Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid
Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid gen...
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ftdoajarticles:oai:doaj.org/article:1bf138e1f1d0474d9865708e0c6eb5ef 2024-09-15T17:48:17+00:00 Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh 2014-01-01T00:00:00Z https://doi.org/10.1155/2014/756418 https://doaj.org/article/1bf138e1f1d0474d9865708e0c6eb5ef EN eng Wiley http://dx.doi.org/10.1155/2014/756418 https://doaj.org/toc/2356-6140 https://doaj.org/toc/1537-744X 2356-6140 1537-744X doi:10.1155/2014/756418 https://doaj.org/article/1bf138e1f1d0474d9865708e0c6eb5ef The Scientific World Journal, Vol 2014 (2014) Technology T Medicine R Science Q article 2014 ftdoajarticles https://doi.org/10.1155/2014/756418 2024-08-05T17:48:38Z Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly for in situ oxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, the waste phenylacetic acid had the ability to be reused for epoxidation of the 1-nonene to 1-nonene oxide, giving an excellent yield of 90%. Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles The Scientific World Journal 2014 1 7 |
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topic |
Technology T Medicine R Science Q |
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Technology T Medicine R Science Q Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
topic_facet |
Technology T Medicine R Science Q |
description |
Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilised Candida antarctica lipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly for in situ oxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, the waste phenylacetic acid had the ability to be reused for epoxidation of the 1-nonene to 1-nonene oxide, giving an excellent yield of 90%. |
format |
Article in Journal/Newspaper |
author |
Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh |
author_facet |
Emilia Abdulmalek Mahashanon Arumugam Hanis Nabillah Mizan Mohd. Basyaruddin Abdul Rahman Mahiran Basri Abu Bakar Salleh |
author_sort |
Emilia Abdulmalek |
title |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_short |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_full |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_fullStr |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_full_unstemmed |
Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid |
title_sort |
chemoenzymatic epoxidation of alkenes and reusability study of the phenylacetic acid |
publisher |
Wiley |
publishDate |
2014 |
url |
https://doi.org/10.1155/2014/756418 https://doaj.org/article/1bf138e1f1d0474d9865708e0c6eb5ef |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
The Scientific World Journal, Vol 2014 (2014) |
op_relation |
http://dx.doi.org/10.1155/2014/756418 https://doaj.org/toc/2356-6140 https://doaj.org/toc/1537-744X 2356-6140 1537-744X doi:10.1155/2014/756418 https://doaj.org/article/1bf138e1f1d0474d9865708e0c6eb5ef |
op_doi |
https://doi.org/10.1155/2014/756418 |
container_title |
The Scientific World Journal |
container_volume |
2014 |
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1 |
op_container_end_page |
7 |
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1810289440229163008 |