Prophylactic platelets in dengue: survey responses highlight lack of an evidence base.
Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage. As a re...
Published in: | PLoS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:1e838eee702240d58e255c6606e04ce0 2023-05-15T15:05:11+02:00 Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. James Whitehorn Rosmari Rodriguez Roche Maria G Guzman Eric Martinez Wilmar Villamil Gomez Leonard Nainggolan Ida Safitri Laksono Ajay Mishra Lucy Lum Abul Faiz Amadou Sall Joshua Dawurung Alvaro Borges Yee-Sin Leo Lucille Blumberg Daniel G Bausch Axel Kroeger Olaf Horstick Guy Thwaites Heiman Wertheim Mattias Larsson Tran Tinh Hien Rosanna Peeling Bridget Wills Cameron Simmons Jeremy Farrar 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001716 https://doaj.org/article/1e838eee702240d58e255c6606e04ce0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3383756?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001716 https://doaj.org/article/1e838eee702240d58e255c6606e04ce0 PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1716 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001716 2022-12-30T23:59:23Z Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage. As a result of this prophylactic platelet transfusions are sometimes advocated for the prevention of haemorrhage. There is currently no evidence to support this practice, and platelet transfusions are costly and sometimes harmful. We conducted a global survey to assess the different approaches to the use of platelets in dengue. Respondents were all physicians involved with the treatment of patients with dengue. Respondents were asked that their answers reflected what they would do if they were the treating physician. We received responses from 306 physicians from 20 different countries. The heterogeneity of the responses highlights the variation in clinical practice and lack of an evidence base in this area and underscores the importance of prospective clinical trials to address this key question in the clinical management of patients with dengue. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 6 e1716 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 James Whitehorn Rosmari Rodriguez Roche Maria G Guzman Eric Martinez Wilmar Villamil Gomez Leonard Nainggolan Ida Safitri Laksono Ajay Mishra Lucy Lum Abul Faiz Amadou Sall Joshua Dawurung Alvaro Borges Yee-Sin Leo Lucille Blumberg Daniel G Bausch Axel Kroeger Olaf Horstick Guy Thwaites Heiman Wertheim Mattias Larsson Tran Tinh Hien Rosanna Peeling Bridget Wills Cameron Simmons Jeremy Farrar Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage. As a result of this prophylactic platelet transfusions are sometimes advocated for the prevention of haemorrhage. There is currently no evidence to support this practice, and platelet transfusions are costly and sometimes harmful. We conducted a global survey to assess the different approaches to the use of platelets in dengue. Respondents were all physicians involved with the treatment of patients with dengue. Respondents were asked that their answers reflected what they would do if they were the treating physician. We received responses from 306 physicians from 20 different countries. The heterogeneity of the responses highlights the variation in clinical practice and lack of an evidence base in this area and underscores the importance of prospective clinical trials to address this key question in the clinical management of patients with dengue. |
format |
Article in Journal/Newspaper |
author |
James Whitehorn Rosmari Rodriguez Roche Maria G Guzman Eric Martinez Wilmar Villamil Gomez Leonard Nainggolan Ida Safitri Laksono Ajay Mishra Lucy Lum Abul Faiz Amadou Sall Joshua Dawurung Alvaro Borges Yee-Sin Leo Lucille Blumberg Daniel G Bausch Axel Kroeger Olaf Horstick Guy Thwaites Heiman Wertheim Mattias Larsson Tran Tinh Hien Rosanna Peeling Bridget Wills Cameron Simmons Jeremy Farrar |
author_facet |
James Whitehorn Rosmari Rodriguez Roche Maria G Guzman Eric Martinez Wilmar Villamil Gomez Leonard Nainggolan Ida Safitri Laksono Ajay Mishra Lucy Lum Abul Faiz Amadou Sall Joshua Dawurung Alvaro Borges Yee-Sin Leo Lucille Blumberg Daniel G Bausch Axel Kroeger Olaf Horstick Guy Thwaites Heiman Wertheim Mattias Larsson Tran Tinh Hien Rosanna Peeling Bridget Wills Cameron Simmons Jeremy Farrar |
author_sort |
James Whitehorn |
title |
Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. |
title_short |
Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. |
title_full |
Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. |
title_fullStr |
Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. |
title_full_unstemmed |
Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. |
title_sort |
prophylactic platelets in dengue: survey responses highlight lack of an evidence base. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001716 https://doaj.org/article/1e838eee702240d58e255c6606e04ce0 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1716 (2012) |
op_relation |
http://europepmc.org/articles/PMC3383756?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001716 https://doaj.org/article/1e838eee702240d58e255c6606e04ce0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001716 |
container_title |
PLoS Neglected Tropical Diseases |
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6 |
container_issue |
6 |
container_start_page |
e1716 |
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1766336935090978816 |