ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C
The determination of aminotranferases levels is very useful in the diagnosis of hepatopathies. In recent years, an elevated serum ALT level in blood donors has been associated with an increased risk of post-transfusion hepatitis (PTH). The purpose of the study was to research the factors associated...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1998
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Online Access: | https://doi.org/10.1590/S0036-46651998000400003 https://doaj.org/article/1e7e8d63531b465dbc7f3e265b9a04c7 |
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ftdoajarticles:oai:doaj.org/article:1e7e8d63531b465dbc7f3e265b9a04c7 2024-09-09T19:28:24+00:00 ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C Fernando Lopes GONÇALES Jr. Raquel Silveira Bello STUCCHI Priscila Maria Oliveira PAPAIORDANOU Maria Helena Postal PAVAN Neiva Sellan Lopes GONÇALES João Renato Rebello PINHO 1998-07-01T00:00:00Z https://doi.org/10.1590/S0036-46651998000400003 https://doaj.org/article/1e7e8d63531b465dbc7f3e265b9a04c7 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000400003 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651998000400003 0036-4665 1678-9946 https://doaj.org/article/1e7e8d63531b465dbc7f3e265b9a04c7 Revista do Instituto de Medicina Tropical de São Paulo, Vol 40, Iss 4, Pp -224 (1998) Blood donors ALT Pos transfusion hepatitis anti-HCV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1998 ftdoajarticles https://doi.org/10.1590/S0036-46651998000400003 2024-08-05T17:49:31Z The determination of aminotranferases levels is very useful in the diagnosis of hepatopathies. In recent years, an elevated serum ALT level in blood donors has been associated with an increased risk of post-transfusion hepatitis (PTH). The purpose of the study was to research the factors associated with elevated ALT levels in a cohort of voluntary blood donors and to evaluate the relationship between increased ALT levels and the development of hepatitis C (HCV) infection. 166 volunteer blood donors with elevated ALT at the time of their first donation were studied. All of the donors were questioned about previous hepatopathies, exposure to hepatitis, exposure to chemicals, use of medication or drugs, sexual behaviour, contact with blood or secretions and their intake of alcohol. Every three months, the serum levels of AST, ALT, alkaline phosphatase, gamma glutamyl transpeptidase, cholesterol, triglyceride and glycemia are assessed over a two year follow-up. The serum thyroid hormone levels as well as the presence of auto-antibodies were also measured. Abdominal ultrasound was performed in all patients with persistently elevated ALT or AST levels. A needle biopsy of liver was performed in 9 donors without definite diagnostic after medical investigation. The presence of anti-HCV antibodies in 116 donors were assayed again the first clinical evaluation. At the end of follow-up period (2 years later) 71 donors were tested again for the presence of anti-HCV antibodies. None of donors resulted positive for hepatitis B or hepatitis C markers during the follow-up. Of the 116 donors, 101 (87%) had persistently elevated ALT serum levels during the follow-up. Obesity and alcoholism were the principal conditions related to elevated ALT serum levels in 91/101 (90.1%) donors. Hypertriglyceridemia, hypercholesterolemia, hypothyroidism and diabetes mellitus also were associated with increased ALT levels. Only 1/101 (0.9%) had mild chronic active non A-G viral hepatitis and 3/101 (2.9%) had liver biopsy with non-specific ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 40 4 219 224 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Blood donors ALT Pos transfusion hepatitis anti-HCV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Blood donors ALT Pos transfusion hepatitis anti-HCV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Fernando Lopes GONÇALES Jr. Raquel Silveira Bello STUCCHI Priscila Maria Oliveira PAPAIORDANOU Maria Helena Postal PAVAN Neiva Sellan Lopes GONÇALES João Renato Rebello PINHO ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C |
topic_facet |
Blood donors ALT Pos transfusion hepatitis anti-HCV Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
The determination of aminotranferases levels is very useful in the diagnosis of hepatopathies. In recent years, an elevated serum ALT level in blood donors has been associated with an increased risk of post-transfusion hepatitis (PTH). The purpose of the study was to research the factors associated with elevated ALT levels in a cohort of voluntary blood donors and to evaluate the relationship between increased ALT levels and the development of hepatitis C (HCV) infection. 166 volunteer blood donors with elevated ALT at the time of their first donation were studied. All of the donors were questioned about previous hepatopathies, exposure to hepatitis, exposure to chemicals, use of medication or drugs, sexual behaviour, contact with blood or secretions and their intake of alcohol. Every three months, the serum levels of AST, ALT, alkaline phosphatase, gamma glutamyl transpeptidase, cholesterol, triglyceride and glycemia are assessed over a two year follow-up. The serum thyroid hormone levels as well as the presence of auto-antibodies were also measured. Abdominal ultrasound was performed in all patients with persistently elevated ALT or AST levels. A needle biopsy of liver was performed in 9 donors without definite diagnostic after medical investigation. The presence of anti-HCV antibodies in 116 donors were assayed again the first clinical evaluation. At the end of follow-up period (2 years later) 71 donors were tested again for the presence of anti-HCV antibodies. None of donors resulted positive for hepatitis B or hepatitis C markers during the follow-up. Of the 116 donors, 101 (87%) had persistently elevated ALT serum levels during the follow-up. Obesity and alcoholism were the principal conditions related to elevated ALT serum levels in 91/101 (90.1%) donors. Hypertriglyceridemia, hypercholesterolemia, hypothyroidism and diabetes mellitus also were associated with increased ALT levels. Only 1/101 (0.9%) had mild chronic active non A-G viral hepatitis and 3/101 (2.9%) had liver biopsy with non-specific ... |
format |
Article in Journal/Newspaper |
author |
Fernando Lopes GONÇALES Jr. Raquel Silveira Bello STUCCHI Priscila Maria Oliveira PAPAIORDANOU Maria Helena Postal PAVAN Neiva Sellan Lopes GONÇALES João Renato Rebello PINHO |
author_facet |
Fernando Lopes GONÇALES Jr. Raquel Silveira Bello STUCCHI Priscila Maria Oliveira PAPAIORDANOU Maria Helena Postal PAVAN Neiva Sellan Lopes GONÇALES João Renato Rebello PINHO |
author_sort |
Fernando Lopes GONÇALES Jr. |
title |
ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C |
title_short |
ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C |
title_full |
ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C |
title_fullStr |
ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C |
title_full_unstemmed |
ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C |
title_sort |
elevated alanine aminotransferase (alt) in blood donors: an assessment of the main associated conditions and its relationship to the development of hepatitis c |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1998 |
url |
https://doi.org/10.1590/S0036-46651998000400003 https://doaj.org/article/1e7e8d63531b465dbc7f3e265b9a04c7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 40, Iss 4, Pp -224 (1998) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000400003 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651998000400003 0036-4665 1678-9946 https://doaj.org/article/1e7e8d63531b465dbc7f3e265b9a04c7 |
op_doi |
https://doi.org/10.1590/S0036-46651998000400003 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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40 |
container_issue |
4 |
container_start_page |
219 |
op_container_end_page |
224 |
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