Diabetes and the occurrence of infection in primary care: a matched cohort study
Abstract Background People with diabetes may be at higher risk for acquiring infections through both glucose-dependent and biologic pathways independent of glycemic control. Our aim was to estimate the association between diabetes and infections occurring in primary care. Methods Using the Newfoundl...
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ftdoajarticles:oai:doaj.org/article:185273ba8f0b45d192b7878053c2dae0 2023-05-15T17:22:43+02:00 Diabetes and the occurrence of infection in primary care: a matched cohort study Waseem Abu-Ashour Laurie K Twells James E Valcour John-Michael Gamble 2018-02-01T00:00:00Z https://doi.org/10.1186/s12879-018-2975-2 https://doaj.org/article/185273ba8f0b45d192b7878053c2dae0 EN eng BMC http://link.springer.com/article/10.1186/s12879-018-2975-2 https://doaj.org/toc/1471-2334 doi:10.1186/s12879-018-2975-2 1471-2334 https://doaj.org/article/185273ba8f0b45d192b7878053c2dae0 BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-8 (2018) Diabetes Infection Primary care Matched cohort CPCSSN Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12879-018-2975-2 2022-12-31T09:52:00Z Abstract Background People with diabetes may be at higher risk for acquiring infections through both glucose-dependent and biologic pathways independent of glycemic control. Our aim was to estimate the association between diabetes and infections occurring in primary care. Methods Using the Newfoundland and Labrador Sentinel of the Canadian Primary Care Sentinel Surveillance Network, patients with diabetes ≥18 years between 1 January 2008 and 31 March 2013 were included with at least 1-year of follow-up. We randomly matched each patient with diabetes on the date of study entry with up to 8 controls without diabetes. Primary outcome was the occurrence of ≥1 primary care physician visits for any infectious disease. Secondary outcomes included primary visits for head & neck, respiratory, gastrointestinal, genitourinary, skin and soft tissue, musculoskeletal, and viral infections. Using multivariable conditional logistic regression analysis, we measured the independent association between diabetes and the occurrence of infections. Results We identified 1779 patients with diabetes who were matched to 11,066 patients without diabetes. Patients with diabetes were older, had a higher prevalence of comorbidities, and were more often referred to specialists. After adjusting for potential confounders, patients with diabetes had an increased risk of any infection compared to patients without diabetes (adjusted odds ratio = 1.21, 95% confidence interval 1.07–1.37). Skin and soft tissue infections had the strongest association, followed by genitourinary, gastrointestinal, and respiratory infections. Diabetes was not associated with head and neck, musculoskeletal, or viral infections. Conclusion Patients with diabetes appear to have an increased risk of certain infections compared to patients without diabetes. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Newfoundland BMC Infectious Diseases 18 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Diabetes Infection Primary care Matched cohort CPCSSN Infectious and parasitic diseases RC109-216 |
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Diabetes Infection Primary care Matched cohort CPCSSN Infectious and parasitic diseases RC109-216 Waseem Abu-Ashour Laurie K Twells James E Valcour John-Michael Gamble Diabetes and the occurrence of infection in primary care: a matched cohort study |
topic_facet |
Diabetes Infection Primary care Matched cohort CPCSSN Infectious and parasitic diseases RC109-216 |
description |
Abstract Background People with diabetes may be at higher risk for acquiring infections through both glucose-dependent and biologic pathways independent of glycemic control. Our aim was to estimate the association between diabetes and infections occurring in primary care. Methods Using the Newfoundland and Labrador Sentinel of the Canadian Primary Care Sentinel Surveillance Network, patients with diabetes ≥18 years between 1 January 2008 and 31 March 2013 were included with at least 1-year of follow-up. We randomly matched each patient with diabetes on the date of study entry with up to 8 controls without diabetes. Primary outcome was the occurrence of ≥1 primary care physician visits for any infectious disease. Secondary outcomes included primary visits for head & neck, respiratory, gastrointestinal, genitourinary, skin and soft tissue, musculoskeletal, and viral infections. Using multivariable conditional logistic regression analysis, we measured the independent association between diabetes and the occurrence of infections. Results We identified 1779 patients with diabetes who were matched to 11,066 patients without diabetes. Patients with diabetes were older, had a higher prevalence of comorbidities, and were more often referred to specialists. After adjusting for potential confounders, patients with diabetes had an increased risk of any infection compared to patients without diabetes (adjusted odds ratio = 1.21, 95% confidence interval 1.07–1.37). Skin and soft tissue infections had the strongest association, followed by genitourinary, gastrointestinal, and respiratory infections. Diabetes was not associated with head and neck, musculoskeletal, or viral infections. Conclusion Patients with diabetes appear to have an increased risk of certain infections compared to patients without diabetes. |
format |
Article in Journal/Newspaper |
author |
Waseem Abu-Ashour Laurie K Twells James E Valcour John-Michael Gamble |
author_facet |
Waseem Abu-Ashour Laurie K Twells James E Valcour John-Michael Gamble |
author_sort |
Waseem Abu-Ashour |
title |
Diabetes and the occurrence of infection in primary care: a matched cohort study |
title_short |
Diabetes and the occurrence of infection in primary care: a matched cohort study |
title_full |
Diabetes and the occurrence of infection in primary care: a matched cohort study |
title_fullStr |
Diabetes and the occurrence of infection in primary care: a matched cohort study |
title_full_unstemmed |
Diabetes and the occurrence of infection in primary care: a matched cohort study |
title_sort |
diabetes and the occurrence of infection in primary care: a matched cohort study |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12879-018-2975-2 https://doaj.org/article/185273ba8f0b45d192b7878053c2dae0 |
geographic |
Newfoundland |
geographic_facet |
Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-8 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12879-018-2975-2 https://doaj.org/toc/1471-2334 doi:10.1186/s12879-018-2975-2 1471-2334 https://doaj.org/article/185273ba8f0b45d192b7878053c2dae0 |
op_doi |
https://doi.org/10.1186/s12879-018-2975-2 |
container_title |
BMC Infectious Diseases |
container_volume |
18 |
container_issue |
1 |
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1766109546082729984 |