Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain.
Background Imported schistosomiasis is an emerging issue in European countries as a result of growing global migration from schistosomiasis-endemic countries, mainly in sub-Saharan Africa. Undetected infection may lead to serious long-term complications with an associated high cost for public health...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0011221 https://doaj.org/article/1da83205b8b74d3aa8751f7b8b6ed85b |
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ftdoajarticles:oai:doaj.org/article:1da83205b8b74d3aa8751f7b8b6ed85b 2023-06-11T04:10:01+02:00 Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain. Sílvia Roure Francesc López Irene Oliva Olga Pérez-Quílez Oriol March Anna Chamorro Elena Abad Israel López Muñoz Amaia Castillo Laura Soldevila Lluís Valerio Manolo Lozano Helena Masnou Mario Oliveira Laura Cañas Mireia Gibrat Marta Chuecos Juan José Montero Karen Colmenares Gemma Falguera Josep Maria Bonet Mar Isnard Núria Prat Oriol Estrada Bonaventura Clotet Xavier Vallès 2023-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011221 https://doaj.org/article/1da83205b8b74d3aa8751f7b8b6ed85b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011221 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011221 https://doaj.org/article/1da83205b8b74d3aa8751f7b8b6ed85b PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011221 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011221 2023-05-07T00:31:57Z Background Imported schistosomiasis is an emerging issue in European countries as a result of growing global migration from schistosomiasis-endemic countries, mainly in sub-Saharan Africa. Undetected infection may lead to serious long-term complications with an associated high cost for public healthcare systems especially among long-term migrants. Objective To evaluate from a health economics perspective the introduction of schistosomiasis screening programs in non-endemic countries with high prevalence of long-term migrants. Methodology We calculated the costs associated with three approaches-presumptive treatment, test-and-treat and watchful waiting-under different scenarios of prevalence, treatment efficacy and the cost of care resulting from long-term morbidity. Costs were estimated for our study area, in which there are reported to reside 74,000 individuals who have been exposed to the infection. Additionally, we methodically reviewed the potential factors that could affect the cost/benefit ratio of a schistosomiasis screening program and need therefore to be ascertained. Results Assuming a 24% prevalence of schistosomiasis in the exposed population and 100% treatment efficacy, the estimated associated cost per infected person of a watchful waiting strategy would be €2,424, that of a presumptive treatment strategy would be €970 and that of a test-and-treat strategy would be €360. The difference in averted costs between test-and-treat and watchful waiting strategies ranges from nearly €60 million in scenarios of high prevalence and treatment efficacy, to a neutral costs ratio when these parameters are halved. However, there are important gaps in our understanding of issues such as the efficacy of treatment in infected long-term residents, the natural history of schistosomiasis in long-term migrants and the feasibility of screening programs. Conclusion Our results support the roll-out of a schistosomiasis screening program based on a test-and-treat strategy from a health economics perspective under the most ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 4 e0011221 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sílvia Roure Francesc López Irene Oliva Olga Pérez-Quílez Oriol March Anna Chamorro Elena Abad Israel López Muñoz Amaia Castillo Laura Soldevila Lluís Valerio Manolo Lozano Helena Masnou Mario Oliveira Laura Cañas Mireia Gibrat Marta Chuecos Juan José Montero Karen Colmenares Gemma Falguera Josep Maria Bonet Mar Isnard Núria Prat Oriol Estrada Bonaventura Clotet Xavier Vallès Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Imported schistosomiasis is an emerging issue in European countries as a result of growing global migration from schistosomiasis-endemic countries, mainly in sub-Saharan Africa. Undetected infection may lead to serious long-term complications with an associated high cost for public healthcare systems especially among long-term migrants. Objective To evaluate from a health economics perspective the introduction of schistosomiasis screening programs in non-endemic countries with high prevalence of long-term migrants. Methodology We calculated the costs associated with three approaches-presumptive treatment, test-and-treat and watchful waiting-under different scenarios of prevalence, treatment efficacy and the cost of care resulting from long-term morbidity. Costs were estimated for our study area, in which there are reported to reside 74,000 individuals who have been exposed to the infection. Additionally, we methodically reviewed the potential factors that could affect the cost/benefit ratio of a schistosomiasis screening program and need therefore to be ascertained. Results Assuming a 24% prevalence of schistosomiasis in the exposed population and 100% treatment efficacy, the estimated associated cost per infected person of a watchful waiting strategy would be €2,424, that of a presumptive treatment strategy would be €970 and that of a test-and-treat strategy would be €360. The difference in averted costs between test-and-treat and watchful waiting strategies ranges from nearly €60 million in scenarios of high prevalence and treatment efficacy, to a neutral costs ratio when these parameters are halved. However, there are important gaps in our understanding of issues such as the efficacy of treatment in infected long-term residents, the natural history of schistosomiasis in long-term migrants and the feasibility of screening programs. Conclusion Our results support the roll-out of a schistosomiasis screening program based on a test-and-treat strategy from a health economics perspective under the most ... |
format |
Article in Journal/Newspaper |
author |
Sílvia Roure Francesc López Irene Oliva Olga Pérez-Quílez Oriol March Anna Chamorro Elena Abad Israel López Muñoz Amaia Castillo Laura Soldevila Lluís Valerio Manolo Lozano Helena Masnou Mario Oliveira Laura Cañas Mireia Gibrat Marta Chuecos Juan José Montero Karen Colmenares Gemma Falguera Josep Maria Bonet Mar Isnard Núria Prat Oriol Estrada Bonaventura Clotet Xavier Vallès |
author_facet |
Sílvia Roure Francesc López Irene Oliva Olga Pérez-Quílez Oriol March Anna Chamorro Elena Abad Israel López Muñoz Amaia Castillo Laura Soldevila Lluís Valerio Manolo Lozano Helena Masnou Mario Oliveira Laura Cañas Mireia Gibrat Marta Chuecos Juan José Montero Karen Colmenares Gemma Falguera Josep Maria Bonet Mar Isnard Núria Prat Oriol Estrada Bonaventura Clotet Xavier Vallès |
author_sort |
Sílvia Roure |
title |
Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain. |
title_short |
Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain. |
title_full |
Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain. |
title_fullStr |
Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain. |
title_full_unstemmed |
Schistosomiasis screening in non-endemic countries from a cost perspective: Knowledge gaps and research priorities. The case of African long-term residents in a Metropolitan Area, Spain. |
title_sort |
schistosomiasis screening in non-endemic countries from a cost perspective: knowledge gaps and research priorities. the case of african long-term residents in a metropolitan area, spain. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011221 https://doaj.org/article/1da83205b8b74d3aa8751f7b8b6ed85b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011221 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011221 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011221 https://doaj.org/article/1da83205b8b74d3aa8751f7b8b6ed85b |
op_doi |
https://doi.org/10.1371/journal.pntd.0011221 |
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PLOS Neglected Tropical Diseases |
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17 |
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4 |
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e0011221 |
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