Filarial worms reduce Plasmodium infectivity in mosquitoes.
Co-occurrence of malaria and filarial worm parasites has been reported, but little is known about the interaction between filarial worm and malaria parasites with the same Anopheles vector. Herein, we present data evaluating the interaction between Wuchereria bancrofti and Anopheles punctulatus in P...
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ftdoajarticles:oai:doaj.org/article:1a86f4a80e1242ccb0ad9d8536fbcc82 2023-05-15T15:15:18+02:00 Filarial worms reduce Plasmodium infectivity in mosquitoes. Matthew T Aliota Cheng-Chen Chen Henry Dagoro Jeremy F Fuchs Bruce M Christensen 2011-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000963 https://doaj.org/article/1a86f4a80e1242ccb0ad9d8536fbcc82 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3035669?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000963 https://doaj.org/article/1a86f4a80e1242ccb0ad9d8536fbcc82 PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e963 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000963 2022-12-31T09:49:49Z Co-occurrence of malaria and filarial worm parasites has been reported, but little is known about the interaction between filarial worm and malaria parasites with the same Anopheles vector. Herein, we present data evaluating the interaction between Wuchereria bancrofti and Anopheles punctulatus in Papua New Guinea (PNG). Our field studies in PNG demonstrated that An. punctulatus utilizes the melanization immune response as a natural mechanism of filarial worm resistance against invading W. bancrofti microfilariae. We then conducted laboratory studies utilizing the mosquitoes Armigeres subalbatus and Aedes aegypti and the parasites Brugia malayi, Brugia pahangi, Dirofilaria immitis, and Plasmodium gallinaceum to evaluate the hypothesis that immune activation and/or development by filarial worms negatively impact Plasmodium development in co-infected mosquitoes. Ar. subalbatus used in this study are natural vectors of P. gallinaceum and B. pahangi and they are naturally refractory to B. malayi (melanization-based refractoriness).Mosquitoes were dissected and Plasmodium development was analyzed six days after blood feeding on either P. gallinaceum alone or after taking a bloodmeal containing both P. gallinaceum and B. malayi or a bloodmeal containing both P. gallinaceum and B. pahangi. There was a significant reduction in the prevalence and mean intensity of Plasmodium infections in two species of mosquito that had dual infections as compared to those mosquitoes that were infected with Plasmodium alone, and was independent of whether the mosquito had a melanization immune response to the filarial worm or not. However, there was no reduction in Plasmodium development when filarial worms were present in the bloodmeal (D. immitis) but midgut penetration was absent, suggesting that factors associated with penetration of the midgut by filarial worms likely are responsible for the observed reduction in malaria parasite infections.These results could have an impact on vector infection and transmission dynamics in areas ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 2 e963 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Matthew T Aliota Cheng-Chen Chen Henry Dagoro Jeremy F Fuchs Bruce M Christensen Filarial worms reduce Plasmodium infectivity in mosquitoes. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Co-occurrence of malaria and filarial worm parasites has been reported, but little is known about the interaction between filarial worm and malaria parasites with the same Anopheles vector. Herein, we present data evaluating the interaction between Wuchereria bancrofti and Anopheles punctulatus in Papua New Guinea (PNG). Our field studies in PNG demonstrated that An. punctulatus utilizes the melanization immune response as a natural mechanism of filarial worm resistance against invading W. bancrofti microfilariae. We then conducted laboratory studies utilizing the mosquitoes Armigeres subalbatus and Aedes aegypti and the parasites Brugia malayi, Brugia pahangi, Dirofilaria immitis, and Plasmodium gallinaceum to evaluate the hypothesis that immune activation and/or development by filarial worms negatively impact Plasmodium development in co-infected mosquitoes. Ar. subalbatus used in this study are natural vectors of P. gallinaceum and B. pahangi and they are naturally refractory to B. malayi (melanization-based refractoriness).Mosquitoes were dissected and Plasmodium development was analyzed six days after blood feeding on either P. gallinaceum alone or after taking a bloodmeal containing both P. gallinaceum and B. malayi or a bloodmeal containing both P. gallinaceum and B. pahangi. There was a significant reduction in the prevalence and mean intensity of Plasmodium infections in two species of mosquito that had dual infections as compared to those mosquitoes that were infected with Plasmodium alone, and was independent of whether the mosquito had a melanization immune response to the filarial worm or not. However, there was no reduction in Plasmodium development when filarial worms were present in the bloodmeal (D. immitis) but midgut penetration was absent, suggesting that factors associated with penetration of the midgut by filarial worms likely are responsible for the observed reduction in malaria parasite infections.These results could have an impact on vector infection and transmission dynamics in areas ... |
format |
Article in Journal/Newspaper |
author |
Matthew T Aliota Cheng-Chen Chen Henry Dagoro Jeremy F Fuchs Bruce M Christensen |
author_facet |
Matthew T Aliota Cheng-Chen Chen Henry Dagoro Jeremy F Fuchs Bruce M Christensen |
author_sort |
Matthew T Aliota |
title |
Filarial worms reduce Plasmodium infectivity in mosquitoes. |
title_short |
Filarial worms reduce Plasmodium infectivity in mosquitoes. |
title_full |
Filarial worms reduce Plasmodium infectivity in mosquitoes. |
title_fullStr |
Filarial worms reduce Plasmodium infectivity in mosquitoes. |
title_full_unstemmed |
Filarial worms reduce Plasmodium infectivity in mosquitoes. |
title_sort |
filarial worms reduce plasmodium infectivity in mosquitoes. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0000963 https://doaj.org/article/1a86f4a80e1242ccb0ad9d8536fbcc82 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e963 (2011) |
op_relation |
http://europepmc.org/articles/PMC3035669?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000963 https://doaj.org/article/1a86f4a80e1242ccb0ad9d8536fbcc82 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000963 |
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PLoS Neglected Tropical Diseases |
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container_start_page |
e963 |
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