A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment
Abstract Background Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains i...
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ftdoajarticles:oai:doaj.org/article:195c36e14ed84c93ad5338bdf60c41d2 2023-05-15T15:05:36+02:00 A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment Paul John Huggan Chin Hin Ng Jennifer Ho Raymond Tzer Pin Valentine Lin Jean-Marc Chavatte 2018-01-01T00:00:00Z https://doi.org/10.1186/s12936-018-2180-1 https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2180-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2180-1 1475-2875 https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2 Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018) Plasmodium falciparum Blackwater fever Persistent parasitaemia Artemether–lumefantrine PCR Haemoglobinuria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2180-1 2022-12-31T01:42:52Z Abstract Background Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains incompletely understood. Case presentation This report describes a case of classic blackwater fever in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether–lumefantrine combination therapy. Unusual persistence of submicroscopic Plasmodium falciparum parasitaemia was detected by PCR for 18 days after initiation of treatment. Conclusion To the authors’ knowledge this is the first reported occurrence of a case of blackwater fever associated with prolonged submicroscopic parasitaemia. This unusual case challenges the current knowledge of the pathogenesis of this condition and opens questions that may have important diagnostic and treatment implications. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Traveller ENVELOPE(-48.533,-48.533,61.133,61.133) Malaria Journal 17 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Plasmodium falciparum Blackwater fever Persistent parasitaemia Artemether–lumefantrine PCR Haemoglobinuria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Plasmodium falciparum Blackwater fever Persistent parasitaemia Artemether–lumefantrine PCR Haemoglobinuria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Paul John Huggan Chin Hin Ng Jennifer Ho Raymond Tzer Pin Valentine Lin Jean-Marc Chavatte A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment |
topic_facet |
Plasmodium falciparum Blackwater fever Persistent parasitaemia Artemether–lumefantrine PCR Haemoglobinuria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains incompletely understood. Case presentation This report describes a case of classic blackwater fever in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether–lumefantrine combination therapy. Unusual persistence of submicroscopic Plasmodium falciparum parasitaemia was detected by PCR for 18 days after initiation of treatment. Conclusion To the authors’ knowledge this is the first reported occurrence of a case of blackwater fever associated with prolonged submicroscopic parasitaemia. This unusual case challenges the current knowledge of the pathogenesis of this condition and opens questions that may have important diagnostic and treatment implications. |
format |
Article in Journal/Newspaper |
author |
Paul John Huggan Chin Hin Ng Jennifer Ho Raymond Tzer Pin Valentine Lin Jean-Marc Chavatte |
author_facet |
Paul John Huggan Chin Hin Ng Jennifer Ho Raymond Tzer Pin Valentine Lin Jean-Marc Chavatte |
author_sort |
Paul John Huggan |
title |
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment |
title_short |
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment |
title_full |
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment |
title_fullStr |
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment |
title_full_unstemmed |
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment |
title_sort |
case of blackwater fever with persistent plasmodium falciparum parasitaemia detected by pcr after artemether–lumefantrine treatment |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2180-1 https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2 |
long_lat |
ENVELOPE(-48.533,-48.533,61.133,61.133) |
geographic |
Arctic Traveller |
geographic_facet |
Arctic Traveller |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2180-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2180-1 1475-2875 https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2 |
op_doi |
https://doi.org/10.1186/s12936-018-2180-1 |
container_title |
Malaria Journal |
container_volume |
17 |
container_issue |
1 |
_version_ |
1766337270508421120 |