Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis.
Background Ethiopia is one of the scarce African countries where Plasmodium vivax and P. falciparum co-exist. There has been no attempt to derive a robust prevalence estimate of P. vivax in the country although a clear understanding of the epidemiology of this parasite is essential for informed deci...
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ftdoajarticles:oai:doaj.org/article:1c6fe6029e7149109390cc61cf4d327b 2023-05-15T15:16:42+02:00 Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. Tsige Ketema Ketema Bacha Kefelegn Getahun Hernando A Del Portillo Quique Bassat 2021-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009781 https://doaj.org/article/1c6fe6029e7149109390cc61cf4d327b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009781 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009781 https://doaj.org/article/1c6fe6029e7149109390cc61cf4d327b PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009781 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009781 2022-12-31T04:33:59Z Background Ethiopia is one of the scarce African countries where Plasmodium vivax and P. falciparum co-exist. There has been no attempt to derive a robust prevalence estimate of P. vivax in the country although a clear understanding of the epidemiology of this parasite is essential for informed decisions. This systematic review and meta-analysis, therefore, is aimed to synthesize the available evidences on the distribution of P. vivax infection by different locations/regions, study years, eco-epidemiological zones, and study settings in Ethiopia. Methods This study was conducted in accordance with Preferred Reposting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. Studies conducted and published over the last two decades (2000 to 2020) that reported an estimate of P. vivax prevalence in Ethiopia were included. The Cochrane Q (χ2) and the I2 tests were used to assess heterogeneity, and the funnel plot and Egger's test were used to examine publication bias. A p-value of the χ2 test <0.05 and an I2 value >75% were considered presence of considerable heterogeneity. Random effect models were used to obtain pooled estimate of P. vivax infection prevalence. This study is registered with PROSPERO (International Prospective Register of Systematic Reviews): ID CRD42020201761. Results We screened 4,932 records and included 79 studies that enrolled 1,676,659 confirmed malaria cases, from which 548,214 (32.69%) were P. vivax infections and 1,116,581 (66.59%) were due to P. falciparum. The rest were due to mixed infections. The pooled estimate of P. vivax prevalence rate was 8.93% (95% CI: 7.98-9.88%) with significant heterogeneity (I2 = 100%, p<0.0001). Regional differences showed significant effects (p<0.0001, and I2 = 99.4%) on the pooled prevalence of P. vivax, while study years (before and after the scaling up of interventional activities) did not show significant differences (p = 0.9, I2 = 0%). Eco-epidemiological zones considered in the analysis did show a significant statistical effect ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) PLOS Neglected Tropical Diseases 15 9 e0009781 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tsige Ketema Ketema Bacha Kefelegn Getahun Hernando A Del Portillo Quique Bassat Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Ethiopia is one of the scarce African countries where Plasmodium vivax and P. falciparum co-exist. There has been no attempt to derive a robust prevalence estimate of P. vivax in the country although a clear understanding of the epidemiology of this parasite is essential for informed decisions. This systematic review and meta-analysis, therefore, is aimed to synthesize the available evidences on the distribution of P. vivax infection by different locations/regions, study years, eco-epidemiological zones, and study settings in Ethiopia. Methods This study was conducted in accordance with Preferred Reposting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. Studies conducted and published over the last two decades (2000 to 2020) that reported an estimate of P. vivax prevalence in Ethiopia were included. The Cochrane Q (χ2) and the I2 tests were used to assess heterogeneity, and the funnel plot and Egger's test were used to examine publication bias. A p-value of the χ2 test <0.05 and an I2 value >75% were considered presence of considerable heterogeneity. Random effect models were used to obtain pooled estimate of P. vivax infection prevalence. This study is registered with PROSPERO (International Prospective Register of Systematic Reviews): ID CRD42020201761. Results We screened 4,932 records and included 79 studies that enrolled 1,676,659 confirmed malaria cases, from which 548,214 (32.69%) were P. vivax infections and 1,116,581 (66.59%) were due to P. falciparum. The rest were due to mixed infections. The pooled estimate of P. vivax prevalence rate was 8.93% (95% CI: 7.98-9.88%) with significant heterogeneity (I2 = 100%, p<0.0001). Regional differences showed significant effects (p<0.0001, and I2 = 99.4%) on the pooled prevalence of P. vivax, while study years (before and after the scaling up of interventional activities) did not show significant differences (p = 0.9, I2 = 0%). Eco-epidemiological zones considered in the analysis did show a significant statistical effect ... |
format |
Article in Journal/Newspaper |
author |
Tsige Ketema Ketema Bacha Kefelegn Getahun Hernando A Del Portillo Quique Bassat |
author_facet |
Tsige Ketema Ketema Bacha Kefelegn Getahun Hernando A Del Portillo Quique Bassat |
author_sort |
Tsige Ketema |
title |
Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. |
title_short |
Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. |
title_full |
Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. |
title_fullStr |
Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. |
title_full_unstemmed |
Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis. |
title_sort |
plasmodium vivax epidemiology in ethiopia 2000-2020: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009781 https://doaj.org/article/1c6fe6029e7149109390cc61cf4d327b |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Arctic Prisma |
geographic_facet |
Arctic Prisma |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009781 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009781 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009781 https://doaj.org/article/1c6fe6029e7149109390cc61cf4d327b |
op_doi |
https://doi.org/10.1371/journal.pntd.0009781 |
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PLOS Neglected Tropical Diseases |
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9 |
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e0009781 |
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