Is the thymus a target organ in infectious diseases?
The thymus is a central lymphoid organ, in wich T cell precursors differentiale and generate most of the so-called T cell reprtoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For ex...
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Instituto Oswaldo Cruz, Ministério da Saúde
1992
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ftdoajarticles:oai:doaj.org/article:1c8c8d2a40dd4140a0dd3d138fe49489 2023-05-15T15:08:14+02:00 Is the thymus a target organ in infectious diseases? Wilson Savino Maria do Carmo Leite de Moraes Suse Dayse Silva Barbosa Eliene de Carvalho da Fonseca Vinicius Cotta de Almeida Mireille Hontebeyrie-Joscowicz 1992-01-01T00:00:00Z https://doi.org/10.1590/S0074-02761992000900010 https://doaj.org/article/1c8c8d2a40dd4140a0dd3d138fe49489 EN eng Instituto Oswaldo Cruz, Ministério da Saúde http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900010 https://doaj.org/toc/0074-0276 https://doaj.org/toc/1678-8060 doi:10.1590/S0074-02761992000900010 0074-0276 1678-8060 https://doaj.org/article/1c8c8d2a40dd4140a0dd3d138fe49489 Memórias do Instituto Oswaldo Cruz., Vol 87, Pp 73-78 (1992) thymus thymic microenvironment thymocytes infectious diseases Chagas' disease schistosomiasis AIDS Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 article 1992 ftdoajarticles https://doi.org/10.1590/S0074-02761992000900010 2023-01-08T01:37:22Z The thymus is a central lymphoid organ, in wich T cell precursors differentiale and generate most of the so-called T cell reprtoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major and common feature observed in acute viral, bacterial and parasitic diseases, is a depletion of cortical thymocytes, mostly those bearing the CD4-CD8 double positive phenotype. This occurs simmultaneously to the relative enrichment in medullary CD4 or CD8 single positive cells, expressing high densities of the CD3 complex. Additionally we noticed a variety of changes in the thymic microenvironment (and particularly is epithelial component), comprising abnormal location of thymic epithelial cell subsets as well has a denser Ia-bearing cellular network. Moreover, the extracellular matrix network was altered with an intralobular increase of basement membrane proteins that positively correlated with the degree of thymocyte death. Lastly, anti-thymic cell antibodies were detected in both human and animal models of infectious diseases, and in some of them a phenomenon of molecular mimicry could be evidenced. Taken together, the data receiwed herein clearly show that the thymus should be regarded as a target in infectious diseases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Memórias do Instituto Oswaldo Cruz 87 suppl 5 73 78 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
thymus thymic microenvironment thymocytes infectious diseases Chagas' disease schistosomiasis AIDS Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
spellingShingle |
thymus thymic microenvironment thymocytes infectious diseases Chagas' disease schistosomiasis AIDS Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 Wilson Savino Maria do Carmo Leite de Moraes Suse Dayse Silva Barbosa Eliene de Carvalho da Fonseca Vinicius Cotta de Almeida Mireille Hontebeyrie-Joscowicz Is the thymus a target organ in infectious diseases? |
topic_facet |
thymus thymic microenvironment thymocytes infectious diseases Chagas' disease schistosomiasis AIDS Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
description |
The thymus is a central lymphoid organ, in wich T cell precursors differentiale and generate most of the so-called T cell reprtoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major and common feature observed in acute viral, bacterial and parasitic diseases, is a depletion of cortical thymocytes, mostly those bearing the CD4-CD8 double positive phenotype. This occurs simmultaneously to the relative enrichment in medullary CD4 or CD8 single positive cells, expressing high densities of the CD3 complex. Additionally we noticed a variety of changes in the thymic microenvironment (and particularly is epithelial component), comprising abnormal location of thymic epithelial cell subsets as well has a denser Ia-bearing cellular network. Moreover, the extracellular matrix network was altered with an intralobular increase of basement membrane proteins that positively correlated with the degree of thymocyte death. Lastly, anti-thymic cell antibodies were detected in both human and animal models of infectious diseases, and in some of them a phenomenon of molecular mimicry could be evidenced. Taken together, the data receiwed herein clearly show that the thymus should be regarded as a target in infectious diseases. |
format |
Article in Journal/Newspaper |
author |
Wilson Savino Maria do Carmo Leite de Moraes Suse Dayse Silva Barbosa Eliene de Carvalho da Fonseca Vinicius Cotta de Almeida Mireille Hontebeyrie-Joscowicz |
author_facet |
Wilson Savino Maria do Carmo Leite de Moraes Suse Dayse Silva Barbosa Eliene de Carvalho da Fonseca Vinicius Cotta de Almeida Mireille Hontebeyrie-Joscowicz |
author_sort |
Wilson Savino |
title |
Is the thymus a target organ in infectious diseases? |
title_short |
Is the thymus a target organ in infectious diseases? |
title_full |
Is the thymus a target organ in infectious diseases? |
title_fullStr |
Is the thymus a target organ in infectious diseases? |
title_full_unstemmed |
Is the thymus a target organ in infectious diseases? |
title_sort |
is the thymus a target organ in infectious diseases? |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
1992 |
url |
https://doi.org/10.1590/S0074-02761992000900010 https://doaj.org/article/1c8c8d2a40dd4140a0dd3d138fe49489 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Memórias do Instituto Oswaldo Cruz., Vol 87, Pp 73-78 (1992) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900010 https://doaj.org/toc/0074-0276 https://doaj.org/toc/1678-8060 doi:10.1590/S0074-02761992000900010 0074-0276 1678-8060 https://doaj.org/article/1c8c8d2a40dd4140a0dd3d138fe49489 |
op_doi |
https://doi.org/10.1590/S0074-02761992000900010 |
container_title |
Memórias do Instituto Oswaldo Cruz |
container_volume |
87 |
container_issue |
suppl 5 |
container_start_page |
73 |
op_container_end_page |
78 |
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1766339635383894016 |