Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice
Objective: To evaluate the effect of Alpinia officinarum Hance (A. officinarum) extract on lung injury caused by particulate matter (PM). Methods: The Kunming mice were intranasally instilled with PM and treated with A. officinarum extract for 3 weeks. Bronchoalveolar lavage fluid, blood and lung sa...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:1e783bc4c66340b292caad5caa078349 2023-05-15T15:09:07+02:00 Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice Yao-xin Zhao Wen-jing Ruan Wen-lai Xue Ling Zhao 2019-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.272487 https://doaj.org/article/1e783bc4c66340b292caad5caa078349 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=12;spage=565;epage=573;aulast=Zhao https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.272487 https://doaj.org/article/1e783bc4c66340b292caad5caa078349 Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 12, Pp 565-573 (2019) alpinia offcinarum hance extract particulate matter lung injury Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.4103/1995-7645.272487 2022-12-31T13:32:52Z Objective: To evaluate the effect of Alpinia officinarum Hance (A. officinarum) extract on lung injury caused by particulate matter (PM). Methods: The Kunming mice were intranasally instilled with PM and treated with A. officinarum extract for 3 weeks. Bronchoalveolar lavage fluid, blood and lung samples were collected for biochemical, serological and histopathological studies. Results: Serological analysis showed that albumin levels, lactate dehydrogenase and alkaline phosphatase activities in bronchoalveolar lavage fluid were significantly reduced after administrations of 50, 100 and 200 mg/kg of A. officinarum extracts to the PM injured mice. Markers of oxidative stress, nitric oxide, malondialdehyde levels and nitric oxide synthase activities, were significantly decreased. Correspondingly, total superoxide dismutase activity was improved dramatically. The expressions of interleukin-6 and tumor necrosis factor alpha were also down-regulated obviously. In addition, pathological sections of lung tissue showed that A. officinarum could reduce the infiltration of inflammatory cells, pulmonary edema and pulmonary fibrosis. These results showed that A. officinarum extract could alleviate PM-induced lung injury via reducing the permeability of cell membranes in lung tissue, eliminating oxidative stress and relieving inflammatory response. Conclusions: A. officinarum extract was an efficient treatment for PM-induced lung injury ir mice, and it may be a promising therapeutic agent in future. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 12 12 565 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
alpinia offcinarum hance extract particulate matter lung injury Arctic medicine. Tropical medicine RC955-962 |
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alpinia offcinarum hance extract particulate matter lung injury Arctic medicine. Tropical medicine RC955-962 Yao-xin Zhao Wen-jing Ruan Wen-lai Xue Ling Zhao Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice |
topic_facet |
alpinia offcinarum hance extract particulate matter lung injury Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate the effect of Alpinia officinarum Hance (A. officinarum) extract on lung injury caused by particulate matter (PM). Methods: The Kunming mice were intranasally instilled with PM and treated with A. officinarum extract for 3 weeks. Bronchoalveolar lavage fluid, blood and lung samples were collected for biochemical, serological and histopathological studies. Results: Serological analysis showed that albumin levels, lactate dehydrogenase and alkaline phosphatase activities in bronchoalveolar lavage fluid were significantly reduced after administrations of 50, 100 and 200 mg/kg of A. officinarum extracts to the PM injured mice. Markers of oxidative stress, nitric oxide, malondialdehyde levels and nitric oxide synthase activities, were significantly decreased. Correspondingly, total superoxide dismutase activity was improved dramatically. The expressions of interleukin-6 and tumor necrosis factor alpha were also down-regulated obviously. In addition, pathological sections of lung tissue showed that A. officinarum could reduce the infiltration of inflammatory cells, pulmonary edema and pulmonary fibrosis. These results showed that A. officinarum extract could alleviate PM-induced lung injury via reducing the permeability of cell membranes in lung tissue, eliminating oxidative stress and relieving inflammatory response. Conclusions: A. officinarum extract was an efficient treatment for PM-induced lung injury ir mice, and it may be a promising therapeutic agent in future. |
format |
Article in Journal/Newspaper |
author |
Yao-xin Zhao Wen-jing Ruan Wen-lai Xue Ling Zhao |
author_facet |
Yao-xin Zhao Wen-jing Ruan Wen-lai Xue Ling Zhao |
author_sort |
Yao-xin Zhao |
title |
Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice |
title_short |
Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice |
title_full |
Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice |
title_fullStr |
Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice |
title_full_unstemmed |
Alpinia officinarum Hance extract alleviates particulate matter-induced lung injury in mice |
title_sort |
alpinia officinarum hance extract alleviates particulate matter-induced lung injury in mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/1995-7645.272487 https://doaj.org/article/1e783bc4c66340b292caad5caa078349 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 12, Pp 565-573 (2019) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=12;spage=565;epage=573;aulast=Zhao https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.272487 https://doaj.org/article/1e783bc4c66340b292caad5caa078349 |
op_doi |
https://doi.org/10.4103/1995-7645.272487 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
12 |
container_issue |
12 |
container_start_page |
565 |
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1766340349128605696 |