Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry
Bjorn Gudbjornsson,1,2 Arni Jon Geirsson,3,4 Niels Steen Krogh5 1Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland; 3Department of Rheumatology, University Hospital, Reykjavik, Iceland; 4Laeknasetrid - Medical C...
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ftdoajarticles:oai:doaj.org/article:1a2d9fd70fe74e35857fdaad12c0dba2 2023-05-15T16:45:39+02:00 Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry Gudbjornsson B Geirsson AJ Krogh NS 2018-05-01T00:00:00Z https://doaj.org/article/1a2d9fd70fe74e35857fdaad12c0dba2 EN eng Dove Medical Press https://www.dovepress.com/low-starting-dosage-of-infliximab-with-possible-escalating-dosage-in-p-peer-reviewed-article-PTT https://doaj.org/toc/2230-326X 2230-326X https://doaj.org/article/1a2d9fd70fe74e35857fdaad12c0dba2 Psoriasis: Targets and Therapy, Vol Volume 8, Pp 13-19 (2018) Psoriatic Arthritis outcome biological treatment routine care clinical nationwide registry Dermatology RL1-803 article 2018 ftdoajarticles 2022-12-31T04:22:03Z Bjorn Gudbjornsson,1,2 Arni Jon Geirsson,3,4 Niels Steen Krogh5 1Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland; 3Department of Rheumatology, University Hospital, Reykjavik, Iceland; 4Laeknasetrid - Medical Clinic, University of Iceland, Reykjavik, Iceland; 5Zitelab Aps, Copenhagen, Denmark Objective: To explore differences in response to a low dosage regimen of infliximab with an escalating dosage in comparison to a standard dosage of etanercept and adalimumab in patients with psoriatic arthritis (PsA). Methods: Biologically naïve PsA patients who were beginning anti-TNF-α therapy were selected from the ICEBIO registry. Demographics and clinical differences were compared in four treatment groups: infliximab <4 mg/kg; infliximab >4 mg/kg; etanercept or adalimumab at baseline and on follow-up (6 and 12 months, last visit). The Kruskal–Wallis rank sum test was used for comparison of the groups and the Wilcoxon test to compare the two infliximab dosage regimens. Results: One hundred and eighty-five patients (61% female) were identified; 84 patients received infliximab, 66 etanercept, and 35 adalimumab. A total of 19% of the patients treated with infliximab escalated their dosage ≥4 mg/kg. No significant differences were observed at baseline in respect to visual analog scale (VAS) pain, VAS fatigue, Health Assessment Questionnaire, C-reactive protein (CRP), numbers of swollen or tender joints, or Disease Activity Score (DAS) 28-CRP values. A similar treatment response was observed in all four treatment groups on follow-up. Conclusion: In respect to treatment effects, a low dosage of infliximab with possible escalating dosage is acceptable for the majority of PsA patients who are in need of biological treatment. Keywords: psoriatic arthritis, outcome, biological treatment, routine care, clinical nationwide registry Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles Steen ENVELOPE(7.780,7.780,62.571,62.571) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Psoriatic Arthritis outcome biological treatment routine care clinical nationwide registry Dermatology RL1-803 |
spellingShingle |
Psoriatic Arthritis outcome biological treatment routine care clinical nationwide registry Dermatology RL1-803 Gudbjornsson B Geirsson AJ Krogh NS Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry |
topic_facet |
Psoriatic Arthritis outcome biological treatment routine care clinical nationwide registry Dermatology RL1-803 |
description |
Bjorn Gudbjornsson,1,2 Arni Jon Geirsson,3,4 Niels Steen Krogh5 1Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland; 3Department of Rheumatology, University Hospital, Reykjavik, Iceland; 4Laeknasetrid - Medical Clinic, University of Iceland, Reykjavik, Iceland; 5Zitelab Aps, Copenhagen, Denmark Objective: To explore differences in response to a low dosage regimen of infliximab with an escalating dosage in comparison to a standard dosage of etanercept and adalimumab in patients with psoriatic arthritis (PsA). Methods: Biologically naïve PsA patients who were beginning anti-TNF-α therapy were selected from the ICEBIO registry. Demographics and clinical differences were compared in four treatment groups: infliximab <4 mg/kg; infliximab >4 mg/kg; etanercept or adalimumab at baseline and on follow-up (6 and 12 months, last visit). The Kruskal–Wallis rank sum test was used for comparison of the groups and the Wilcoxon test to compare the two infliximab dosage regimens. Results: One hundred and eighty-five patients (61% female) were identified; 84 patients received infliximab, 66 etanercept, and 35 adalimumab. A total of 19% of the patients treated with infliximab escalated their dosage ≥4 mg/kg. No significant differences were observed at baseline in respect to visual analog scale (VAS) pain, VAS fatigue, Health Assessment Questionnaire, C-reactive protein (CRP), numbers of swollen or tender joints, or Disease Activity Score (DAS) 28-CRP values. A similar treatment response was observed in all four treatment groups on follow-up. Conclusion: In respect to treatment effects, a low dosage of infliximab with possible escalating dosage is acceptable for the majority of PsA patients who are in need of biological treatment. Keywords: psoriatic arthritis, outcome, biological treatment, routine care, clinical nationwide registry |
format |
Article in Journal/Newspaper |
author |
Gudbjornsson B Geirsson AJ Krogh NS |
author_facet |
Gudbjornsson B Geirsson AJ Krogh NS |
author_sort |
Gudbjornsson B |
title |
Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry |
title_short |
Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry |
title_full |
Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry |
title_fullStr |
Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry |
title_full_unstemmed |
Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry |
title_sort |
low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide icelandic icebio registry |
publisher |
Dove Medical Press |
publishDate |
2018 |
url |
https://doaj.org/article/1a2d9fd70fe74e35857fdaad12c0dba2 |
long_lat |
ENVELOPE(7.780,7.780,62.571,62.571) |
geographic |
Steen |
geographic_facet |
Steen |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Psoriasis: Targets and Therapy, Vol Volume 8, Pp 13-19 (2018) |
op_relation |
https://www.dovepress.com/low-starting-dosage-of-infliximab-with-possible-escalating-dosage-in-p-peer-reviewed-article-PTT https://doaj.org/toc/2230-326X 2230-326X https://doaj.org/article/1a2d9fd70fe74e35857fdaad12c0dba2 |
_version_ |
1766035806658494464 |