Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Susana Restrepo, Angela M. Tabares, Angela Restrepo
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1992
• Subjects: Paracoccidioidomycosis; Experimental; Treatment; Triazole; Itraconazol; Schering 39304; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Alta; Arctic; Baja; Droga; Hongo
• Online Access: https://doi.org/10.1590/S0036-46651992000200014; https://doaj.org/article/1b2d1b4fb3d044fa914de7c087afa3d6

A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice sur...