Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos)
Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for...
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ftdoajarticles:oai:doaj.org/article:182dd1f043f74887a7fa9dc4046d4d46 2023-05-15T18:41:56+02:00 Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) Amanda H. Boesen Alexandra Thiel Boris Fuchs Alina L. Evans Mads F. Bertelsen Ilia Rodushkin Jon M. Arnemo 2019-08-01T00:00:00Z https://doi.org/10.3389/fvets.2019.00285 https://doaj.org/article/182dd1f043f74887a7fa9dc4046d4d46 EN eng Frontiers Media S.A. https://www.frontiersin.org/article/10.3389/fvets.2019.00285/full https://doaj.org/toc/2297-1769 2297-1769 doi:10.3389/fvets.2019.00285 https://doaj.org/article/182dd1f043f74887a7fa9dc4046d4d46 Frontiers in Veterinary Science, Vol 6 (2019) blood lead lead exposure Ursus anodic stripping voltammetry Pb Veterinary medicine SF600-1100 article 2019 ftdoajarticles https://doi.org/10.3389/fvets.2019.00285 2022-12-31T12:53:47Z Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for use in some avian species and cattle, and are increasingly being used on wildlife to monitor lead exposure. The LeadCare® analyzers use a technique called anodic stripping voltammetry (ASV). Species-specific conversion equations have been proposed to approximate the levels found with gold standard measuring methods such as inductively coupled plasma mass spectrometry (ICP-MS) because the ASV method has been shown to underestimate BLL in some species. In this study we assessed the LeadCare® Plus (LCP) for use on Scandinavian brown bears (Ursus arctos). LCP measurements were correlated with ICP-MS with a Bland-Altman analyzed bias of 16.3–22.5%, showing a consistent overestimation of BLL analyzed with LCP. Based on this analysis we provide conversion equations for calculating ICP-MS BLL based on the LCP results in Scandinavian brown bears. Our study shows that the LeadCare® Plus can be used for monitoring of lead exposure by approximating gold standard levels using conversion equations. This enables comparison with other gold standard measured BLL within the observed range of this study (38.20–174.00 μg/L). Our study also found that Scandinavian brown bears are highly exposed to environmental lead. Article in Journal/Newspaper Ursus arctos Directory of Open Access Journals: DOAJ Articles Frontiers in Veterinary Science 6 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
blood lead lead exposure Ursus anodic stripping voltammetry Pb Veterinary medicine SF600-1100 |
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blood lead lead exposure Ursus anodic stripping voltammetry Pb Veterinary medicine SF600-1100 Amanda H. Boesen Alexandra Thiel Boris Fuchs Alina L. Evans Mads F. Bertelsen Ilia Rodushkin Jon M. Arnemo Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
topic_facet |
blood lead lead exposure Ursus anodic stripping voltammetry Pb Veterinary medicine SF600-1100 |
description |
Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for use in some avian species and cattle, and are increasingly being used on wildlife to monitor lead exposure. The LeadCare® analyzers use a technique called anodic stripping voltammetry (ASV). Species-specific conversion equations have been proposed to approximate the levels found with gold standard measuring methods such as inductively coupled plasma mass spectrometry (ICP-MS) because the ASV method has been shown to underestimate BLL in some species. In this study we assessed the LeadCare® Plus (LCP) for use on Scandinavian brown bears (Ursus arctos). LCP measurements were correlated with ICP-MS with a Bland-Altman analyzed bias of 16.3–22.5%, showing a consistent overestimation of BLL analyzed with LCP. Based on this analysis we provide conversion equations for calculating ICP-MS BLL based on the LCP results in Scandinavian brown bears. Our study shows that the LeadCare® Plus can be used for monitoring of lead exposure by approximating gold standard levels using conversion equations. This enables comparison with other gold standard measured BLL within the observed range of this study (38.20–174.00 μg/L). Our study also found that Scandinavian brown bears are highly exposed to environmental lead. |
format |
Article in Journal/Newspaper |
author |
Amanda H. Boesen Alexandra Thiel Boris Fuchs Alina L. Evans Mads F. Bertelsen Ilia Rodushkin Jon M. Arnemo |
author_facet |
Amanda H. Boesen Alexandra Thiel Boris Fuchs Alina L. Evans Mads F. Bertelsen Ilia Rodushkin Jon M. Arnemo |
author_sort |
Amanda H. Boesen |
title |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_short |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_full |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_fullStr |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_full_unstemmed |
Assessment of the LeadCare® Plus for Use on Scandinavian Brown Bears (Ursus arctos) |
title_sort |
assessment of the leadcare® plus for use on scandinavian brown bears (ursus arctos) |
publisher |
Frontiers Media S.A. |
publishDate |
2019 |
url |
https://doi.org/10.3389/fvets.2019.00285 https://doaj.org/article/182dd1f043f74887a7fa9dc4046d4d46 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Frontiers in Veterinary Science, Vol 6 (2019) |
op_relation |
https://www.frontiersin.org/article/10.3389/fvets.2019.00285/full https://doaj.org/toc/2297-1769 2297-1769 doi:10.3389/fvets.2019.00285 https://doaj.org/article/182dd1f043f74887a7fa9dc4046d4d46 |
op_doi |
https://doi.org/10.3389/fvets.2019.00285 |
container_title |
Frontiers in Veterinary Science |
container_volume |
6 |
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1766231512287543296 |