Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports
Objective: To explore the clinical features, diagnosis, etiology, treatment, and outcomes of COVID-19 related empyema. Methods: Using PRISMA statement, a systematic search of relevant case reports published between December 2019 and April 2023 was performed through seven databases. The collected dat...
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ftdoajarticles:oai:doaj.org/article:1996bbc9d1c941169ee4256429e154be 2023-11-12T04:13:46+01:00 Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports Yasser Ali Kamal Seham Abdelwakeel Abdel–Gaber 2023-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.383908 https://doaj.org/article/1996bbc9d1c941169ee4256429e154be EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=8;spage=337;epage=346;aulast=Kamal https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.383908 https://doaj.org/article/1996bbc9d1c941169ee4256429e154be Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 8, Pp 337-346 (2023) covid-19 sars-cov-2 empyema microbiology thoracic surgery Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.4103/1995-7645.383908 2023-10-29T00:38:43Z Objective: To explore the clinical features, diagnosis, etiology, treatment, and outcomes of COVID-19 related empyema. Methods: Using PRISMA statement, a systematic search of relevant case reports published between December 2019 and April 2023 was performed through seven databases. The collected data included demographics, clinical manifestations, diagnostic findings, treatment, and outcomes. Results: Thirty-six case reports were identified with 43 cases of empyema. The included cases had a median age of 55 years (range: 12-78 years) and 79.1% (34/43) were males. The majority of cases presented during hospitalization for management of acute COVID-19 infection (29/43, 67.4%) and Charlson comorbidity index <3 (40/43, 93.0%). Pseudomonas aeruginosa was the most commonly isolated microorganism from the pleural fluid (9/43, 20.9%) and 16.3% of the cases (7/43) had polymicrobial infections. Chest drainage was performed in all cases while surgery was indicated in 24 cases (55.8%). The most common complication of COVID-19-related empyema was broncho-pleural fistula (2/43, 4.7%). The mortality rate was 23.3% (10/43). Sepsis and/or multi-organ failure were the most commonly reported causes of death. On univariate analysis, no statistically significant risk factor for mortality was identified. Conclusions: COVID-19-associated empyema has a variety of predisposing factors, time of presentation, clinical features, and causative organisms. Invasive or minimally invasive surgical procedures are performed more frequently than isolated chest drainage. Empyema in COVID-19 patients worsens their prognosis and can lead to serious complications. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Asian Pacific Journal of Tropical Medicine 16 8 337 346 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
covid-19 sars-cov-2 empyema microbiology thoracic surgery Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
covid-19 sars-cov-2 empyema microbiology thoracic surgery Arctic medicine. Tropical medicine RC955-962 Yasser Ali Kamal Seham Abdelwakeel Abdel–Gaber Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports |
topic_facet |
covid-19 sars-cov-2 empyema microbiology thoracic surgery Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To explore the clinical features, diagnosis, etiology, treatment, and outcomes of COVID-19 related empyema. Methods: Using PRISMA statement, a systematic search of relevant case reports published between December 2019 and April 2023 was performed through seven databases. The collected data included demographics, clinical manifestations, diagnostic findings, treatment, and outcomes. Results: Thirty-six case reports were identified with 43 cases of empyema. The included cases had a median age of 55 years (range: 12-78 years) and 79.1% (34/43) were males. The majority of cases presented during hospitalization for management of acute COVID-19 infection (29/43, 67.4%) and Charlson comorbidity index <3 (40/43, 93.0%). Pseudomonas aeruginosa was the most commonly isolated microorganism from the pleural fluid (9/43, 20.9%) and 16.3% of the cases (7/43) had polymicrobial infections. Chest drainage was performed in all cases while surgery was indicated in 24 cases (55.8%). The most common complication of COVID-19-related empyema was broncho-pleural fistula (2/43, 4.7%). The mortality rate was 23.3% (10/43). Sepsis and/or multi-organ failure were the most commonly reported causes of death. On univariate analysis, no statistically significant risk factor for mortality was identified. Conclusions: COVID-19-associated empyema has a variety of predisposing factors, time of presentation, clinical features, and causative organisms. Invasive or minimally invasive surgical procedures are performed more frequently than isolated chest drainage. Empyema in COVID-19 patients worsens their prognosis and can lead to serious complications. |
format |
Article in Journal/Newspaper |
author |
Yasser Ali Kamal Seham Abdelwakeel Abdel–Gaber |
author_facet |
Yasser Ali Kamal Seham Abdelwakeel Abdel–Gaber |
author_sort |
Yasser Ali Kamal |
title |
Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports |
title_short |
Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports |
title_full |
Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports |
title_fullStr |
Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports |
title_full_unstemmed |
Clinical profile, etiology, management and outcome of empyema thoracis associated with COVID-19 infection: A systematic review of published case reports |
title_sort |
clinical profile, etiology, management and outcome of empyema thoracis associated with covid-19 infection: a systematic review of published case reports |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/1995-7645.383908 https://doaj.org/article/1996bbc9d1c941169ee4256429e154be |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 8, Pp 337-346 (2023) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=8;spage=337;epage=346;aulast=Kamal https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.383908 https://doaj.org/article/1996bbc9d1c941169ee4256429e154be |
op_doi |
https://doi.org/10.4103/1995-7645.383908 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
16 |
container_issue |
8 |
container_start_page |
337 |
op_container_end_page |
346 |
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1782331618904506368 |