Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice
Objective. Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV) are several important flaviviruses, and infections caused by these flaviviruses remain worldwide health problems. Different flaviviruses exhibit different biological characteristics and pathogenicity. Metabolomi...
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ftdoajarticles:oai:doaj.org/article:1ab28a8baf5d446bb3f00d8c186b5636 2023-05-15T15:06:25+02:00 Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice Xiaoyan Zheng Ran Wang 2022-01-01T00:00:00Z https://doi.org/10.1155/2022/4663735 https://doaj.org/article/1ab28a8baf5d446bb3f00d8c186b5636 EN eng Hindawi Limited http://dx.doi.org/10.1155/2022/4663735 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2022/4663735 https://doaj.org/article/1ab28a8baf5d446bb3f00d8c186b5636 Journal of Tropical Medicine, Vol 2022 (2022) Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1155/2022/4663735 2022-12-31T02:45:08Z Objective. Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV) are several important flaviviruses, and infections caused by these flaviviruses remain worldwide health problems. Different flaviviruses exhibit different biological characteristics and pathogenicity. Metabolomics is an emerging research perspective to uncover and observe the pathogenesis of certain infections. Methods. To improve the understanding of the specific metabolic changes that occur during infection with different flaviviruses, considering the principle of noninvasive sampling, this article describes our comprehensive analysis of metabolites in urine samples from the three kinds of flavivirus-infected mice using a liquid chromatography tandem mass spectrometry method to better understand their infection mechanisms. Results. The urine of DENV-, JEV-, and ZIKV-infected mice had 68, 64, and 47 different differential metabolites, respectively, compared with the urine of control mice. Among the metabolic pathways designed by these metabolites, ABC transporters, arginine and proline metabolism, and regulation of lipolysis play an important role. Furthermore, we predicted and fitted potential relationships between metabolites and pathways. Conclusions. These virus-specific altered metabolites may be associated with their unique biological properties and pathogenicity. The metabolomic analysis of urine is very important for the analysis of flavivirus infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2022 1 12 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Xiaoyan Zheng Ran Wang Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Objective. Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV) are several important flaviviruses, and infections caused by these flaviviruses remain worldwide health problems. Different flaviviruses exhibit different biological characteristics and pathogenicity. Metabolomics is an emerging research perspective to uncover and observe the pathogenesis of certain infections. Methods. To improve the understanding of the specific metabolic changes that occur during infection with different flaviviruses, considering the principle of noninvasive sampling, this article describes our comprehensive analysis of metabolites in urine samples from the three kinds of flavivirus-infected mice using a liquid chromatography tandem mass spectrometry method to better understand their infection mechanisms. Results. The urine of DENV-, JEV-, and ZIKV-infected mice had 68, 64, and 47 different differential metabolites, respectively, compared with the urine of control mice. Among the metabolic pathways designed by these metabolites, ABC transporters, arginine and proline metabolism, and regulation of lipolysis play an important role. Furthermore, we predicted and fitted potential relationships between metabolites and pathways. Conclusions. These virus-specific altered metabolites may be associated with their unique biological properties and pathogenicity. The metabolomic analysis of urine is very important for the analysis of flavivirus infection. |
format |
Article in Journal/Newspaper |
author |
Xiaoyan Zheng Ran Wang |
author_facet |
Xiaoyan Zheng Ran Wang |
author_sort |
Xiaoyan Zheng |
title |
Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice |
title_short |
Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice |
title_full |
Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice |
title_fullStr |
Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice |
title_full_unstemmed |
Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice |
title_sort |
metabolomic analysis of key regulatory metabolites in the urine of flavivirus-infected mice |
publisher |
Hindawi Limited |
publishDate |
2022 |
url |
https://doi.org/10.1155/2022/4663735 https://doaj.org/article/1ab28a8baf5d446bb3f00d8c186b5636 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2022 (2022) |
op_relation |
http://dx.doi.org/10.1155/2022/4663735 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2022/4663735 https://doaj.org/article/1ab28a8baf5d446bb3f00d8c186b5636 |
op_doi |
https://doi.org/10.1155/2022/4663735 |
container_title |
Journal of Tropical Medicine |
container_volume |
2022 |
container_start_page |
1 |
op_container_end_page |
12 |
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1766338024737603584 |