The Host Genetic Diversity in Malaria Infection
Populations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease. The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations ass...
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ftdoajarticles:oai:doaj.org/article:1dd88a2cd8904dfb83621c9da89e64b0 2024-09-09T19:25:13+00:00 The Host Genetic Diversity in Malaria Infection Vitor R. R. de Mendonça Marilda Souza Goncalves Manoel Barral-Netto 2012-01-01T00:00:00Z https://doi.org/10.1155/2012/940616 https://doaj.org/article/1dd88a2cd8904dfb83621c9da89e64b0 EN eng Wiley http://dx.doi.org/10.1155/2012/940616 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/940616 https://doaj.org/article/1dd88a2cd8904dfb83621c9da89e64b0 Journal of Tropical Medicine, Vol 2012 (2012) Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1155/2012/940616 2024-08-05T17:48:36Z Populations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease. The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations associated with erythrocytes or mediators of the immune system, which might influence malaria outcome. Moreover, polymorphisms in genes related to molecules involved in mechanisms of cytoadherence and their influence on malaria pathology are also discussed. The results of some studies have suggested that the combinatorial effects of a set of genetic factors in the erythrocyte-immunology pathway might be relevant to host resistance or susceptibility against Plasmodium infection. However, these results must be interpreted with caution because of the differences observed in the functionality and frequency of polymorphisms within different populations. With the recent advances in molecular biology techniques, more robust studies with reliable data have been reported, and the results of these studies have identified individual genetic factors for consideration in preventing severe disease and the individual response to treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2012 1 17 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Vitor R. R. de Mendonça Marilda Souza Goncalves Manoel Barral-Netto The Host Genetic Diversity in Malaria Infection |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Populations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease. The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations associated with erythrocytes or mediators of the immune system, which might influence malaria outcome. Moreover, polymorphisms in genes related to molecules involved in mechanisms of cytoadherence and their influence on malaria pathology are also discussed. The results of some studies have suggested that the combinatorial effects of a set of genetic factors in the erythrocyte-immunology pathway might be relevant to host resistance or susceptibility against Plasmodium infection. However, these results must be interpreted with caution because of the differences observed in the functionality and frequency of polymorphisms within different populations. With the recent advances in molecular biology techniques, more robust studies with reliable data have been reported, and the results of these studies have identified individual genetic factors for consideration in preventing severe disease and the individual response to treatment. |
format |
Article in Journal/Newspaper |
author |
Vitor R. R. de Mendonça Marilda Souza Goncalves Manoel Barral-Netto |
author_facet |
Vitor R. R. de Mendonça Marilda Souza Goncalves Manoel Barral-Netto |
author_sort |
Vitor R. R. de Mendonça |
title |
The Host Genetic Diversity in Malaria Infection |
title_short |
The Host Genetic Diversity in Malaria Infection |
title_full |
The Host Genetic Diversity in Malaria Infection |
title_fullStr |
The Host Genetic Diversity in Malaria Infection |
title_full_unstemmed |
The Host Genetic Diversity in Malaria Infection |
title_sort |
host genetic diversity in malaria infection |
publisher |
Wiley |
publishDate |
2012 |
url |
https://doi.org/10.1155/2012/940616 https://doaj.org/article/1dd88a2cd8904dfb83621c9da89e64b0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2012 (2012) |
op_relation |
http://dx.doi.org/10.1155/2012/940616 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/940616 https://doaj.org/article/1dd88a2cd8904dfb83621c9da89e64b0 |
op_doi |
https://doi.org/10.1155/2012/940616 |
container_title |
Journal of Tropical Medicine |
container_volume |
2012 |
container_start_page |
1 |
op_container_end_page |
17 |
_version_ |
1809894978146533376 |