Involvement of the autonomic nervous system in Chagas heart disease
The autonomic nervous system and especially the intracardiac autonomic nervous system is involved in Chagas' disease. Ganglionitis and periganglionitis were noted in three groups ofpatients dying with Chagas'disease: 1) Those in heart failure; 2) Those dying a sudden, non violent death and...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1983
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ftdoajarticles:oai:doaj.org/article:1a3e3c30291b4e619ce995f04e5b9d94 2023-05-15T15:06:14+02:00 Involvement of the autonomic nervous system in Chagas heart disease Edison Reis Lopes Washington Luiz Tafuri 1983-12-01T00:00:00Z https://doi.org/10.1590/S0037-86821983000400007 https://doaj.org/article/1a3e3c30291b4e619ce995f04e5b9d94 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821983000400007&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821983000400007 https://doaj.org/article/1a3e3c30291b4e619ce995f04e5b9d94 Revista da Sociedade Brasileira de Medicina Tropical, Vol 16, Iss 4, Pp 206-212 (1983) Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Arctic medicine. Tropical medicine RC955-962 article 1983 ftdoajarticles https://doi.org/10.1590/S0037-86821983000400007 2022-12-31T02:58:05Z The autonomic nervous system and especially the intracardiac autonomic nervous system is involved in Chagas' disease. Ganglionitis and periganglionitis were noted in three groups ofpatients dying with Chagas'disease: 1) Those in heart failure; 2) Those dying a sudden, non violent death and; 3) Those dying as a consequence ofaccidents or homicide. Hearts in the threegroups also revealed myocarditis and scattered involvement of intramyocardial ganglion cells as well as lesions of myelinic and unmyelinic fibers ascribable to Chagas'disease. In mice with experimentally induced Chagas' disease weobserved more intensive neuronal lesions of the cardiac ganglia in the acute phase of infection. Perhaps neuronal loss has a role in the pathogenesis of Chagas cardiomyopathy. However based on our own experience and on other data from the literature we conclude that the loss of neurones is not the main factor responsible for the manifestations exhibited by chronic chagasic patients. On the other hand the neuronal lesions may have played a role in the sudden death ofone group of patients with Chagas'disease but is difficult to explain the group of patients who did not die sudderly but instead progressed to cardiac failure. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 16 4 206 212 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Arctic medicine. Tropical medicine RC955-962 Edison Reis Lopes Washington Luiz Tafuri Involvement of the autonomic nervous system in Chagas heart disease |
topic_facet |
Doença de Chagas Tripanossomose cruzi Cardiopatia chagásica Sistema nervoso autônomo Arctic medicine. Tropical medicine RC955-962 |
description |
The autonomic nervous system and especially the intracardiac autonomic nervous system is involved in Chagas' disease. Ganglionitis and periganglionitis were noted in three groups ofpatients dying with Chagas'disease: 1) Those in heart failure; 2) Those dying a sudden, non violent death and; 3) Those dying as a consequence ofaccidents or homicide. Hearts in the threegroups also revealed myocarditis and scattered involvement of intramyocardial ganglion cells as well as lesions of myelinic and unmyelinic fibers ascribable to Chagas'disease. In mice with experimentally induced Chagas' disease weobserved more intensive neuronal lesions of the cardiac ganglia in the acute phase of infection. Perhaps neuronal loss has a role in the pathogenesis of Chagas cardiomyopathy. However based on our own experience and on other data from the literature we conclude that the loss of neurones is not the main factor responsible for the manifestations exhibited by chronic chagasic patients. On the other hand the neuronal lesions may have played a role in the sudden death ofone group of patients with Chagas'disease but is difficult to explain the group of patients who did not die sudderly but instead progressed to cardiac failure. |
format |
Article in Journal/Newspaper |
author |
Edison Reis Lopes Washington Luiz Tafuri |
author_facet |
Edison Reis Lopes Washington Luiz Tafuri |
author_sort |
Edison Reis Lopes |
title |
Involvement of the autonomic nervous system in Chagas heart disease |
title_short |
Involvement of the autonomic nervous system in Chagas heart disease |
title_full |
Involvement of the autonomic nervous system in Chagas heart disease |
title_fullStr |
Involvement of the autonomic nervous system in Chagas heart disease |
title_full_unstemmed |
Involvement of the autonomic nervous system in Chagas heart disease |
title_sort |
involvement of the autonomic nervous system in chagas heart disease |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1983 |
url |
https://doi.org/10.1590/S0037-86821983000400007 https://doaj.org/article/1a3e3c30291b4e619ce995f04e5b9d94 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 16, Iss 4, Pp 206-212 (1983) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821983000400007&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821983000400007 https://doaj.org/article/1a3e3c30291b4e619ce995f04e5b9d94 |
op_doi |
https://doi.org/10.1590/S0037-86821983000400007 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
16 |
container_issue |
4 |
container_start_page |
206 |
op_container_end_page |
212 |
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