Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates.
DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA methylation whereas invertebrate genomes are less methylated, predominantly within gene bodies. DNA methylation in invertebrates is associated with transcription level, alternative splicing and genome evolution, bu...
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ftdoajarticles:oai:doaj.org/article:1908ca175e7e449e840d847253da4f9a 2023-05-15T15:57:53+02:00 Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates. Guillaume eRiviere 2014-04-01T00:00:00Z https://doi.org/10.3389/fphys.2014.00129 https://doaj.org/article/1908ca175e7e449e840d847253da4f9a EN eng Frontiers Media S.A. http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00129/full https://doaj.org/toc/1664-042X 1664-042X doi:10.3389/fphys.2014.00129 https://doaj.org/article/1908ca175e7e449e840d847253da4f9a Frontiers in Physiology, Vol 5 (2014) DNA Methylation Invertebrates Transcription Genetic oyster Promoter Evolution Molecular Physiology QP1-981 article 2014 ftdoajarticles https://doi.org/10.3389/fphys.2014.00129 2022-12-30T23:01:47Z DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA methylation whereas invertebrate genomes are less methylated, predominantly within gene bodies. DNA methylation in invertebrates is associated with transcription level, alternative splicing and genome evolution, but functional outcomes of DNA methylation remain poorly described in lophotrochozoans. Recent genome-wide approaches improve understanding in distant taxa such as molluscs, where the phylogenetic position and life traits of Crassostrea gigas make this bivalve an ideal model to study the physiological and evolutionary implications of DNA methylation. We review the literature about DNA methylation in invertebrates and focus on DNA methylation features in the oyster. Indeed, though our MeDIP-seq results confirm predominant intragenic methylation, the profiles depend on the oyster’s developmental and reproductive stage. We discuss the perspective that oyster DNA methylation could be biased toward the 5’-end of some genes, depending on physiological status, suggesting important functional outcomes of putative promoter methylation from cell differentiation during early development to sustained adaptation of the species to the environment. Article in Journal/Newspaper Crassostrea gigas Directory of Open Access Journals: DOAJ Articles Frontiers in Physiology 5 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
DNA Methylation Invertebrates Transcription Genetic oyster Promoter Evolution Molecular Physiology QP1-981 |
spellingShingle |
DNA Methylation Invertebrates Transcription Genetic oyster Promoter Evolution Molecular Physiology QP1-981 Guillaume eRiviere Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates. |
topic_facet |
DNA Methylation Invertebrates Transcription Genetic oyster Promoter Evolution Molecular Physiology QP1-981 |
description |
DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA methylation whereas invertebrate genomes are less methylated, predominantly within gene bodies. DNA methylation in invertebrates is associated with transcription level, alternative splicing and genome evolution, but functional outcomes of DNA methylation remain poorly described in lophotrochozoans. Recent genome-wide approaches improve understanding in distant taxa such as molluscs, where the phylogenetic position and life traits of Crassostrea gigas make this bivalve an ideal model to study the physiological and evolutionary implications of DNA methylation. We review the literature about DNA methylation in invertebrates and focus on DNA methylation features in the oyster. Indeed, though our MeDIP-seq results confirm predominant intragenic methylation, the profiles depend on the oyster’s developmental and reproductive stage. We discuss the perspective that oyster DNA methylation could be biased toward the 5’-end of some genes, depending on physiological status, suggesting important functional outcomes of putative promoter methylation from cell differentiation during early development to sustained adaptation of the species to the environment. |
format |
Article in Journal/Newspaper |
author |
Guillaume eRiviere |
author_facet |
Guillaume eRiviere |
author_sort |
Guillaume eRiviere |
title |
Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates. |
title_short |
Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates. |
title_full |
Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates. |
title_fullStr |
Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates. |
title_full_unstemmed |
Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates. |
title_sort |
epigenetic features in the oyster crassostrea gigas suggestive of functionally relevant promoter dna methylation in invertebrates. |
publisher |
Frontiers Media S.A. |
publishDate |
2014 |
url |
https://doi.org/10.3389/fphys.2014.00129 https://doaj.org/article/1908ca175e7e449e840d847253da4f9a |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Frontiers in Physiology, Vol 5 (2014) |
op_relation |
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00129/full https://doaj.org/toc/1664-042X 1664-042X doi:10.3389/fphys.2014.00129 https://doaj.org/article/1908ca175e7e449e840d847253da4f9a |
op_doi |
https://doi.org/10.3389/fphys.2014.00129 |
container_title |
Frontiers in Physiology |
container_volume |
5 |
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1766393592993021952 |