Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection.
Schistosomiasis remains a significant health burden in many areas of the world. Morbidity control, focused on limiting infection intensity through periodic delivery of anti-schistosomal medicines, is the thrust of current World Health Organization guidelines (2006) for reduction of Schistosoma-relat...
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ftdoajarticles:oai:doaj.org/article:1db03e0a493a4903a4cdf20fdb388dc8 2023-05-15T15:16:29+02:00 Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection. Xiaoxia Wang David Gurarie Peter L Mungai Eric M Muchiri Uriel Kitron Charles H King 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001903 https://doaj.org/article/1db03e0a493a4903a4cdf20fdb388dc8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3499404?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001903 https://doaj.org/article/1db03e0a493a4903a4cdf20fdb388dc8 PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1903 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001903 2022-12-30T21:58:07Z Schistosomiasis remains a significant health burden in many areas of the world. Morbidity control, focused on limiting infection intensity through periodic delivery of anti-schistosomal medicines, is the thrust of current World Health Organization guidelines (2006) for reduction of Schistosoma-related disease. A new appreciation of the lifetime impact of repeated Schistosoma infection has directed attention toward strategies for greater suppression of parasite infection per se, with the goal of transmission interruption. Variations in drug schedules involving increased population coverage and/or treatment frequency are now undergoing field trials. However, their relative effectiveness in long-term infection suppression is presently unknown.Our study used available field data to calibrate advanced network models of village-level Schistosoma transmission to project outcomes of six different community- or school age-based programs, as compared to the impact of current 2006 W.H.O. recommended control strategies. We then scored the number of years each of 10 typical villages would remain below 10% infection prevalence (a practicable level associated with minimal prevalence of disease). All strategies that included four annual treatments effectively reduced community prevalence to less than 10%, while programs having yearly gaps ('holidays') failed to reach this objective in half of the communities. Effective post-program suppression of infection prevalence persisted in half of the 10 villages for 7-10 years, whereas in five high-risk villages, program effects on prevalence lasted zero to four years only.At typical levels of treatment adherence (60 to 70%), current WHO recommendations will likely not achieve effective suppression of Schistosoma prevalence unless implemented for ≥6 years. Following more aggressive 4 year annual intervention, some communities may be able to continue without further intervention for 8-10 years, while in higher-risk communities, annual treatment may prove necessary until eco-social ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 11 e1903 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xiaoxia Wang David Gurarie Peter L Mungai Eric M Muchiri Uriel Kitron Charles H King Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Schistosomiasis remains a significant health burden in many areas of the world. Morbidity control, focused on limiting infection intensity through periodic delivery of anti-schistosomal medicines, is the thrust of current World Health Organization guidelines (2006) for reduction of Schistosoma-related disease. A new appreciation of the lifetime impact of repeated Schistosoma infection has directed attention toward strategies for greater suppression of parasite infection per se, with the goal of transmission interruption. Variations in drug schedules involving increased population coverage and/or treatment frequency are now undergoing field trials. However, their relative effectiveness in long-term infection suppression is presently unknown.Our study used available field data to calibrate advanced network models of village-level Schistosoma transmission to project outcomes of six different community- or school age-based programs, as compared to the impact of current 2006 W.H.O. recommended control strategies. We then scored the number of years each of 10 typical villages would remain below 10% infection prevalence (a practicable level associated with minimal prevalence of disease). All strategies that included four annual treatments effectively reduced community prevalence to less than 10%, while programs having yearly gaps ('holidays') failed to reach this objective in half of the communities. Effective post-program suppression of infection prevalence persisted in half of the 10 villages for 7-10 years, whereas in five high-risk villages, program effects on prevalence lasted zero to four years only.At typical levels of treatment adherence (60 to 70%), current WHO recommendations will likely not achieve effective suppression of Schistosoma prevalence unless implemented for ≥6 years. Following more aggressive 4 year annual intervention, some communities may be able to continue without further intervention for 8-10 years, while in higher-risk communities, annual treatment may prove necessary until eco-social ... |
format |
Article in Journal/Newspaper |
author |
Xiaoxia Wang David Gurarie Peter L Mungai Eric M Muchiri Uriel Kitron Charles H King |
author_facet |
Xiaoxia Wang David Gurarie Peter L Mungai Eric M Muchiri Uriel Kitron Charles H King |
author_sort |
Xiaoxia Wang |
title |
Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection. |
title_short |
Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection. |
title_full |
Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection. |
title_fullStr |
Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection. |
title_full_unstemmed |
Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection. |
title_sort |
projecting the long-term impact of school- or community-based mass-treatment interventions for control of schistosoma infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001903 https://doaj.org/article/1db03e0a493a4903a4cdf20fdb388dc8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1903 (2012) |
op_relation |
http://europepmc.org/articles/PMC3499404?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001903 https://doaj.org/article/1db03e0a493a4903a4cdf20fdb388dc8 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001903 |
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PLoS Neglected Tropical Diseases |
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6 |
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11 |
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e1903 |
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