Accelerated Evolution in Distinctive Species Reveals Candidate Elements for Clinically Relevant Traits, Including Mutation and Cancer Resistance

• Published in: Cell Reports
• Main Authors: Elliott Ferris, Lisa M. Abegglen, Joshua D. Schiffman, Christopher Gregg
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2018
• Subjects: Biology (General); QH301-705.5; Ferris; Orca
• Online Access: https://doi.org/10.1016/j.celrep.2018.02.008; https://doaj.org/article/1c6eb0e6f5a745c48768ca0a0d0959f6

Summary: The identity of most functional elements in the mammalian genome and the phenotypes they impact are unclear. Here, we perform a genome-wide comparative analysis of patterns of accelerated evolution in species with highly distinctive traits to discover candidate functional elements for clini...