Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico.
An estimated 2 million inhabitants are infected with Chagas disease in Mexico, with highest prevalence coinciding with highest demographic density in the southern half of the country. After vector-borne transmission, Trypanosoma cruzi is principally transmitted to humans via blood transfusion. Despi...
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ftdoajarticles:oai:doaj.org/article:1de0feb48b59480d941db31ef8c25ba3 2023-05-15T15:16:53+02:00 Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico. Gilberto Sánchez-González Alejandro Figueroa-Lara Miguel Elizondo-Cano Leslie Wilson Barbara Novelo-Garza Leopoldo Valiente-Banuet Janine M Ramsey 2016-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004528 https://doaj.org/article/1de0feb48b59480d941db31ef8c25ba3 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4803194?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004528 https://doaj.org/article/1de0feb48b59480d941db31ef8c25ba3 PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004528 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004528 2022-12-31T14:03:43Z An estimated 2 million inhabitants are infected with Chagas disease in Mexico, with highest prevalence coinciding with highest demographic density in the southern half of the country. After vector-borne transmission, Trypanosoma cruzi is principally transmitted to humans via blood transfusion. Despite initiation of serological screening of blood donations or donors for T. cruzi since 1990 in most Latin American countries, Mexico only finally included mandatory serological screening nationwide in official Norms in 2012. Most recent regulatory changes and segmented blood services in Mexico may affect compliance of mandatory screening guidelines. The objective of this study was to calculate the incremental cost-effectiveness ratio for total compliance of current guidelines from both Mexican primary healthcare and regular salaried worker health service institutions: the Secretary of Health and the Mexican Institute for Social Security. We developed a bi-modular model to analyze compliance using a decision tree for the most common screening algorithms for each health institution, and a Markov transition model for the natural history of illness and care. The incremental cost effectiveness ratio based on life-years gained is US$ 383 for the Secretary of Health, while the cost for an additional life-year gained is US$ 463 for the Social Security Institute. The results of the present study suggest that due to incomplete compliance of Mexico's national legislation during 2013 and 2014, the MoH has failed to confirm 15,162 T. cruzi infections, has not prevented 2,347 avoidable infections, and has lost 333,483 life-years. Although there is a vast difference in T. cruzi prevalence between Bolivia and Mexico, Bolivia established mandatory blood screening for T.cruzi in 1996 and until 2002 detected and discarded 11,489 T. cruzi -infected blood units and prevented 2,879 potential infections with their transfusion blood screening program. In the first two years of Mexico's mandated program, the two primary institutions failed to ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 3 e0004528 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gilberto Sánchez-González Alejandro Figueroa-Lara Miguel Elizondo-Cano Leslie Wilson Barbara Novelo-Garza Leopoldo Valiente-Banuet Janine M Ramsey Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
An estimated 2 million inhabitants are infected with Chagas disease in Mexico, with highest prevalence coinciding with highest demographic density in the southern half of the country. After vector-borne transmission, Trypanosoma cruzi is principally transmitted to humans via blood transfusion. Despite initiation of serological screening of blood donations or donors for T. cruzi since 1990 in most Latin American countries, Mexico only finally included mandatory serological screening nationwide in official Norms in 2012. Most recent regulatory changes and segmented blood services in Mexico may affect compliance of mandatory screening guidelines. The objective of this study was to calculate the incremental cost-effectiveness ratio for total compliance of current guidelines from both Mexican primary healthcare and regular salaried worker health service institutions: the Secretary of Health and the Mexican Institute for Social Security. We developed a bi-modular model to analyze compliance using a decision tree for the most common screening algorithms for each health institution, and a Markov transition model for the natural history of illness and care. The incremental cost effectiveness ratio based on life-years gained is US$ 383 for the Secretary of Health, while the cost for an additional life-year gained is US$ 463 for the Social Security Institute. The results of the present study suggest that due to incomplete compliance of Mexico's national legislation during 2013 and 2014, the MoH has failed to confirm 15,162 T. cruzi infections, has not prevented 2,347 avoidable infections, and has lost 333,483 life-years. Although there is a vast difference in T. cruzi prevalence between Bolivia and Mexico, Bolivia established mandatory blood screening for T.cruzi in 1996 and until 2002 detected and discarded 11,489 T. cruzi -infected blood units and prevented 2,879 potential infections with their transfusion blood screening program. In the first two years of Mexico's mandated program, the two primary institutions failed to ... |
format |
Article in Journal/Newspaper |
author |
Gilberto Sánchez-González Alejandro Figueroa-Lara Miguel Elizondo-Cano Leslie Wilson Barbara Novelo-Garza Leopoldo Valiente-Banuet Janine M Ramsey |
author_facet |
Gilberto Sánchez-González Alejandro Figueroa-Lara Miguel Elizondo-Cano Leslie Wilson Barbara Novelo-Garza Leopoldo Valiente-Banuet Janine M Ramsey |
author_sort |
Gilberto Sánchez-González |
title |
Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico. |
title_short |
Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico. |
title_full |
Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico. |
title_fullStr |
Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico. |
title_full_unstemmed |
Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico. |
title_sort |
cost-effectiveness of blood donation screening for trypanosoma cruzi in mexico. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004528 https://doaj.org/article/1de0feb48b59480d941db31ef8c25ba3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004528 (2016) |
op_relation |
http://europepmc.org/articles/PMC4803194?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004528 https://doaj.org/article/1de0feb48b59480d941db31ef8c25ba3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004528 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
3 |
container_start_page |
e0004528 |
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1766347178106683392 |