Isolation and structural elucidation of antifungal compounds from Curcuma amada
Objective: To isolate and identify the antifungal compounds from Curcuma amada. Methods: The antifungal activity was measured by the diameter of colonies grown on Petri dish, microscopic observation, and CLSI microdilution methods. The antifungal compounds were isolated through bioactivity guided pu...
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ftdoajarticles:oai:doaj.org/article:18493592952b46309d199777e468f0b3 2023-05-15T15:04:28+02:00 Isolation and structural elucidation of antifungal compounds from Curcuma amada Jesmin Akter Kensaku Takara Md. Zahorul Islam Md. Amzad Hossain Ayako Sano De-Xing Hou 2019-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.254938 https://doaj.org/article/18493592952b46309d199777e468f0b3 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=3;spage=123;epage=129;aulast=Akter https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.254938 https://doaj.org/article/18493592952b46309d199777e468f0b3 Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 3, Pp 123-129 (2019) curcuma amada fusarium solani sensu lato antifungal compounds zederone furanodienone nuclear magnetic resonance Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.4103/1995-7645.254938 2022-12-31T08:18:36Z Objective: To isolate and identify the antifungal compounds from Curcuma amada. Methods: The antifungal activity was measured by the diameter of colonies grown on Petri dish, microscopic observation, and CLSI microdilution methods. The antifungal compounds were isolated through bioactivity guided purification by using silica gel and high-performance liquid chromatography. Structural identification of the antifungal compounds was conducted using 1H NMR, 13C NMR, and liquid chromatography-tandem mass spectrometry. Results: The purified antifungal compounds were zederone and furanodienone. These two compounds showed dose-dependent antifungal activity against Fusarium solani sensu lato. The concentration required for 50% growth inhibition (IC50) of FSSL ranged from 115 to 129 μM and 82 to 91 μM for zederone and furanodienone, respectively. Conclusion: This study suggested that the isolated compounds from Curcuma amada could be promising natural antifungal agents to control the diseases caused by Fusarium solani sensu lato. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 12 3 123 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
curcuma amada fusarium solani sensu lato antifungal compounds zederone furanodienone nuclear magnetic resonance Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
curcuma amada fusarium solani sensu lato antifungal compounds zederone furanodienone nuclear magnetic resonance Arctic medicine. Tropical medicine RC955-962 Jesmin Akter Kensaku Takara Md. Zahorul Islam Md. Amzad Hossain Ayako Sano De-Xing Hou Isolation and structural elucidation of antifungal compounds from Curcuma amada |
topic_facet |
curcuma amada fusarium solani sensu lato antifungal compounds zederone furanodienone nuclear magnetic resonance Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To isolate and identify the antifungal compounds from Curcuma amada. Methods: The antifungal activity was measured by the diameter of colonies grown on Petri dish, microscopic observation, and CLSI microdilution methods. The antifungal compounds were isolated through bioactivity guided purification by using silica gel and high-performance liquid chromatography. Structural identification of the antifungal compounds was conducted using 1H NMR, 13C NMR, and liquid chromatography-tandem mass spectrometry. Results: The purified antifungal compounds were zederone and furanodienone. These two compounds showed dose-dependent antifungal activity against Fusarium solani sensu lato. The concentration required for 50% growth inhibition (IC50) of FSSL ranged from 115 to 129 μM and 82 to 91 μM for zederone and furanodienone, respectively. Conclusion: This study suggested that the isolated compounds from Curcuma amada could be promising natural antifungal agents to control the diseases caused by Fusarium solani sensu lato. |
format |
Article in Journal/Newspaper |
author |
Jesmin Akter Kensaku Takara Md. Zahorul Islam Md. Amzad Hossain Ayako Sano De-Xing Hou |
author_facet |
Jesmin Akter Kensaku Takara Md. Zahorul Islam Md. Amzad Hossain Ayako Sano De-Xing Hou |
author_sort |
Jesmin Akter |
title |
Isolation and structural elucidation of antifungal compounds from Curcuma amada |
title_short |
Isolation and structural elucidation of antifungal compounds from Curcuma amada |
title_full |
Isolation and structural elucidation of antifungal compounds from Curcuma amada |
title_fullStr |
Isolation and structural elucidation of antifungal compounds from Curcuma amada |
title_full_unstemmed |
Isolation and structural elucidation of antifungal compounds from Curcuma amada |
title_sort |
isolation and structural elucidation of antifungal compounds from curcuma amada |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/1995-7645.254938 https://doaj.org/article/18493592952b46309d199777e468f0b3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 3, Pp 123-129 (2019) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=3;spage=123;epage=129;aulast=Akter https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.254938 https://doaj.org/article/18493592952b46309d199777e468f0b3 |
op_doi |
https://doi.org/10.4103/1995-7645.254938 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
12 |
container_issue |
3 |
container_start_page |
123 |
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1766336232926740480 |