Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente
Detection of anti-toxoplasma IgM antibodies has frequently been used as a serological marker for diagnosing recently acquired toxoplasmosis. However, the persistence of these antibodies in some patients has complicated the interpretation of serological results when toxoplasmosis is suspected. The pu...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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ftdoajarticles:oai:doaj.org/article:19dec27cf4bf40c5a30cc7de95df9286 2023-05-15T15:18:02+02:00 Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente Patrícia Regina Barboza Araújo Antonio Walter Ferreira 2008-04-01T00:00:00Z https://doi.org/10.1590/S0037-86822008000200002 https://doaj.org/article/19dec27cf4bf40c5a30cc7de95df9286 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822008000200002 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822008000200002 0037-8682 1678-9849 https://doaj.org/article/19dec27cf4bf40c5a30cc7de95df9286 Revista da Sociedade Brasileira de Medicina Tropical, Vol 41, Iss 2, Pp 142-147 (2008) Toxoplasmose Sorologia Avidez Antígenos de secreção-excreção Toxoplasmosis Serology Avidity Excreted/secreted antigens Arctic medicine. Tropical medicine RC955-962 article 2008 ftdoajarticles https://doi.org/10.1590/S0037-86822008000200002 2022-12-30T23:15:51Z Detection of anti-toxoplasma IgM antibodies has frequently been used as a serological marker for diagnosing recently acquired toxoplasmosis. However, the persistence of these antibodies in some patients has complicated the interpretation of serological results when toxoplasmosis is suspected. The purpose of the present study was to evaluate the avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii by means of immunoblot, to establish a profile for acute recent infection in a single serum sample and confirm the presence of residual IgM antibodies obtained in automated assays. When we evaluated the avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii by means of immunoblot, we observed phase-specific reactivity, i.e. cases of acute recent toxoplasmosis presented low avidity and cases of non-acute recent toxoplasmosis presented high avidity towards the 30kDa protein fraction, which probably corresponds to the SAG-1 surface antigen. Our results suggest that the avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii is an important immunological marker for distinguishing between recent infections and for determining the presence of residual IgM antibodies obtained from automated assays. A detecção de anticorpos IgM antitoxoplasma tem sido freqüentemente utilizada como marcador sorológico para o diagnóstico de toxoplasmose de aquisição recente. Entretanto, a persistência destes anticorpos em alguns pacientes tem complicado a interpretação dos resultados sorológicos quando a toxoplasmose é suspeitada. A proposta deste trabalho foi avaliar a avidez de anticorpos IgG contra antígenos de secreção e excreção de Toxoplasma gondii por immunoblot, para estabelecer um perfil de infecção recente aguda em uma única amostra de soro e confirmar a presença de anticorpos IgM residuais obtidos nos testes automatizados. Quando a avidez de anticorpos IgG contra antígenos de secreção e excreção Toxoplasma gondii, por immunoblot, foi avaliada, observou-se ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) Revista da Sociedade Brasileira de Medicina Tropical 41 2 142 147 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Toxoplasmose Sorologia Avidez Antígenos de secreção-excreção Toxoplasmosis Serology Avidity Excreted/secreted antigens Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Toxoplasmose Sorologia Avidez Antígenos de secreção-excreção Toxoplasmosis Serology Avidity Excreted/secreted antigens Arctic medicine. Tropical medicine RC955-962 Patrícia Regina Barboza Araújo Antonio Walter Ferreira Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente |
topic_facet |
Toxoplasmose Sorologia Avidez Antígenos de secreção-excreção Toxoplasmosis Serology Avidity Excreted/secreted antigens Arctic medicine. Tropical medicine RC955-962 |
description |
Detection of anti-toxoplasma IgM antibodies has frequently been used as a serological marker for diagnosing recently acquired toxoplasmosis. However, the persistence of these antibodies in some patients has complicated the interpretation of serological results when toxoplasmosis is suspected. The purpose of the present study was to evaluate the avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii by means of immunoblot, to establish a profile for acute recent infection in a single serum sample and confirm the presence of residual IgM antibodies obtained in automated assays. When we evaluated the avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii by means of immunoblot, we observed phase-specific reactivity, i.e. cases of acute recent toxoplasmosis presented low avidity and cases of non-acute recent toxoplasmosis presented high avidity towards the 30kDa protein fraction, which probably corresponds to the SAG-1 surface antigen. Our results suggest that the avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii is an important immunological marker for distinguishing between recent infections and for determining the presence of residual IgM antibodies obtained from automated assays. A detecção de anticorpos IgM antitoxoplasma tem sido freqüentemente utilizada como marcador sorológico para o diagnóstico de toxoplasmose de aquisição recente. Entretanto, a persistência destes anticorpos em alguns pacientes tem complicado a interpretação dos resultados sorológicos quando a toxoplasmose é suspeitada. A proposta deste trabalho foi avaliar a avidez de anticorpos IgG contra antígenos de secreção e excreção de Toxoplasma gondii por immunoblot, para estabelecer um perfil de infecção recente aguda em uma única amostra de soro e confirmar a presença de anticorpos IgM residuais obtidos nos testes automatizados. Quando a avidez de anticorpos IgG contra antígenos de secreção e excreção Toxoplasma gondii, por immunoblot, foi avaliada, observou-se ... |
format |
Article in Journal/Newspaper |
author |
Patrícia Regina Barboza Araújo Antonio Walter Ferreira |
author_facet |
Patrícia Regina Barboza Araújo Antonio Walter Ferreira |
author_sort |
Patrícia Regina Barboza Araújo |
title |
Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente |
title_short |
Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente |
title_full |
Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente |
title_fullStr |
Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente |
title_full_unstemmed |
Avidity of IgG antibodies against excreted/secreted antigens of Toxoplasma gondii: immunological marker for acute recent toxoplasmosis Avidez de anticorpos IgG anti-antígeno de secreção e excreção de Toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente |
title_sort |
avidity of igg antibodies against excreted/secreted antigens of toxoplasma gondii: immunological marker for acute recent toxoplasmosis avidez de anticorpos igg anti-antígeno de secreção e excreção de toxoplasma gondii: marcador imunológico de toxoplasmose aguda recente |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2008 |
url |
https://doi.org/10.1590/S0037-86822008000200002 https://doaj.org/article/19dec27cf4bf40c5a30cc7de95df9286 |
long_lat |
ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Arctic Aguda |
geographic_facet |
Arctic Aguda |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 41, Iss 2, Pp 142-147 (2008) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822008000200002 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822008000200002 0037-8682 1678-9849 https://doaj.org/article/19dec27cf4bf40c5a30cc7de95df9286 |
op_doi |
https://doi.org/10.1590/S0037-86822008000200002 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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