Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis
Epidemiological evidence from tuberculosis outbreaks revealed that some genotypes of M. tuberculosis are more transmissible and capable of causing disease than others. We analysed the plasma cytokine levels of pulmonary tuberculosis patients infected with different strains of M. tuberculosis to test...
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ftdoajarticles:oai:doaj.org/article:1af52e758ed84c5b97918424b5d9e34d 2024-09-09T19:26:48+00:00 Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis Adane Mihret Yonas Bekele Andre G. Loxton Abraham Aseffa Rawleigh Howe Gerhard Walzl 2012-01-01T00:00:00Z https://doi.org/10.1155/2012/518564 https://doaj.org/article/1af52e758ed84c5b97918424b5d9e34d EN eng Wiley http://dx.doi.org/10.1155/2012/518564 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/518564 https://doaj.org/article/1af52e758ed84c5b97918424b5d9e34d Journal of Tropical Medicine, Vol 2012 (2012) Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1155/2012/518564 2024-08-05T17:48:43Z Epidemiological evidence from tuberculosis outbreaks revealed that some genotypes of M. tuberculosis are more transmissible and capable of causing disease than others. We analysed the plasma cytokine levels of pulmonary tuberculosis patients infected with different strains of M. tuberculosis to test the hypothesis that immune responses would be linked to the bacterial genotype. Spoligotyping was carried out for genotyping, and we used Luminex technology to measure 17 cytokines (EGF, fractalkine, GM-CSF, IFN-γ, IL-1, IL-10, IL-12, IL-17, IL-4, IL-7, IL-9, IP-10, MCP-1, MCP-3, MIP-1β, TNF, and VEGF) from plasma samples of tuberculosis patients. The levels of IL-12 (p40), IL-4, IL-7, and MIP-1beta were higher in patients infected with lineage 3, however, it was only IL-4 which showed statistically significant difference (P<0.05) between lineage 3 and lineage 4. We further grouped the lineages into families (CAS, H and T families), and we found that the plasma level of IL-4 was significantly higher in patients infected with the CAS family (P<0.05) in comparison with T and H families. However, there was no difference between T and H families. Therefore, the higher level of IL-4 in lineage 3 families might indicate that possible differences in the response elicited from host depend on strain lineages in the studied population. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2012 1 6 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Adane Mihret Yonas Bekele Andre G. Loxton Abraham Aseffa Rawleigh Howe Gerhard Walzl Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Epidemiological evidence from tuberculosis outbreaks revealed that some genotypes of M. tuberculosis are more transmissible and capable of causing disease than others. We analysed the plasma cytokine levels of pulmonary tuberculosis patients infected with different strains of M. tuberculosis to test the hypothesis that immune responses would be linked to the bacterial genotype. Spoligotyping was carried out for genotyping, and we used Luminex technology to measure 17 cytokines (EGF, fractalkine, GM-CSF, IFN-γ, IL-1, IL-10, IL-12, IL-17, IL-4, IL-7, IL-9, IP-10, MCP-1, MCP-3, MIP-1β, TNF, and VEGF) from plasma samples of tuberculosis patients. The levels of IL-12 (p40), IL-4, IL-7, and MIP-1beta were higher in patients infected with lineage 3, however, it was only IL-4 which showed statistically significant difference (P<0.05) between lineage 3 and lineage 4. We further grouped the lineages into families (CAS, H and T families), and we found that the plasma level of IL-4 was significantly higher in patients infected with the CAS family (P<0.05) in comparison with T and H families. However, there was no difference between T and H families. Therefore, the higher level of IL-4 in lineage 3 families might indicate that possible differences in the response elicited from host depend on strain lineages in the studied population. |
format |
Article in Journal/Newspaper |
author |
Adane Mihret Yonas Bekele Andre G. Loxton Abraham Aseffa Rawleigh Howe Gerhard Walzl |
author_facet |
Adane Mihret Yonas Bekele Andre G. Loxton Abraham Aseffa Rawleigh Howe Gerhard Walzl |
author_sort |
Adane Mihret |
title |
Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis |
title_short |
Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis |
title_full |
Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis |
title_fullStr |
Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis |
title_full_unstemmed |
Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis |
title_sort |
plasma level of il-4 differs in patients infected with different modern lineages of m. tuberculosis |
publisher |
Wiley |
publishDate |
2012 |
url |
https://doi.org/10.1155/2012/518564 https://doaj.org/article/1af52e758ed84c5b97918424b5d9e34d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2012 (2012) |
op_relation |
http://dx.doi.org/10.1155/2012/518564 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/518564 https://doaj.org/article/1af52e758ed84c5b97918424b5d9e34d |
op_doi |
https://doi.org/10.1155/2012/518564 |
container_title |
Journal of Tropical Medicine |
container_volume |
2012 |
container_start_page |
1 |
op_container_end_page |
6 |
_version_ |
1809896356662214656 |