Platelet count and risk of major bleeding in venous thromboembolism
The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear. We therefore investigated the association between platelet count, measured at VTE diagnosis and before the thrombotic event, and risk of major blee...
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2021
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ftdoajarticles:oai:doaj.org/article:1e603a0226ba44f3a2ac2c295e35ce58 2023-10-09T21:56:18+02:00 Platelet count and risk of major bleeding in venous thromboembolism Håkon S. Johnsen Sigrid K. Braekkan Vânia M. Morelli John-Bjarne Hansen 2021-05-01T00:00:00Z https://doi.org/10.1080/09537104.2020.1769052 https://doaj.org/article/1e603a0226ba44f3a2ac2c295e35ce58 EN eng Taylor & Francis Group http://dx.doi.org/10.1080/09537104.2020.1769052 https://doaj.org/toc/0953-7104 https://doaj.org/toc/1369-1635 0953-7104 1369-1635 doi:10.1080/09537104.2020.1769052 https://doaj.org/article/1e603a0226ba44f3a2ac2c295e35ce58 Platelets, Vol 32, Iss 4, Pp 444-452 (2021) anticoagulation hemorrhage bleeding platelet count venous thromboembolism Diseases of the blood and blood-forming organs RC633-647.5 article 2021 ftdoajarticles https://doi.org/10.1080/09537104.2020.1769052 2023-09-17T00:35:01Z The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear. We therefore investigated the association between platelet count, measured at VTE diagnosis and before the thrombotic event, and risk of major bleeding. Participants comprised 744 patients with incident VTE derived from the Tromsø Study. Major bleedings were recorded during the first year after VTE. Cox-regression was used to calculate hazard ratios (HRs) for major bleeding across platelet count quartiles. There were 55 major bleedings (incidence rate 9.1/100 person-years, 95% confidence interval [CI] 7.0–11.8). The major bleeding risk increased across quartiles of platelet count measured at VTE diagnosis (P for trend<0.02). In the age- and sex-adjusted model, subjects with platelet count in the highest quartile (≥300x109/L) had a 4.3-fold (95% CI 1.7–10.9) higher risk of major bleeding compared to those with platelet count in the lowest quartile (≤192x109/L), and exclusion of patients with cancer yielded similar results. When platelet count was measured on average 7 years before a VTE, the corresponding HR was 2.5 (95% CI 0.9–6.7). Our results suggest that increasing platelet count, assessed several years before and at VTE diagnosis, is associated with a higher risk of major bleeding, and could be a stable individual marker of major bleeding risk in VTE-patients. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Tromsø Platelets 32 4 444 452 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
anticoagulation hemorrhage bleeding platelet count venous thromboembolism Diseases of the blood and blood-forming organs RC633-647.5 |
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anticoagulation hemorrhage bleeding platelet count venous thromboembolism Diseases of the blood and blood-forming organs RC633-647.5 Håkon S. Johnsen Sigrid K. Braekkan Vânia M. Morelli John-Bjarne Hansen Platelet count and risk of major bleeding in venous thromboembolism |
topic_facet |
anticoagulation hemorrhage bleeding platelet count venous thromboembolism Diseases of the blood and blood-forming organs RC633-647.5 |
description |
The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear. We therefore investigated the association between platelet count, measured at VTE diagnosis and before the thrombotic event, and risk of major bleeding. Participants comprised 744 patients with incident VTE derived from the Tromsø Study. Major bleedings were recorded during the first year after VTE. Cox-regression was used to calculate hazard ratios (HRs) for major bleeding across platelet count quartiles. There were 55 major bleedings (incidence rate 9.1/100 person-years, 95% confidence interval [CI] 7.0–11.8). The major bleeding risk increased across quartiles of platelet count measured at VTE diagnosis (P for trend<0.02). In the age- and sex-adjusted model, subjects with platelet count in the highest quartile (≥300x109/L) had a 4.3-fold (95% CI 1.7–10.9) higher risk of major bleeding compared to those with platelet count in the lowest quartile (≤192x109/L), and exclusion of patients with cancer yielded similar results. When platelet count was measured on average 7 years before a VTE, the corresponding HR was 2.5 (95% CI 0.9–6.7). Our results suggest that increasing platelet count, assessed several years before and at VTE diagnosis, is associated with a higher risk of major bleeding, and could be a stable individual marker of major bleeding risk in VTE-patients. |
format |
Article in Journal/Newspaper |
author |
Håkon S. Johnsen Sigrid K. Braekkan Vânia M. Morelli John-Bjarne Hansen |
author_facet |
Håkon S. Johnsen Sigrid K. Braekkan Vânia M. Morelli John-Bjarne Hansen |
author_sort |
Håkon S. Johnsen |
title |
Platelet count and risk of major bleeding in venous thromboembolism |
title_short |
Platelet count and risk of major bleeding in venous thromboembolism |
title_full |
Platelet count and risk of major bleeding in venous thromboembolism |
title_fullStr |
Platelet count and risk of major bleeding in venous thromboembolism |
title_full_unstemmed |
Platelet count and risk of major bleeding in venous thromboembolism |
title_sort |
platelet count and risk of major bleeding in venous thromboembolism |
publisher |
Taylor & Francis Group |
publishDate |
2021 |
url |
https://doi.org/10.1080/09537104.2020.1769052 https://doaj.org/article/1e603a0226ba44f3a2ac2c295e35ce58 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Platelets, Vol 32, Iss 4, Pp 444-452 (2021) |
op_relation |
http://dx.doi.org/10.1080/09537104.2020.1769052 https://doaj.org/toc/0953-7104 https://doaj.org/toc/1369-1635 0953-7104 1369-1635 doi:10.1080/09537104.2020.1769052 https://doaj.org/article/1e603a0226ba44f3a2ac2c295e35ce58 |
op_doi |
https://doi.org/10.1080/09537104.2020.1769052 |
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Platelets |
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32 |
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4 |
container_start_page |
444 |
op_container_end_page |
452 |
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