Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice sur...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Language: | English |
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Universidade de São Paulo (USP)
1992
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Online Access: | https://doi.org/10.1590/S0036-46651992000200014 https://doaj.org/article/1b2d1b4fb3d044fa914de7c087afa3d6 |
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ftdoajarticles:oai:doaj.org/article:1b2d1b4fb3d044fa914de7c087afa3d6 2024-09-09T19:27:29+00:00 Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis Susana Restrepo Angela M. Tabares Angela Restrepo 1992-04-01T00:00:00Z https://doi.org/10.1590/S0036-46651992000200014 https://doaj.org/article/1b2d1b4fb3d044fa914de7c087afa3d6 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651992000200014 0036-4665 1678-9946 https://doaj.org/article/1b2d1b4fb3d044fa914de7c087afa3d6 Revista do Instituto de Medicina Tropical de São Paulo, Vol 34, Iss 2, Pp 171-176 (1992) Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1992 ftdoajarticles https://doi.org/10.1590/S0036-46651992000200014 2024-08-05T17:49:31Z A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis Un nuevo derivado triazólico Schering 39304 que tiene una vida promedio prolongada (60 horas), asi como otro triazol (itraconazole) de eficacia comprobada en la paracoccidioidomicosis, fueron ensayados en un modelo murino. Se encontró que solo sobrevivían el 15% de los animales infectados no tratados; del grupo tratado con Itrazonazol sobrevivieron el 53% de los que recibieron 20 mg/kg/dia y el 86% de aquellos con 50 mg/kg/dia. De los ratones que recibieron Sch 39304 sobrevivieron el 86% de los tratados con la dosis baja (5 mg/kg) y el 100% con la dosis mayor (20 mg/kg). Se encontraron diferencias estadísticamente significativas entre esta última droga y el itraconazol. Además, los cultivos de pulmón mostraron que solo Sch 39304 a la dosis alta, era capaz de erradicar el hongo de los tejidos. Estos resultados indican que tal triazol tendrá importancia en el tratamiento de la paracoccidioidomicosis humana Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Alta Arctic Baja Droga ENVELOPE(6.521,6.521,62.644,62.644) Hongo ENVELOPE(-67.867,-67.867,-68.883,-68.883) Revista do Instituto de Medicina Tropical de São Paulo 34 2 171 176 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Susana Restrepo Angela M. Tabares Angela Restrepo Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis |
topic_facet |
Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis Un nuevo derivado triazólico Schering 39304 que tiene una vida promedio prolongada (60 horas), asi como otro triazol (itraconazole) de eficacia comprobada en la paracoccidioidomicosis, fueron ensayados en un modelo murino. Se encontró que solo sobrevivían el 15% de los animales infectados no tratados; del grupo tratado con Itrazonazol sobrevivieron el 53% de los que recibieron 20 mg/kg/dia y el 86% de aquellos con 50 mg/kg/dia. De los ratones que recibieron Sch 39304 sobrevivieron el 86% de los tratados con la dosis baja (5 mg/kg) y el 100% con la dosis mayor (20 mg/kg). Se encontraron diferencias estadísticamente significativas entre esta última droga y el itraconazol. Además, los cultivos de pulmón mostraron que solo Sch 39304 a la dosis alta, era capaz de erradicar el hongo de los tejidos. Estos resultados indican que tal triazol tendrá importancia en el tratamiento de la paracoccidioidomicosis humana |
format |
Article in Journal/Newspaper |
author |
Susana Restrepo Angela M. Tabares Angela Restrepo |
author_facet |
Susana Restrepo Angela M. Tabares Angela Restrepo |
author_sort |
Susana Restrepo |
title |
Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis |
title_short |
Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis |
title_full |
Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis |
title_fullStr |
Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis |
title_full_unstemmed |
Activity of two different triazoles in a murine model of paracoccidioidomycosis Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis |
title_sort |
activity of two different triazoles in a murine model of paracoccidioidomycosis actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1992 |
url |
https://doi.org/10.1590/S0036-46651992000200014 https://doaj.org/article/1b2d1b4fb3d044fa914de7c087afa3d6 |
long_lat |
ENVELOPE(6.521,6.521,62.644,62.644) ENVELOPE(-67.867,-67.867,-68.883,-68.883) |
geographic |
Alta Arctic Baja Droga Hongo |
geographic_facet |
Alta Arctic Baja Droga Hongo |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 34, Iss 2, Pp 171-176 (1992) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651992000200014 0036-4665 1678-9946 https://doaj.org/article/1b2d1b4fb3d044fa914de7c087afa3d6 |
op_doi |
https://doi.org/10.1590/S0036-46651992000200014 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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34 |
container_issue |
2 |
container_start_page |
171 |
op_container_end_page |
176 |
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1809896907334483968 |