Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients
Abstract INTRODUCTION: Artemisinin-based combination therapy (ACT), such as artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine (DP), and artemether-lumefantrine (AL), is the first-line treatment for malaria in many malaria-endemic areas. However, we lack a detailed evaluation of the cardio...
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ftdoajarticles:oai:doaj.org/article:18044fc4f2fc4eb8a6fcb7a6387b2acf 2023-05-15T15:10:15+02:00 Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients Wanting Wu Chenguang Lu Yuan Liang Hongying Zhang Changsheng Deng Qi Wang Qin Xu Bo Tan Chongjun Zhou Jianping Song 2021-02-01T00:00:00Z https://doi.org/10.1590/0037-8682-0536-2020 https://doaj.org/article/18044fc4f2fc4eb8a6fcb7a6387b2acf EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100309&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0536-2020 https://doaj.org/article/18044fc4f2fc4eb8a6fcb7a6387b2acf Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2021) QT prolongation ACT Antimalarial ECG Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1590/0037-8682-0536-2020 2022-12-31T03:21:22Z Abstract INTRODUCTION: Artemisinin-based combination therapy (ACT), such as artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine (DP), and artemether-lumefantrine (AL), is the first-line treatment for malaria in many malaria-endemic areas. However, we lack a detailed evaluation of the cardiotoxicity of these ACTs. This study aimed to analyze the electrocardiographic effects of these three ACTs in malaria patients. METHODS: We analyzed the clinical data of 89 hospitalized patients with falciparum malaria who had received oral doses of three different ACTs. According to the ACTs administered, these patients were divided into three treatment groups: 27 treated with AP (Artequick), 31 with DP (Artekin), and 31 with AL (Coartem). Electrocardiograms and other indicators were recorded before and after the treatment. The QT interval was calculated using Fridericia’s formula (QTcF) and Bazett’s formula (QTcB). RESULTS: Both QTcF and QTcB interval prolongation occurred in all three groups. The incidence of such prolongation between the three groups was not significantly different. The incidence of both moderate and severe prolongation was not significantly different between the three groups. The ΔQTcF and ΔQTcB of the three groups were not significantly different. The intra-group comparison showed significant prolongation of QTcF after AL treatment. CONCLUSIONS: Clinically recommended doses of DP, AL, and AP may cause QT prolongation in some malaria patients but do not cause torsades de pointes ventricular tachycardia or other arrhythmias. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 54 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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QT prolongation ACT Antimalarial ECG Arctic medicine. Tropical medicine RC955-962 |
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QT prolongation ACT Antimalarial ECG Arctic medicine. Tropical medicine RC955-962 Wanting Wu Chenguang Lu Yuan Liang Hongying Zhang Changsheng Deng Qi Wang Qin Xu Bo Tan Chongjun Zhou Jianping Song Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients |
topic_facet |
QT prolongation ACT Antimalarial ECG Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Artemisinin-based combination therapy (ACT), such as artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine (DP), and artemether-lumefantrine (AL), is the first-line treatment for malaria in many malaria-endemic areas. However, we lack a detailed evaluation of the cardiotoxicity of these ACTs. This study aimed to analyze the electrocardiographic effects of these three ACTs in malaria patients. METHODS: We analyzed the clinical data of 89 hospitalized patients with falciparum malaria who had received oral doses of three different ACTs. According to the ACTs administered, these patients were divided into three treatment groups: 27 treated with AP (Artequick), 31 with DP (Artekin), and 31 with AL (Coartem). Electrocardiograms and other indicators were recorded before and after the treatment. The QT interval was calculated using Fridericia’s formula (QTcF) and Bazett’s formula (QTcB). RESULTS: Both QTcF and QTcB interval prolongation occurred in all three groups. The incidence of such prolongation between the three groups was not significantly different. The incidence of both moderate and severe prolongation was not significantly different between the three groups. The ΔQTcF and ΔQTcB of the three groups were not significantly different. The intra-group comparison showed significant prolongation of QTcF after AL treatment. CONCLUSIONS: Clinically recommended doses of DP, AL, and AP may cause QT prolongation in some malaria patients but do not cause torsades de pointes ventricular tachycardia or other arrhythmias. |
format |
Article in Journal/Newspaper |
author |
Wanting Wu Chenguang Lu Yuan Liang Hongying Zhang Changsheng Deng Qi Wang Qin Xu Bo Tan Chongjun Zhou Jianping Song |
author_facet |
Wanting Wu Chenguang Lu Yuan Liang Hongying Zhang Changsheng Deng Qi Wang Qin Xu Bo Tan Chongjun Zhou Jianping Song |
author_sort |
Wanting Wu |
title |
Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients |
title_short |
Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients |
title_full |
Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients |
title_fullStr |
Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients |
title_full_unstemmed |
Electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients |
title_sort |
electrocardiographic effect of artemisinin-piperaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine treatment in falciparum malaria patients |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2021 |
url |
https://doi.org/10.1590/0037-8682-0536-2020 https://doaj.org/article/18044fc4f2fc4eb8a6fcb7a6387b2acf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100309&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0536-2020 https://doaj.org/article/18044fc4f2fc4eb8a6fcb7a6387b2acf |
op_doi |
https://doi.org/10.1590/0037-8682-0536-2020 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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54 |
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