Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis
Objective: To evaluate the outcomes of generic direct-acting antiviral treatments for chronic hepatitis C in Vietnam. Methods: The medical records of 522 patients (median 45 years; Female, 25.3%) with chronic hepatitis C treated at a tertiary hospital in northern Vietnam in 2016 were retrospectively...
Published in: | Asian Pacific Journal of Tropical Medicine |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2020
|
Subjects: | |
Online Access: | https://doi.org/10.4103/1995-7645.295358 https://doaj.org/article/1915176b3fc842228ee57fb8e0d0f937 |
id |
ftdoajarticles:oai:doaj.org/article:1915176b3fc842228ee57fb8e0d0f937 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:1915176b3fc842228ee57fb8e0d0f937 2023-05-15T15:14:49+02:00 Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis Huong TT Vu Azumi Ishizaki Quynh T Nguyen Huyen N Nguyen Hoi T Le Kinh V Nguyen Hiroshi Ichimura 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.295358 https://doaj.org/article/1915176b3fc842228ee57fb8e0d0f937 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=11;spage=487;epage=493;aulast=Vu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.295358 https://doaj.org/article/1915176b3fc842228ee57fb8e0d0f937 Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 11, Pp 487-493 (2020) vietnam chronic hepatitis c generic direct-acting antiviral improvement of liver stiffness Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.295358 2022-12-31T03:37:28Z Objective: To evaluate the outcomes of generic direct-acting antiviral treatments for chronic hepatitis C in Vietnam. Methods: The medical records of 522 patients (median 45 years; Female, 25.3%) with chronic hepatitis C treated at a tertiary hospital in northern Vietnam in 2016 were retrospectively reviewed. Results: Female patients were significantly older than male patients (median 52, IQR 41-59 vs. 43 years, IQR: 39-55; P<0.001). Among 522 patients, 49.4% were infected with hepatitis C virus (HCV) genotype 6, followed by 1a (19.0%), 1b (13.0%), and 3 (5.9%). Co-infection with hepatitis B virus or human immunodeficiency virus was noted in 5.8% and 3.1% of patients, respectively. Patients were treated with ledipasvir/sofosbuvir with or without ribavirin (70.9%), sofosbuvir/pegylated-interferon + ribavirin (13.2%), daclatasvir/ sofosbuvir with or without ribavirin (12.5%), or sofosbuvir/ribavirin (3.4%), and 96.4% (n=503) completed the direct-acting antiviral treatment. No patient discontinued treatment due to adverse event(s). A sustained virologic response 12 weeks after the end of the treatment (SVR12) was evaluated in 62.6% of patients. Overall sustained virologic response 12 weeks after the end of the treatment was 98.7% regardless of HCV genotypes or direct-acting antiviral regimens. The severity of liver stiffness was significantly decreased from 10.2 to 6.3 kilopascals measured by transient elastography by the treatment (P<0.001). Among patients who completed the direct-acting antiviral treatment, 17.7% returned for further follow-ups after SVR12. Conclusions: In Vietnam, the current generic direct-acting antiviral treatment for chronic hepatitis C was effective regardless of HCV genotypes and direct-acting antiviral regimens with the attenuation of liver stiffness. It is feasible to implement direct-acting antiviral treatment to cure chronic hepatitis C patients at any liver fibrosis stages in Vietnam. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 13 11 487 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
vietnam chronic hepatitis c generic direct-acting antiviral improvement of liver stiffness Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
vietnam chronic hepatitis c generic direct-acting antiviral improvement of liver stiffness Arctic medicine. Tropical medicine RC955-962 Huong TT Vu Azumi Ishizaki Quynh T Nguyen Huyen N Nguyen Hoi T Le Kinh V Nguyen Hiroshi Ichimura Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis |
topic_facet |
vietnam chronic hepatitis c generic direct-acting antiviral improvement of liver stiffness Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate the outcomes of generic direct-acting antiviral treatments for chronic hepatitis C in Vietnam. Methods: The medical records of 522 patients (median 45 years; Female, 25.3%) with chronic hepatitis C treated at a tertiary hospital in northern Vietnam in 2016 were retrospectively reviewed. Results: Female patients were significantly older than male patients (median 52, IQR 41-59 vs. 43 years, IQR: 39-55; P<0.001). Among 522 patients, 49.4% were infected with hepatitis C virus (HCV) genotype 6, followed by 1a (19.0%), 1b (13.0%), and 3 (5.9%). Co-infection with hepatitis B virus or human immunodeficiency virus was noted in 5.8% and 3.1% of patients, respectively. Patients were treated with ledipasvir/sofosbuvir with or without ribavirin (70.9%), sofosbuvir/pegylated-interferon + ribavirin (13.2%), daclatasvir/ sofosbuvir with or without ribavirin (12.5%), or sofosbuvir/ribavirin (3.4%), and 96.4% (n=503) completed the direct-acting antiviral treatment. No patient discontinued treatment due to adverse event(s). A sustained virologic response 12 weeks after the end of the treatment (SVR12) was evaluated in 62.6% of patients. Overall sustained virologic response 12 weeks after the end of the treatment was 98.7% regardless of HCV genotypes or direct-acting antiviral regimens. The severity of liver stiffness was significantly decreased from 10.2 to 6.3 kilopascals measured by transient elastography by the treatment (P<0.001). Among patients who completed the direct-acting antiviral treatment, 17.7% returned for further follow-ups after SVR12. Conclusions: In Vietnam, the current generic direct-acting antiviral treatment for chronic hepatitis C was effective regardless of HCV genotypes and direct-acting antiviral regimens with the attenuation of liver stiffness. It is feasible to implement direct-acting antiviral treatment to cure chronic hepatitis C patients at any liver fibrosis stages in Vietnam. |
format |
Article in Journal/Newspaper |
author |
Huong TT Vu Azumi Ishizaki Quynh T Nguyen Huyen N Nguyen Hoi T Le Kinh V Nguyen Hiroshi Ichimura |
author_facet |
Huong TT Vu Azumi Ishizaki Quynh T Nguyen Huyen N Nguyen Hoi T Le Kinh V Nguyen Hiroshi Ichimura |
author_sort |
Huong TT Vu |
title |
Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis |
title_short |
Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis |
title_full |
Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis |
title_fullStr |
Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis |
title_full_unstemmed |
Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis |
title_sort |
clinical outcomes of patients with chronic hepatitis c after generic direct-acting antiviral treatments in vietnam: a retrospective analysis |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.295358 https://doaj.org/article/1915176b3fc842228ee57fb8e0d0f937 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 11, Pp 487-493 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=11;spage=487;epage=493;aulast=Vu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.295358 https://doaj.org/article/1915176b3fc842228ee57fb8e0d0f937 |
op_doi |
https://doi.org/10.4103/1995-7645.295358 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
11 |
container_start_page |
487 |
_version_ |
1766345220932239360 |