Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves
Aortic Valve Stenosis (AVS) has been explained as an atherosclerotic process of the valve as they often exhibit inflammatory changes with infiltration of macrophages, T lymphocytes and lipid infiltration. The present study investigated whether the bacteria Chlamydia pneumoniae (CP) and Mycoplasma pn...
Main Authors: | , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
2002
|
Subjects: | |
Online Access: | https://doaj.org/article/1cb7f67964ea466eb7eea40c4601a8d1 |
id |
ftdoajarticles:oai:doaj.org/article:1cb7f67964ea466eb7eea40c4601a8d1 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:1cb7f67964ea466eb7eea40c4601a8d1 2024-09-09T19:26:15+00:00 Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves Maria de Lourdes HIGUCHI Marilia Harumi HIGUCHI-DOS-SANTOS Humberto PIERRI Sueli PALOMINO Nadia Vieira SAMBIASE José Antonio Franchini RAMIRES Maurício WAJNGARTEN 2002-07-01T00:00:00Z https://doaj.org/article/1cb7f67964ea466eb7eea40c4601a8d1 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652002000400005&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/1cb7f67964ea466eb7eea40c4601a8d1 Revista do Instituto de Medicina Tropical de São Paulo, Vol 44, Iss 4, Pp 209-212 (2002) Mycoplasma pneumoniae Chlamydia pneumoniae Aortic Valve Calcification Atherosclerosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2002 ftdoajarticles 2024-08-05T17:49:30Z Aortic Valve Stenosis (AVS) has been explained as an atherosclerotic process of the valve as they often exhibit inflammatory changes with infiltration of macrophages, T lymphocytes and lipid infiltration. The present study investigated whether the bacteria Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP), detected previously in atherosclerotic plaques, are also present in AVS. Ten valves surgically removed from patients with AVS were analyzed by immunohistochemistry, in situ hybridization, and electron microscopy. The mean and standard deviation of the percentage areas occupied by CP antigens and MP - DNA were respectively 6.21 +/- 5.41 and 2.27 +/- 2.06 in calcified foci; 2.8 +/- 3.33 and 1.78+/- 3.63 in surrounding fibrotic areas, and 0.21 +/- 0.17 and 0.12 +/- 0.13 in less injured parts of the valve. There was higher amount of CP and MP in the calcified foci and in the surrounded fibrosis than in more preserved valvular regions. In conclusion, the fact that there were greater amounts of CP and MP in calcification foci of AVS favors the hypothesis that AS is not an inevitable degenerative process due to aging, but rather that it may be a response to the presence of these bacteria, similarly to the morphology detected in atherosclerosis damage. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Mycoplasma pneumoniae Chlamydia pneumoniae Aortic Valve Calcification Atherosclerosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Mycoplasma pneumoniae Chlamydia pneumoniae Aortic Valve Calcification Atherosclerosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Maria de Lourdes HIGUCHI Marilia Harumi HIGUCHI-DOS-SANTOS Humberto PIERRI Sueli PALOMINO Nadia Vieira SAMBIASE José Antonio Franchini RAMIRES Maurício WAJNGARTEN Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves |
topic_facet |
Mycoplasma pneumoniae Chlamydia pneumoniae Aortic Valve Calcification Atherosclerosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Aortic Valve Stenosis (AVS) has been explained as an atherosclerotic process of the valve as they often exhibit inflammatory changes with infiltration of macrophages, T lymphocytes and lipid infiltration. The present study investigated whether the bacteria Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP), detected previously in atherosclerotic plaques, are also present in AVS. Ten valves surgically removed from patients with AVS were analyzed by immunohistochemistry, in situ hybridization, and electron microscopy. The mean and standard deviation of the percentage areas occupied by CP antigens and MP - DNA were respectively 6.21 +/- 5.41 and 2.27 +/- 2.06 in calcified foci; 2.8 +/- 3.33 and 1.78+/- 3.63 in surrounding fibrotic areas, and 0.21 +/- 0.17 and 0.12 +/- 0.13 in less injured parts of the valve. There was higher amount of CP and MP in the calcified foci and in the surrounded fibrosis than in more preserved valvular regions. In conclusion, the fact that there were greater amounts of CP and MP in calcification foci of AVS favors the hypothesis that AS is not an inevitable degenerative process due to aging, but rather that it may be a response to the presence of these bacteria, similarly to the morphology detected in atherosclerosis damage. |
format |
Article in Journal/Newspaper |
author |
Maria de Lourdes HIGUCHI Marilia Harumi HIGUCHI-DOS-SANTOS Humberto PIERRI Sueli PALOMINO Nadia Vieira SAMBIASE José Antonio Franchini RAMIRES Maurício WAJNGARTEN |
author_facet |
Maria de Lourdes HIGUCHI Marilia Harumi HIGUCHI-DOS-SANTOS Humberto PIERRI Sueli PALOMINO Nadia Vieira SAMBIASE José Antonio Franchini RAMIRES Maurício WAJNGARTEN |
author_sort |
Maria de Lourdes HIGUCHI |
title |
Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves |
title_short |
Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves |
title_full |
Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves |
title_fullStr |
Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves |
title_full_unstemmed |
Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves |
title_sort |
mycoplasma pneumoniae and chlamydia pneumoniae in calcified nodules of aortic stenotic valves |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2002 |
url |
https://doaj.org/article/1cb7f67964ea466eb7eea40c4601a8d1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 44, Iss 4, Pp 209-212 (2002) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652002000400005&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/1cb7f67964ea466eb7eea40c4601a8d1 |
_version_ |
1809895910914654208 |