The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study.
Background Protective effects of Bacillus Calmette-Guérin (BCG) vaccination and clofazimine and dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model for assessing the effects o...
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ftdoajarticles:oai:doaj.org/article:1973dd3437e44308a981ac2a1559e6ee 2023-05-15T15:10:26+02:00 The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. Selma Regina Penha Silva Cerqueira Patrícia Duarte Deps Débora Vilela Cunha Natanael Victor Furtunato Bezerra Daniel Holanda Barroso Ana Bárbara Sapienza Pinheiro Gecilmara Salviato Pillegi Taynah Alves Rocha Repsold Patrícia Shu Kurizky Simon M Collin Ciro Martins Gomes 2021-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009635 https://doaj.org/article/1973dd3437e44308a981ac2a1559e6ee EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009635 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009635 https://doaj.org/article/1973dd3437e44308a981ac2a1559e6ee PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009635 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009635 2023-02-05T01:26:50Z Background Protective effects of Bacillus Calmette-Guérin (BCG) vaccination and clofazimine and dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model for assessing the effects of these therapies on the occurrence and severity of coronavirus disease 2019 (COVID-19). We assessed the influence of leprosy-related variables in the occurrence and severity of COVID-19. Methodology/principal findings We performed a 14-month prospective real-world cohort study in which the main risk factor was 2 previous vaccinations with BCG and the main outcome was COVID-19 detection by reverse transcription polymerase chain reaction (RT-PCR). A Cox proportional hazards model was used. Among the 406 included patients, 113 were diagnosed with leprosy. During follow-up, 69 (16.99%) patients contracted COVID-19. Survival analysis showed that leprosy was associated with COVID-19 (p<0.001), but multivariate analysis showed that only COVID-19-positive household contacts (hazard ratio (HR) = 8.04; 95% CI = 4.93-13.11) and diabetes mellitus (HR = 2.06; 95% CI = 1.04-4.06) were significant risk factors for COVID-19. Conclusions/significance Leprosy patients are vulnerable to COVID-19 because they have more frequent contact with SARS-CoV-2-infected patients, possibly due to social and economic limitations. Our model showed that the use of corticosteroids, thalidomide, pentoxifylline, clofazimine, or dapsone or BCG vaccination did not affect the occurrence or severity of COVID-19. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Calmette ENVELOPE(-67.150,-67.150,-68.050,-68.050) PLOS Neglected Tropical Diseases 15 7 e0009635 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Selma Regina Penha Silva Cerqueira Patrícia Duarte Deps Débora Vilela Cunha Natanael Victor Furtunato Bezerra Daniel Holanda Barroso Ana Bárbara Sapienza Pinheiro Gecilmara Salviato Pillegi Taynah Alves Rocha Repsold Patrícia Shu Kurizky Simon M Collin Ciro Martins Gomes The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Protective effects of Bacillus Calmette-Guérin (BCG) vaccination and clofazimine and dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model for assessing the effects of these therapies on the occurrence and severity of coronavirus disease 2019 (COVID-19). We assessed the influence of leprosy-related variables in the occurrence and severity of COVID-19. Methodology/principal findings We performed a 14-month prospective real-world cohort study in which the main risk factor was 2 previous vaccinations with BCG and the main outcome was COVID-19 detection by reverse transcription polymerase chain reaction (RT-PCR). A Cox proportional hazards model was used. Among the 406 included patients, 113 were diagnosed with leprosy. During follow-up, 69 (16.99%) patients contracted COVID-19. Survival analysis showed that leprosy was associated with COVID-19 (p<0.001), but multivariate analysis showed that only COVID-19-positive household contacts (hazard ratio (HR) = 8.04; 95% CI = 4.93-13.11) and diabetes mellitus (HR = 2.06; 95% CI = 1.04-4.06) were significant risk factors for COVID-19. Conclusions/significance Leprosy patients are vulnerable to COVID-19 because they have more frequent contact with SARS-CoV-2-infected patients, possibly due to social and economic limitations. Our model showed that the use of corticosteroids, thalidomide, pentoxifylline, clofazimine, or dapsone or BCG vaccination did not affect the occurrence or severity of COVID-19. |
format |
Article in Journal/Newspaper |
author |
Selma Regina Penha Silva Cerqueira Patrícia Duarte Deps Débora Vilela Cunha Natanael Victor Furtunato Bezerra Daniel Holanda Barroso Ana Bárbara Sapienza Pinheiro Gecilmara Salviato Pillegi Taynah Alves Rocha Repsold Patrícia Shu Kurizky Simon M Collin Ciro Martins Gomes |
author_facet |
Selma Regina Penha Silva Cerqueira Patrícia Duarte Deps Débora Vilela Cunha Natanael Victor Furtunato Bezerra Daniel Holanda Barroso Ana Bárbara Sapienza Pinheiro Gecilmara Salviato Pillegi Taynah Alves Rocha Repsold Patrícia Shu Kurizky Simon M Collin Ciro Martins Gomes |
author_sort |
Selma Regina Penha Silva Cerqueira |
title |
The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. |
title_short |
The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. |
title_full |
The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. |
title_fullStr |
The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. |
title_full_unstemmed |
The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study. |
title_sort |
influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of covid-19: a prospective real-world cohort study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009635 https://doaj.org/article/1973dd3437e44308a981ac2a1559e6ee |
long_lat |
ENVELOPE(-67.150,-67.150,-68.050,-68.050) |
geographic |
Arctic Calmette |
geographic_facet |
Arctic Calmette |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009635 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009635 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009635 https://doaj.org/article/1973dd3437e44308a981ac2a1559e6ee |
op_doi |
https://doi.org/10.1371/journal.pntd.0009635 |
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PLOS Neglected Tropical Diseases |
container_volume |
15 |
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7 |
container_start_page |
e0009635 |
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1766341466510065664 |