A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment

Abstract Background Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains i...

Full description

Bibliographic Details
Published in:Malaria Journal
Main Authors: Paul John Huggan, Chin Hin Ng, Jennifer Ho, Raymond Tzer Pin Valentine Lin, Jean-Marc Chavatte
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2018
Subjects:
PCR
Online Access:https://doi.org/10.1186/s12936-018-2180-1
https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2
id ftdoajarticles:oai:doaj.org/article:195c36e14ed84c93ad5338bdf60c41d2
record_format openpolar
spelling ftdoajarticles:oai:doaj.org/article:195c36e14ed84c93ad5338bdf60c41d2 2023-05-15T15:05:36+02:00 A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment Paul John Huggan Chin Hin Ng Jennifer Ho Raymond Tzer Pin Valentine Lin Jean-Marc Chavatte 2018-01-01T00:00:00Z https://doi.org/10.1186/s12936-018-2180-1 https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2180-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2180-1 1475-2875 https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2 Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018) Plasmodium falciparum Blackwater fever Persistent parasitaemia Artemether–lumefantrine PCR Haemoglobinuria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2180-1 2022-12-31T01:42:52Z Abstract Background Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains incompletely understood. Case presentation This report describes a case of classic blackwater fever in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether–lumefantrine combination therapy. Unusual persistence of submicroscopic Plasmodium falciparum parasitaemia was detected by PCR for 18 days after initiation of treatment. Conclusion To the authors’ knowledge this is the first reported occurrence of a case of blackwater fever associated with prolonged submicroscopic parasitaemia. This unusual case challenges the current knowledge of the pathogenesis of this condition and opens questions that may have important diagnostic and treatment implications. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Traveller ENVELOPE(-48.533,-48.533,61.133,61.133) Malaria Journal 17 1
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Plasmodium falciparum
Blackwater fever
Persistent parasitaemia
Artemether–lumefantrine
PCR
Haemoglobinuria
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
spellingShingle Plasmodium falciparum
Blackwater fever
Persistent parasitaemia
Artemether–lumefantrine
PCR
Haemoglobinuria
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Paul John Huggan
Chin Hin Ng
Jennifer Ho
Raymond Tzer Pin Valentine Lin
Jean-Marc Chavatte
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment
topic_facet Plasmodium falciparum
Blackwater fever
Persistent parasitaemia
Artemether–lumefantrine
PCR
Haemoglobinuria
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
description Abstract Background Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains incompletely understood. Case presentation This report describes a case of classic blackwater fever in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether–lumefantrine combination therapy. Unusual persistence of submicroscopic Plasmodium falciparum parasitaemia was detected by PCR for 18 days after initiation of treatment. Conclusion To the authors’ knowledge this is the first reported occurrence of a case of blackwater fever associated with prolonged submicroscopic parasitaemia. This unusual case challenges the current knowledge of the pathogenesis of this condition and opens questions that may have important diagnostic and treatment implications.
format Article in Journal/Newspaper
author Paul John Huggan
Chin Hin Ng
Jennifer Ho
Raymond Tzer Pin Valentine Lin
Jean-Marc Chavatte
author_facet Paul John Huggan
Chin Hin Ng
Jennifer Ho
Raymond Tzer Pin Valentine Lin
Jean-Marc Chavatte
author_sort Paul John Huggan
title A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment
title_short A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment
title_full A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment
title_fullStr A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment
title_full_unstemmed A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether–lumefantrine treatment
title_sort case of blackwater fever with persistent plasmodium falciparum parasitaemia detected by pcr after artemether–lumefantrine treatment
publisher BMC
publishDate 2018
url https://doi.org/10.1186/s12936-018-2180-1
https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2
long_lat ENVELOPE(-48.533,-48.533,61.133,61.133)
geographic Arctic
Traveller
geographic_facet Arctic
Traveller
genre Arctic
genre_facet Arctic
op_source Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018)
op_relation http://link.springer.com/article/10.1186/s12936-018-2180-1
https://doaj.org/toc/1475-2875
doi:10.1186/s12936-018-2180-1
1475-2875
https://doaj.org/article/195c36e14ed84c93ad5338bdf60c41d2
op_doi https://doi.org/10.1186/s12936-018-2180-1
container_title Malaria Journal
container_volume 17
container_issue 1
_version_ 1766337270508421120