Congenital malaria with atypical presentation: A case report from low transmission area in India
Abstract Background Malaria during first few months of life may be due to transplacental transfer of parasitized maternal erythrocytes. Although IgG and IgM antimalarial antibodies can be detected in maternal blood, only IgG antibodies are present in the infant's blood. These antibodies can del...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2007
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-6-43 https://doaj.org/article/1b04239724a64e8bbab8eab63cdebc54 |
id |
ftdoajarticles:oai:doaj.org/article:1b04239724a64e8bbab8eab63cdebc54 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:1b04239724a64e8bbab8eab63cdebc54 2023-05-15T15:06:12+02:00 Congenital malaria with atypical presentation: A case report from low transmission area in India Biswas Sukla Mehta Sadhna Bhatia Sunita Valecha Neena Dash Aditya P 2007-04-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-43 https://doaj.org/article/1b04239724a64e8bbab8eab63cdebc54 EN eng BMC http://www.malariajournal.com/content/6/1/43 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-43 1475-2875 https://doaj.org/article/1b04239724a64e8bbab8eab63cdebc54 Malaria Journal, Vol 6, Iss 1, p 43 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-43 2023-01-08T01:32:55Z Abstract Background Malaria during first few months of life may be due to transplacental transfer of parasitized maternal erythrocytes. Although IgG and IgM antimalarial antibodies can be detected in maternal blood, only IgG antibodies are present in the infant's blood. These antibodies can delay and modify the onset of clinical manifestations. Case Presentation An infant is described who presented with irritability and feeding problems. Clinical examination and investigations revealed that the infant was afebrile, had jaundice, hepatosplenomegaly and haemolytic anaemia. Peripheral smear demonstrated Plasmodium vivax . While the mother had significant levels of immunoglobulin G (IgG), the infant was found negative for IgG and had low immunoglobulin M (IgM) levels. The mother had a history of febrile illness during pregnancy and her peripheral smear was also positive for P. vivax . Both were successfully treated with chloroquine in the dose of 25 mg/kg/day over three days. Conclusion The case emphasizes the importance of considering the diagnosis of malaria even in infants in low transmission area, who may not present with typical symptoms of malaria, such as fever, but have other clinical manifestations like jaundice and haemolytic anaemia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 6 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Biswas Sukla Mehta Sadhna Bhatia Sunita Valecha Neena Dash Aditya P Congenital malaria with atypical presentation: A case report from low transmission area in India |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria during first few months of life may be due to transplacental transfer of parasitized maternal erythrocytes. Although IgG and IgM antimalarial antibodies can be detected in maternal blood, only IgG antibodies are present in the infant's blood. These antibodies can delay and modify the onset of clinical manifestations. Case Presentation An infant is described who presented with irritability and feeding problems. Clinical examination and investigations revealed that the infant was afebrile, had jaundice, hepatosplenomegaly and haemolytic anaemia. Peripheral smear demonstrated Plasmodium vivax . While the mother had significant levels of immunoglobulin G (IgG), the infant was found negative for IgG and had low immunoglobulin M (IgM) levels. The mother had a history of febrile illness during pregnancy and her peripheral smear was also positive for P. vivax . Both were successfully treated with chloroquine in the dose of 25 mg/kg/day over three days. Conclusion The case emphasizes the importance of considering the diagnosis of malaria even in infants in low transmission area, who may not present with typical symptoms of malaria, such as fever, but have other clinical manifestations like jaundice and haemolytic anaemia. |
format |
Article in Journal/Newspaper |
author |
Biswas Sukla Mehta Sadhna Bhatia Sunita Valecha Neena Dash Aditya P |
author_facet |
Biswas Sukla Mehta Sadhna Bhatia Sunita Valecha Neena Dash Aditya P |
author_sort |
Biswas Sukla |
title |
Congenital malaria with atypical presentation: A case report from low transmission area in India |
title_short |
Congenital malaria with atypical presentation: A case report from low transmission area in India |
title_full |
Congenital malaria with atypical presentation: A case report from low transmission area in India |
title_fullStr |
Congenital malaria with atypical presentation: A case report from low transmission area in India |
title_full_unstemmed |
Congenital malaria with atypical presentation: A case report from low transmission area in India |
title_sort |
congenital malaria with atypical presentation: a case report from low transmission area in india |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-43 https://doaj.org/article/1b04239724a64e8bbab8eab63cdebc54 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 43 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/43 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-43 1475-2875 https://doaj.org/article/1b04239724a64e8bbab8eab63cdebc54 |
op_doi |
https://doi.org/10.1186/1475-2875-6-43 |
container_title |
Malaria Journal |
container_volume |
6 |
container_issue |
1 |
_version_ |
1766337849386336256 |