Efficacy and Tolerability of Malartin and Sulphadoxine-Pyrimethamine Combination against Uncomplicated Falciparum Malaria in Dibanda, Southwest Cameroon

• Published in: Journal of Tropical Medicine
• Main Authors: Helen Kuokuo Kimbi, Mesame Ntoko, Nelson N. Ntonifor, Emmaculate Lum, Anna L. Njunda, Peter Nde Fon
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2012
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1155/2012/372518; https://doaj.org/article/1a184a9e076f43e6a3851003df84747e

Artemisinin derivatives are now the most potent and rapidly acting antimalarials. The aim of this study was to assess the in vivo efficacy and tolerability of a combination of Malartin (an artesunate) and sulphadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in Dibanda, Cameroon. A total of 197 subjects were recruited into the study and administered Malartin for 3 days and SP as a single dose on day 0. Only 174 of the subjects were successfully followed up on days 3, 7, and 14. The overall success rate of the drug combination was 92.53%. Parasite density decreased during the follow-up period in different age groups, sexes, and social classes. The prevalence of anaemia decreased from 22.99% at enrolment to 9.77% on day 14, and the difference was significant (P<0.05) on all days of followup. The drug combination did not give rise to any serious side effects.