Production of septal fibrosis of the liver by means of foreign protein injections into rats
Similarities and differences in antigenic humoral responses and electrophoretic patterns between Capillaria hepatica and pig-serum were investigated as a contribution to the understanding of hepatic fibrosis induced by the parenteral administration of foreign proteins. Only two out of 10 rats receiv...
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Sociedade Brasileira de Medicina Tropical (SBMT)
2003
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ftdoajarticles:oai:doaj.org/article:1ad687079224449481b5ade8dc930453 2023-05-15T15:04:07+02:00 Production of septal fibrosis of the liver by means of foreign protein injections into rats Bruna Magalhães Gotardo Rodrigo Guimarães Andrade Ludmila Fernandes Oliveira Zilton A. Andrade 2003-10-01T00:00:00Z https://doaj.org/article/1ad687079224449481b5ade8dc930453 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000500006&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/1ad687079224449481b5ade8dc930453 Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 5, Pp 577-580 (2003) Capillaria hepatica Hepatic fibrosis Pig-serum model Arctic medicine. Tropical medicine RC955-962 article 2003 ftdoajarticles 2022-12-31T02:52:39Z Similarities and differences in antigenic humoral responses and electrophoretic patterns between Capillaria hepatica and pig-serum were investigated as a contribution to the understanding of hepatic fibrosis induced by the parenteral administration of foreign proteins. Only two out of 10 rats receiving repeated intraperitoneal injections of an extract of Capillaria hepatica-infected mouse liver presented septal hepatic fibrosis (20%). Under the same experimental conditions, 4 out of 9 rats (44.4%) developed septal fibrosis following whole pig-serum administration. Injections of normal mouse liver extracts did not result in hepatic fibrosis. Since a 100% septal fibrosis rate is observed in experimentally Capillaria hepatica-infected rats, it appeared that Capillaria hepatica products continuously released from inside the liver creates a much more effective fibrosis inducing mechanism than the parenteral administration of such factors. Thus, repeated peritoneal administration of a foreign protein to rats would not reveal the full fibrogenic potential it may have under natural conditions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Capillaria hepatica Hepatic fibrosis Pig-serum model Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Capillaria hepatica Hepatic fibrosis Pig-serum model Arctic medicine. Tropical medicine RC955-962 Bruna Magalhães Gotardo Rodrigo Guimarães Andrade Ludmila Fernandes Oliveira Zilton A. Andrade Production of septal fibrosis of the liver by means of foreign protein injections into rats |
topic_facet |
Capillaria hepatica Hepatic fibrosis Pig-serum model Arctic medicine. Tropical medicine RC955-962 |
description |
Similarities and differences in antigenic humoral responses and electrophoretic patterns between Capillaria hepatica and pig-serum were investigated as a contribution to the understanding of hepatic fibrosis induced by the parenteral administration of foreign proteins. Only two out of 10 rats receiving repeated intraperitoneal injections of an extract of Capillaria hepatica-infected mouse liver presented septal hepatic fibrosis (20%). Under the same experimental conditions, 4 out of 9 rats (44.4%) developed septal fibrosis following whole pig-serum administration. Injections of normal mouse liver extracts did not result in hepatic fibrosis. Since a 100% septal fibrosis rate is observed in experimentally Capillaria hepatica-infected rats, it appeared that Capillaria hepatica products continuously released from inside the liver creates a much more effective fibrosis inducing mechanism than the parenteral administration of such factors. Thus, repeated peritoneal administration of a foreign protein to rats would not reveal the full fibrogenic potential it may have under natural conditions. |
format |
Article in Journal/Newspaper |
author |
Bruna Magalhães Gotardo Rodrigo Guimarães Andrade Ludmila Fernandes Oliveira Zilton A. Andrade |
author_facet |
Bruna Magalhães Gotardo Rodrigo Guimarães Andrade Ludmila Fernandes Oliveira Zilton A. Andrade |
author_sort |
Bruna Magalhães Gotardo |
title |
Production of septal fibrosis of the liver by means of foreign protein injections into rats |
title_short |
Production of septal fibrosis of the liver by means of foreign protein injections into rats |
title_full |
Production of septal fibrosis of the liver by means of foreign protein injections into rats |
title_fullStr |
Production of septal fibrosis of the liver by means of foreign protein injections into rats |
title_full_unstemmed |
Production of septal fibrosis of the liver by means of foreign protein injections into rats |
title_sort |
production of septal fibrosis of the liver by means of foreign protein injections into rats |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2003 |
url |
https://doaj.org/article/1ad687079224449481b5ade8dc930453 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 5, Pp 577-580 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000500006&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/1ad687079224449481b5ade8dc930453 |
_version_ |
1766335930638008320 |