d4e74182bc640fbc8ddd383f 2023-05-15T15:00:06+02:00 Rheopathologic Consequence of Plasmodium vivax Rosette Formation. Rou Zhang Wenn-Chyau Lee Yee-Ling Lau Letusa Albrecht Stefanie C P Lopes Fabio T M Costa Rossarin Suwanarusk Francois Nosten Brian M Cooke Laurent Rénia Bruce Russell 2016-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004912 https://doaj.org/article/1ebef097d4e74182bc640fbc8ddd383f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4980013?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004912 https://doaj.org/article/1ebef097d4e74182bc640fbc8ddd383f PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004912 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004912 2022-12-30T20:49:46Z Malaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance. This study highlights correlation between rosette formation and altered membrane deformability of P. vivax-infected erythrocytes, where the rosette-forming infected erythrocytes are significantly more rigid than their non-rosetting counterparts. The adhesion of normocytes to the PvIRBC is strong (mean binding force of 440pN) resulting in stable rosette formation even under high physiological shear flow stress. Rosetting may contribute to the sequestration of PvIRBC schizonts in the host microvasculature or spleen. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 8 e0004912 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rou Zhang Wenn-Chyau Lee Yee-Ling Lau Letusa Albrecht Stefanie C P Lopes Fabio T M Costa Rossarin Suwanarusk Francois Nosten Brian M Cooke Laurent Rénia Bruce Russell Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Malaria parasites dramatically alter the rheological properties of infected red blood cells. In the case of Plasmodium vivax, the parasite rapidly decreases the shear elastic modulus of the invaded RBC, enabling it to avoid splenic clearance. This study highlights correlation between rosette formation and altered membrane deformability of P. vivax-infected erythrocytes, where the rosette-forming infected erythrocytes are significantly more rigid than their non-rosetting counterparts. The adhesion of normocytes to the PvIRBC is strong (mean binding force of 440pN) resulting in stable rosette formation even under high physiological shear flow stress. Rosetting may contribute to the sequestration of PvIRBC schizonts in the host microvasculature or spleen. |
format |
Article in Journal/Newspaper |
author |
Rou Zhang Wenn-Chyau Lee Yee-Ling Lau Letusa Albrecht Stefanie C P Lopes Fabio T M Costa Rossarin Suwanarusk Francois Nosten Brian M Cooke Laurent Rénia Bruce Russell |
author_facet |
Rou Zhang Wenn-Chyau Lee Yee-Ling Lau Letusa Albrecht Stefanie C P Lopes Fabio T M Costa Rossarin Suwanarusk Francois Nosten Brian M Cooke Laurent Rénia Bruce Russell |
author_sort |
Rou Zhang |
title |
Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
title_short |
Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
title_full |
Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
title_fullStr |
Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
title_full_unstemmed |
Rheopathologic Consequence of Plasmodium vivax Rosette Formation. |
title_sort |
rheopathologic consequence of plasmodium vivax rosette formation. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004912 https://doaj.org/article/1ebef097d4e74182bc640fbc8ddd383f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004912 (2016) |
op_relation |
http://europepmc.org/articles/PMC4980013?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004912 https://doaj.org/article/1ebef097d4e74182bc640fbc8ddd383f |
op_doi |
https://doi.org/10.1371/journal.pntd.0004912 |
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PLOS Neglected Tropical Diseases |
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10 |
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8 |
container_start_page |
e0004912 |
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