Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis.
BACKGROUND:Global Program to Eliminate Lymphatic Filariasis (GPELF) launched by WHO aims to eliminate the disease by 2020. To achieve the goal annual mass drug administration (MDA) with diethylcarbamazine (DEC) plus albendazole (ABZ) has been introduced in all endemic countries. The current policy h...
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ftdoajarticles:oai:doaj.org/article:1c6af83130f34aba9befa91bfb3ab033 2023-05-15T15:11:49+02:00 Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis. Madhusmita Bal Prakash K Sahu Nityananda Mandal Ashok K Satapathy Manoranjan Ranjit Shatanu K Kar 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003955 https://doaj.org/article/1c6af83130f34aba9befa91bfb3ab033 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4520468?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003955 https://doaj.org/article/1c6af83130f34aba9befa91bfb3ab033 PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003955 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003955 2022-12-31T14:27:56Z BACKGROUND:Global Program to Eliminate Lymphatic Filariasis (GPELF) launched by WHO aims to eliminate the disease by 2020. To achieve the goal annual mass drug administration (MDA) with diethylcarbamazine (DEC) plus albendazole (ABZ) has been introduced in all endemic countries. The current policy however excludes pregnant mothers and children below two years of age from MDA. Since pregnancy and early childhood are critical periods in determining the disease outcome in older age, the present study was undertaken to find out the influence of maternal filarial infection at the time of pregnancy on the susceptibility outcome of children born in a community after implementation of MDA for the first time. METHODOLOGY AND PRINCIPAL FINDINGS:The participants in this cohort consists of pregnant mothers and their subsequently born children living in eight adjacent villages endemic for filarial infections, in Khurda District, Odisha, India, where MDA has reduced microfilariae (Mf) rate from 12% to 0.34%. Infection status of mother and their children were assessed by detection of Mf as well as circulating filarial antigen (CFA) assay. The present study reveals a high rate of acquiring filarial infection by the children born to infected mother than uninfected mothers even though Mf rate has come down to < 1% after implementation of ten rounds of MDA. SIGNIFICANCE:To attain the target of eliminating lymphatic filariasis the current MDA programme should give emphasis on covering the women of child bearing age. Our study recommends incorporating supervised MDA to Adolescent Reproductive and Sexual Health Programme (ARSH) to make the adolescent girls free from infection by the time of pregnancy so as to achieve the goal. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 7 e0003955 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Madhusmita Bal Prakash K Sahu Nityananda Mandal Ashok K Satapathy Manoranjan Ranjit Shatanu K Kar Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Global Program to Eliminate Lymphatic Filariasis (GPELF) launched by WHO aims to eliminate the disease by 2020. To achieve the goal annual mass drug administration (MDA) with diethylcarbamazine (DEC) plus albendazole (ABZ) has been introduced in all endemic countries. The current policy however excludes pregnant mothers and children below two years of age from MDA. Since pregnancy and early childhood are critical periods in determining the disease outcome in older age, the present study was undertaken to find out the influence of maternal filarial infection at the time of pregnancy on the susceptibility outcome of children born in a community after implementation of MDA for the first time. METHODOLOGY AND PRINCIPAL FINDINGS:The participants in this cohort consists of pregnant mothers and their subsequently born children living in eight adjacent villages endemic for filarial infections, in Khurda District, Odisha, India, where MDA has reduced microfilariae (Mf) rate from 12% to 0.34%. Infection status of mother and their children were assessed by detection of Mf as well as circulating filarial antigen (CFA) assay. The present study reveals a high rate of acquiring filarial infection by the children born to infected mother than uninfected mothers even though Mf rate has come down to < 1% after implementation of ten rounds of MDA. SIGNIFICANCE:To attain the target of eliminating lymphatic filariasis the current MDA programme should give emphasis on covering the women of child bearing age. Our study recommends incorporating supervised MDA to Adolescent Reproductive and Sexual Health Programme (ARSH) to make the adolescent girls free from infection by the time of pregnancy so as to achieve the goal. |
format |
Article in Journal/Newspaper |
author |
Madhusmita Bal Prakash K Sahu Nityananda Mandal Ashok K Satapathy Manoranjan Ranjit Shatanu K Kar |
author_facet |
Madhusmita Bal Prakash K Sahu Nityananda Mandal Ashok K Satapathy Manoranjan Ranjit Shatanu K Kar |
author_sort |
Madhusmita Bal |
title |
Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis. |
title_short |
Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis. |
title_full |
Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis. |
title_fullStr |
Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis. |
title_full_unstemmed |
Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis. |
title_sort |
maternal infection is a risk factor for early childhood infection in filariasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003955 https://doaj.org/article/1c6af83130f34aba9befa91bfb3ab033 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003955 (2015) |
op_relation |
http://europepmc.org/articles/PMC4520468?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003955 https://doaj.org/article/1c6af83130f34aba9befa91bfb3ab033 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003955 |
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PLOS Neglected Tropical Diseases |
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