Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness
Abstract Febrile symptoms in children are a leading cause of health-care seeking behaviour worldwide. The majority of febrile illnesses are uncomplicated and self-limited, without the need for referral or hospital admission. However, current diagnostic tools are unable to identify which febrile chil...
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ftdoajarticles:oai:doaj.org/article:18b2e60030704049b879d631883a8963 2023-05-15T15:10:31+02:00 Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness Chloe R. McDonald Andrea Weckman Melissa Richard-Greenblatt Aleksandra Leligdowicz Kevin C. Kain 2018-10-01T00:00:00Z https://doi.org/10.1186/s12936-018-2488-x https://doaj.org/article/18b2e60030704049b879d631883a8963 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2488-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2488-x 1475-2875 https://doaj.org/article/18b2e60030704049b879d631883a8963 Malaria Journal, Vol 17, Iss 1, Pp 1-7 (2018) Malaria Disease severity Severe malaria Innate immunity Inflammation Endothelial activation Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2488-x 2022-12-31T02:14:53Z Abstract Febrile symptoms in children are a leading cause of health-care seeking behaviour worldwide. The majority of febrile illnesses are uncomplicated and self-limited, without the need for referral or hospital admission. However, current diagnostic tools are unable to identify which febrile children have self-limited infection and which children are at risk of progressing to life-threatening infections, such as severe malaria. This paper describes the need for a simple community-based tool that can improve the early recognition and triage of febrile children, with either malarial or non-malarial illness, at risk of critical illness. The integration of a disease severity marker into existing malaria rapid diagnostic tests (RDT) could enable detection of children at risk of severe infection in the hospital and community, irrespective of aetiology. Incorporation of a disease severity marker could inform individualized management and early triage of children at risk of life-threatening infection. A child positive for both malaria and a disease severity marker could be prioritized for urgent referral/admission and parenteral therapy. A child positive for malaria and negative for a disease severity marker could be managed conservatively, as an out-patient, with oral anti-malarial therapy. An RDT with a disease severity marker could facilitate an integrated community-based approach to fever syndromes and improve early recognition, risk stratification, and prompt treatment of severe malaria and other life-threatening infections. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Disease severity Severe malaria Innate immunity Inflammation Endothelial activation Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Disease severity Severe malaria Innate immunity Inflammation Endothelial activation Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Chloe R. McDonald Andrea Weckman Melissa Richard-Greenblatt Aleksandra Leligdowicz Kevin C. Kain Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness |
topic_facet |
Malaria Disease severity Severe malaria Innate immunity Inflammation Endothelial activation Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Febrile symptoms in children are a leading cause of health-care seeking behaviour worldwide. The majority of febrile illnesses are uncomplicated and self-limited, without the need for referral or hospital admission. However, current diagnostic tools are unable to identify which febrile children have self-limited infection and which children are at risk of progressing to life-threatening infections, such as severe malaria. This paper describes the need for a simple community-based tool that can improve the early recognition and triage of febrile children, with either malarial or non-malarial illness, at risk of critical illness. The integration of a disease severity marker into existing malaria rapid diagnostic tests (RDT) could enable detection of children at risk of severe infection in the hospital and community, irrespective of aetiology. Incorporation of a disease severity marker could inform individualized management and early triage of children at risk of life-threatening infection. A child positive for both malaria and a disease severity marker could be prioritized for urgent referral/admission and parenteral therapy. A child positive for malaria and negative for a disease severity marker could be managed conservatively, as an out-patient, with oral anti-malarial therapy. An RDT with a disease severity marker could facilitate an integrated community-based approach to fever syndromes and improve early recognition, risk stratification, and prompt treatment of severe malaria and other life-threatening infections. |
format |
Article in Journal/Newspaper |
author |
Chloe R. McDonald Andrea Weckman Melissa Richard-Greenblatt Aleksandra Leligdowicz Kevin C. Kain |
author_facet |
Chloe R. McDonald Andrea Weckman Melissa Richard-Greenblatt Aleksandra Leligdowicz Kevin C. Kain |
author_sort |
Chloe R. McDonald |
title |
Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness |
title_short |
Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness |
title_full |
Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness |
title_fullStr |
Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness |
title_full_unstemmed |
Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness |
title_sort |
integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2488-x https://doaj.org/article/18b2e60030704049b879d631883a8963 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-7 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2488-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2488-x 1475-2875 https://doaj.org/article/18b2e60030704049b879d631883a8963 |
op_doi |
https://doi.org/10.1186/s12936-018-2488-x |
container_title |
Malaria Journal |
container_volume |
17 |
container_issue |
1 |
_version_ |
1766341541691916288 |